Article: Learning and memory alterations are associated with hippocampal N-acetylaspartate in a rate model of depression as measured by H-MRS
| Title | Learning and memory alterations are associated with hippocampal N-acetylaspartate in a rate model of depression as measured by H-MRS | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Authors | Xi, G2 Hui, J2 Zhang, Z2 Liu, S2 Zhang, X2 Teng, G2 Chan, KC1 Wu, EX1 Nie, B3 Shan, B3 Li, L4 Reynolds, GP5 | ||||||||
| Issue Date | 2011 | ||||||||
| Publisher | Public Library of Science. The Journal's web site is located at http://www.plosone.org/home.action | ||||||||
| Citation | PLoS One, 2011, v. 6 n. 12, article no. e28686 [How to Cite?] DOI: http://dx.doi.org/10.1371/journal.pone.0028686 | ||||||||
| Abstract | It is generally accepted that cognitive processes, such as learning and memory, are affected in depression. The present study used a rat model of depression, chronic unpredictable mild stress (CUMS), to determine whether hippocampal volume and neurochemical changes were involved in learning and memory alterations. A further aim was to determine whether these effects could be ameliorated by escitalopram treatment, as assessed with the non-invasive techniques of structural magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS). Our results demonstrated that CUMS had a dramatic influence on spatial cognitive performance in the Morris water maze task, and CUMS reduced the concentration of neuronal marker N-acetylaspartate (NAA) in the hippocampus. These effects could be significantly reversed by repeated administration of escitalopram. However, neither chronic stress nor escitalopram treatment influenced hippocampal volume. Of note, the learning and memory alterations of the rats were associated with right hippocampal NAA concentration. Our results indicate that in depression, NAA may be a more sensitive measure of cognitive function than hippocampal volume. | ||||||||
| ISSN | 1932-6203 2011 Impact Factor: 4.092 2011 SCImago Journal Rankings: 0.519 | ||||||||
| DOI | http://dx.doi.org/10.1371/journal.pone.0028686 | ||||||||
| ISI Accession Number ID | WOS:000298369100078
Funding Information: This research was partly supported by National Natural Science Foundation of China (No. 30770779 and No. 30825014 to ZZ; No. 30830046 to LL), National Basic Research Program of China (973 Program) (No. 2007CB512308 to ZZ; No. 2009CB918303 to LL) and National Hi-Tech Research and Development Program of China (863 Program) (No. 2008AA02Z413 to ZZ). No additional external funding received for this study. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. | ||||||||
| PubMed Central ID | PMC3237477 | ||||||||
| References | References in Scopus |
| dc.contributor.author | Xi, G | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| dc.contributor.author | Hui, J | ||||||||
| dc.contributor.author | Zhang, Z | ||||||||
| dc.contributor.author | Liu, S | ||||||||
| dc.contributor.author | Zhang, X | ||||||||
| dc.contributor.author | Teng, G | ||||||||
| dc.contributor.author | Chan, KC | ||||||||
| dc.contributor.author | Wu, EX | ||||||||
| dc.contributor.author | Nie, B | ||||||||
| dc.contributor.author | Shan, B | ||||||||
| dc.contributor.author | Li, L | ||||||||
| dc.contributor.author | Reynolds, GP | ||||||||
| dc.date.accessioned | 2012-08-08T08:34:56Z | ||||||||
| dc.date.available | 2012-08-08T08:34:56Z | ||||||||
| dc.date.issued | 2011 | ||||||||
| dc.description.abstract | It is generally accepted that cognitive processes, such as learning and memory, are affected in depression. The present study used a rat model of depression, chronic unpredictable mild stress (CUMS), to determine whether hippocampal volume and neurochemical changes were involved in learning and memory alterations. A further aim was to determine whether these effects could be ameliorated by escitalopram treatment, as assessed with the non-invasive techniques of structural magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS). Our results demonstrated that CUMS had a dramatic influence on spatial cognitive performance in the Morris water maze task, and CUMS reduced the concentration of neuronal marker N-acetylaspartate (NAA) in the hippocampus. These effects could be significantly reversed by repeated administration of escitalopram. However, neither chronic stress nor escitalopram treatment influenced hippocampal volume. Of note, the learning and memory alterations of the rats were associated with right hippocampal NAA concentration. Our results indicate that in depression, NAA may be a more sensitive measure of cognitive function than hippocampal volume. | ||||||||
| dc.description.nature | published_or_final_version | ||||||||
| dc.identifier.citation | PLoS One, 2011, v. 6 n. 12, article no. e28686 [How to Cite?] DOI: http://dx.doi.org/10.1371/journal.pone.0028686 | ||||||||
| dc.identifier.citeulike | 10209016 | ||||||||
| dc.identifier.doi | http://dx.doi.org/10.1371/journal.pone.0028686 | ||||||||
| dc.identifier.hkuros | 206809 | ||||||||
| dc.identifier.isi | WOS:000298369100078
Funding Information: This research was partly supported by National Natural Science Foundation of China (No. 30770779 and No. 30825014 to ZZ; No. 30830046 to LL), National Basic Research Program of China (973 Program) (No. 2007CB512308 to ZZ; No. 2009CB918303 to LL) and National Hi-Tech Research and Development Program of China (863 Program) (No. 2008AA02Z413 to ZZ). No additional external funding received for this study. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. | ||||||||
| dc.identifier.issn | 1932-6203 2011 Impact Factor: 4.092 2011 SCImago Journal Rankings: 0.519 | ||||||||
| dc.identifier.issue | 12, article no. e28686 | ||||||||
| dc.identifier.pmcid | PMC3237477 | ||||||||
| dc.identifier.pmid | 22194886 | ||||||||
| dc.identifier.scopus | eid_2-s2.0-83355172820 | ||||||||
| dc.identifier.uri | http://hdl.handle.net/10722/155709 | ||||||||
| dc.identifier.volume | 6 | ||||||||
| dc.language | eng | ||||||||
| dc.publisher | Public Library of Science. The Journal's web site is located at http://www.plosone.org/home.action | ||||||||
| dc.publisher.place | United States | ||||||||
| dc.relation.ispartof | PLoS One | ||||||||
| dc.relation.references | References in Scopus | ||||||||
| dc.rights | Creative Commons: Attribution 3.0 Hong Kong License | ||||||||
| dc.subject.mesh | Aspartic Acid - analogs and derivatives - metabolism | ||||||||
| dc.subject.mesh | Depression - complications - drug therapy - metabolism - physiopathology | ||||||||
| dc.subject.mesh | Hippocampus - drug effects - metabolism - pathology - physiopathology | ||||||||
| dc.subject.mesh | Magnetic Resonance Spectroscopy | ||||||||
| dc.subject.mesh | Memory - drug effects - physiology | ||||||||
| dc.title | Learning and memory alterations are associated with hippocampal N-acetylaspartate in a rate model of depression as measured by H-MRS | ||||||||
| dc.type | Article |
Author Affiliations
- The University of Hong Kong
- Southeast University
- Chinese Academy of Sciences
- Central South University China
- Sheffield Hallam University