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Article: In vivo evaluation of retinal and callosal projections in early postnatal development and plasticity using manganese-enhanced mri and diffusion tensor imaging

TitleIn vivo evaluation of retinal and callosal projections in early postnatal development and plasticity using manganese-enhanced mri and diffusion tensor imaging
Authors
KeywordsDiffusion tensor imaging
Early postnatal development
Manganese-enhanced MRI
Plasticity
Retinal projection
Visual callosal projection
Issue Date2012
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimg
Citation
Neuroimage, 2012, v. 59 n. 3, p. 2274-2283 How to Cite?
AbstractThe rodents are an excellent model for understanding the development and plasticity of the visual system. In this study, we explored the feasibility of Mn-enhanced MRI (MEMRI) and diffusion tensor imaging (DTI) at 7T for in vivo and longitudinal assessments of the retinal and callosal pathways in normal neonatal rodent brains and after early postnatal visual impairments. Along the retinal pathways, unilateral intravitreal Mn 2+ injection resulted in Mn 2+ uptake and transport in normal neonatal visual brains at postnatal days (P) 1, 5 and 10 with faster Mn 2+ clearance than the adult brains at P60. The reorganization of retinocollicular projections was also detected by significant Mn 2+ enhancement by 2%-10% in the ipsilateral superior colliculus (SC) of normal neonatal rats, normal adult mice and adult rats after neonatal monocular enucleation (ME) but not in normal adult rats or adult rats after monocular deprivation (MD). DTI showed a significantly higher fractional anisotropy (FA) by 21% in the optic nerve projected from the remaining eye of ME rats compared to normal rats at 6weeks old, likely as a result of the retention of axons from the ipsilaterally uncrossed retinal ganglion cells, whereas the anterior and posterior retinal pathways projected from the enucleated or deprived eyes possessed lower FA after neonatal binocular enucleation (BE), ME and MD by 22%-56%, 18%-46% and 11%-15% respectively compared to normal rats, indicative of neurodegeneration or immaturity of white matter tracts. Along the visual callosal pathways, intracortical Mn 2+ injection to the visual cortex of BE rats enhanced a larger projection volume by about 74% in the V1/V2 transition zone of the contralateral hemisphere compared to normal rats, without apparent DTI parametric changes in the splenium of corpus callosum. This suggested an adaptive change in interhemispheric connections and spatial specificity in the visual cortex upon early blindness. The results of this study may help determine the mechanisms of axonal uptake and transport, microstructural reorganization and functional activities in the living visual brains during development, diseases, plasticity and early interventions in a global and longitudinal setting. © 2011 Elsevier Inc.
Persistent Identifierhttp://hdl.handle.net/10722/155721
ISSN
2015 Impact Factor: 5.463
2015 SCImago Journal Rankings: 4.464
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong Research Grant CouncilGRF HKU 7793/08M
GRF HKU 7808/09M
Funding Information:

This work was supported by the Hong Kong Research Grant Council (GRF HKU 7793/08M and GRF HKU 7808/09M).

References

 

DC FieldValueLanguage
dc.contributor.authorChan, KCen_HK
dc.contributor.authorCheng, JSen_HK
dc.contributor.authorFan, Sen_HK
dc.contributor.authorZhou, IYen_HK
dc.contributor.authorYang, Jen_HK
dc.contributor.authorWu, EXen_HK
dc.date.accessioned2012-08-08T08:35:00Z-
dc.date.available2012-08-08T08:35:00Z-
dc.date.issued2012en_HK
dc.identifier.citationNeuroimage, 2012, v. 59 n. 3, p. 2274-2283en_HK
dc.identifier.issn1053-8119en_HK
dc.identifier.urihttp://hdl.handle.net/10722/155721-
dc.description.abstractThe rodents are an excellent model for understanding the development and plasticity of the visual system. In this study, we explored the feasibility of Mn-enhanced MRI (MEMRI) and diffusion tensor imaging (DTI) at 7T for in vivo and longitudinal assessments of the retinal and callosal pathways in normal neonatal rodent brains and after early postnatal visual impairments. Along the retinal pathways, unilateral intravitreal Mn 2+ injection resulted in Mn 2+ uptake and transport in normal neonatal visual brains at postnatal days (P) 1, 5 and 10 with faster Mn 2+ clearance than the adult brains at P60. The reorganization of retinocollicular projections was also detected by significant Mn 2+ enhancement by 2%-10% in the ipsilateral superior colliculus (SC) of normal neonatal rats, normal adult mice and adult rats after neonatal monocular enucleation (ME) but not in normal adult rats or adult rats after monocular deprivation (MD). DTI showed a significantly higher fractional anisotropy (FA) by 21% in the optic nerve projected from the remaining eye of ME rats compared to normal rats at 6weeks old, likely as a result of the retention of axons from the ipsilaterally uncrossed retinal ganglion cells, whereas the anterior and posterior retinal pathways projected from the enucleated or deprived eyes possessed lower FA after neonatal binocular enucleation (BE), ME and MD by 22%-56%, 18%-46% and 11%-15% respectively compared to normal rats, indicative of neurodegeneration or immaturity of white matter tracts. Along the visual callosal pathways, intracortical Mn 2+ injection to the visual cortex of BE rats enhanced a larger projection volume by about 74% in the V1/V2 transition zone of the contralateral hemisphere compared to normal rats, without apparent DTI parametric changes in the splenium of corpus callosum. This suggested an adaptive change in interhemispheric connections and spatial specificity in the visual cortex upon early blindness. The results of this study may help determine the mechanisms of axonal uptake and transport, microstructural reorganization and functional activities in the living visual brains during development, diseases, plasticity and early interventions in a global and longitudinal setting. © 2011 Elsevier Inc.en_HK
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimgen_HK
dc.relation.ispartofNeuroImageen_HK
dc.subjectDiffusion tensor imagingen_HK
dc.subjectEarly postnatal developmenten_HK
dc.subjectManganese-enhanced MRIen_HK
dc.subjectPlasticityen_HK
dc.subjectRetinal projectionen_HK
dc.subjectVisual callosal projectionen_HK
dc.subject.meshCorpus Callosum - anatomy and histology - growth and development - pathologyen_US
dc.subject.meshDiffusion Tensor Imaging - methodsen_US
dc.subject.meshManganese - diagnostic useen_US
dc.subject.meshRetina - anatomy and histology - growth and development - pathologyen_US
dc.subject.meshVisual Pathways - anatomy and histology - growth and development - pathologyen_US
dc.titleIn vivo evaluation of retinal and callosal projections in early postnatal development and plasticity using manganese-enhanced mri and diffusion tensor imagingen_HK
dc.typeArticleen_HK
dc.identifier.emailZhou, IY: izhou@hku.hken_HK
dc.identifier.emailWu, EX: ewu1@hkucc.hku.hken_HK
dc.identifier.authorityZhou, IY=rp01739en_HK
dc.identifier.authorityWu, EX=rp00193en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.neuroimage.2011.09.055en_HK
dc.identifier.pmid21985904-
dc.identifier.scopuseid_2-s2.0-84855432496en_HK
dc.identifier.hkuros206789-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84855432496&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume59en_HK
dc.identifier.issue3en_HK
dc.identifier.spage2274en_HK
dc.identifier.epage2283en_HK
dc.identifier.isiWOS:000299494000029-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChan, KC=34968940300en_HK
dc.identifier.scopusauthoridCheng, JS=55443910700en_HK
dc.identifier.scopusauthoridFan, S=36514618100en_HK
dc.identifier.scopusauthoridZhou, IY=35424838500en_HK
dc.identifier.scopusauthoridYang, J=53464472800en_HK
dc.identifier.scopusauthoridWu, EX=7202128034en_HK
dc.identifier.citeulike9860784-

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