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Article: In vivo evaluation of retinal and callosal projections in early postnatal development and plasticity using manganese-enhanced mri and diffusion tensor imaging
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TitleIn vivo evaluation of retinal and callosal projections in early postnatal development and plasticity using manganese-enhanced mri and diffusion tensor imaging
 
AuthorsChan, KC1 1 2 3
Cheng, JS1 1
Fan, S1 1
Zhou, IY1 1
Yang, J4
Wu, EX1 1 1
 
KeywordsDiffusion tensor imaging
Early postnatal development
Manganese-enhanced MRI
Plasticity
Retinal projection
Visual callosal projection
 
Issue Date2012
 
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimg
 
CitationNeuroimage, 2012, v. 59 n. 3, p. 2274-2283 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.neuroimage.2011.09.055
 
AbstractThe rodents are an excellent model for understanding the development and plasticity of the visual system. In this study, we explored the feasibility of Mn-enhanced MRI (MEMRI) and diffusion tensor imaging (DTI) at 7T for in vivo and longitudinal assessments of the retinal and callosal pathways in normal neonatal rodent brains and after early postnatal visual impairments. Along the retinal pathways, unilateral intravitreal Mn 2+ injection resulted in Mn 2+ uptake and transport in normal neonatal visual brains at postnatal days (P) 1, 5 and 10 with faster Mn 2+ clearance than the adult brains at P60. The reorganization of retinocollicular projections was also detected by significant Mn 2+ enhancement by 2%-10% in the ipsilateral superior colliculus (SC) of normal neonatal rats, normal adult mice and adult rats after neonatal monocular enucleation (ME) but not in normal adult rats or adult rats after monocular deprivation (MD). DTI showed a significantly higher fractional anisotropy (FA) by 21% in the optic nerve projected from the remaining eye of ME rats compared to normal rats at 6weeks old, likely as a result of the retention of axons from the ipsilaterally uncrossed retinal ganglion cells, whereas the anterior and posterior retinal pathways projected from the enucleated or deprived eyes possessed lower FA after neonatal binocular enucleation (BE), ME and MD by 22%-56%, 18%-46% and 11%-15% respectively compared to normal rats, indicative of neurodegeneration or immaturity of white matter tracts. Along the visual callosal pathways, intracortical Mn 2+ injection to the visual cortex of BE rats enhanced a larger projection volume by about 74% in the V1/V2 transition zone of the contralateral hemisphere compared to normal rats, without apparent DTI parametric changes in the splenium of corpus callosum. This suggested an adaptive change in interhemispheric connections and spatial specificity in the visual cortex upon early blindness. The results of this study may help determine the mechanisms of axonal uptake and transport, microstructural reorganization and functional activities in the living visual brains during development, diseases, plasticity and early interventions in a global and longitudinal setting. © 2011 Elsevier Inc.
 
ISSN1053-8119
2012 Impact Factor: 6.252
2012 SCImago Journal Rankings: 3.164
 
DOIhttp://dx.doi.org/10.1016/j.neuroimage.2011.09.055
 
ISI Accession Number IDWOS:000299494000029
Funding AgencyGrant Number
Hong Kong Research Grant CouncilGRF HKU 7793/08M
GRF HKU 7808/09M
Funding Information:

This work was supported by the Hong Kong Research Grant Council (GRF HKU 7793/08M and GRF HKU 7808/09M).

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorChan, KC
 
dc.contributor.authorCheng, JS
 
dc.contributor.authorFan, S
 
dc.contributor.authorZhou, IY
 
dc.contributor.authorYang, J
 
dc.contributor.authorWu, EX
 
dc.date.accessioned2012-08-08T08:35:00Z
 
dc.date.available2012-08-08T08:35:00Z
 
dc.date.issued2012
 
dc.description.abstractThe rodents are an excellent model for understanding the development and plasticity of the visual system. In this study, we explored the feasibility of Mn-enhanced MRI (MEMRI) and diffusion tensor imaging (DTI) at 7T for in vivo and longitudinal assessments of the retinal and callosal pathways in normal neonatal rodent brains and after early postnatal visual impairments. Along the retinal pathways, unilateral intravitreal Mn 2+ injection resulted in Mn 2+ uptake and transport in normal neonatal visual brains at postnatal days (P) 1, 5 and 10 with faster Mn 2+ clearance than the adult brains at P60. The reorganization of retinocollicular projections was also detected by significant Mn 2+ enhancement by 2%-10% in the ipsilateral superior colliculus (SC) of normal neonatal rats, normal adult mice and adult rats after neonatal monocular enucleation (ME) but not in normal adult rats or adult rats after monocular deprivation (MD). DTI showed a significantly higher fractional anisotropy (FA) by 21% in the optic nerve projected from the remaining eye of ME rats compared to normal rats at 6weeks old, likely as a result of the retention of axons from the ipsilaterally uncrossed retinal ganglion cells, whereas the anterior and posterior retinal pathways projected from the enucleated or deprived eyes possessed lower FA after neonatal binocular enucleation (BE), ME and MD by 22%-56%, 18%-46% and 11%-15% respectively compared to normal rats, indicative of neurodegeneration or immaturity of white matter tracts. Along the visual callosal pathways, intracortical Mn 2+ injection to the visual cortex of BE rats enhanced a larger projection volume by about 74% in the V1/V2 transition zone of the contralateral hemisphere compared to normal rats, without apparent DTI parametric changes in the splenium of corpus callosum. This suggested an adaptive change in interhemispheric connections and spatial specificity in the visual cortex upon early blindness. The results of this study may help determine the mechanisms of axonal uptake and transport, microstructural reorganization and functional activities in the living visual brains during development, diseases, plasticity and early interventions in a global and longitudinal setting. © 2011 Elsevier Inc.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationNeuroimage, 2012, v. 59 n. 3, p. 2274-2283 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.neuroimage.2011.09.055
 
dc.identifier.citeulike9860784
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.neuroimage.2011.09.055
 
dc.identifier.epage2283
 
dc.identifier.hkuros206789
 
dc.identifier.isiWOS:000299494000029
Funding AgencyGrant Number
Hong Kong Research Grant CouncilGRF HKU 7793/08M
GRF HKU 7808/09M
Funding Information:

This work was supported by the Hong Kong Research Grant Council (GRF HKU 7793/08M and GRF HKU 7808/09M).

 
dc.identifier.issn1053-8119
2012 Impact Factor: 6.252
2012 SCImago Journal Rankings: 3.164
 
dc.identifier.issue3
 
dc.identifier.pmid21985904
 
dc.identifier.scopuseid_2-s2.0-84855432496
 
dc.identifier.spage2274
 
dc.identifier.urihttp://hdl.handle.net/10722/155721
 
dc.identifier.volume59
 
dc.languageeng
 
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimg
 
dc.publisher.placeUnited States
 
dc.relation.ispartofNeuroImage
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshCorpus Callosum - anatomy and histology - growth and development - pathology
 
dc.subject.meshDiffusion Tensor Imaging - methods
 
dc.subject.meshManganese - diagnostic use
 
dc.subject.meshRetina - anatomy and histology - growth and development - pathology
 
dc.subject.meshVisual Pathways - anatomy and histology - growth and development - pathology
 
dc.subjectDiffusion tensor imaging
 
dc.subjectEarly postnatal development
 
dc.subjectManganese-enhanced MRI
 
dc.subjectPlasticity
 
dc.subjectRetinal projection
 
dc.subjectVisual callosal projection
 
dc.titleIn vivo evaluation of retinal and callosal projections in early postnatal development and plasticity using manganese-enhanced mri and diffusion tensor imaging
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong
  2. Eye and Ear Institute
  3. Carnegie Mellon University
  4. Xi'an Jiaotong University