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Article: Learning and memory alterations are associated with hippocampal N-acetylaspartate in a rate model of depression as measured by H-MRS

TitleLearning and memory alterations are associated with hippocampal N-acetylaspartate in a rate model of depression as measured by H-MRS
Authors
Issue Date2011
PublisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
Citation
PLoS One, 2011, v. 6 n. 12, article no. e28686 How to Cite?
AbstractIt is generally accepted that cognitive processes, such as learning and memory, are affected in depression. The present study used a rat model of depression, chronic unpredictable mild stress (CUMS), to determine whether hippocampal volume and neurochemical changes were involved in learning and memory alterations. A further aim was to determine whether these effects could be ameliorated by escitalopram treatment, as assessed with the non-invasive techniques of structural magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS). Our results demonstrated that CUMS had a dramatic influence on spatial cognitive performance in the Morris water maze task, and CUMS reduced the concentration of neuronal marker N-acetylaspartate (NAA) in the hippocampus. These effects could be significantly reversed by repeated administration of escitalopram. However, neither chronic stress nor escitalopram treatment influenced hippocampal volume. Of note, the learning and memory alterations of the rats were associated with right hippocampal NAA concentration. Our results indicate that in depression, NAA may be a more sensitive measure of cognitive function than hippocampal volume.
Persistent Identifierhttp://hdl.handle.net/10722/155709
ISSN
2014 Impact Factor: 3.234
2013 SCImago Journal Rankings: 1.724
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
National Natural Science Foundation of China30770779
30825014
30830046
National Basic Research Program of China (973 Program)2007CB512308
2009CB918303
National Hi-Tech Research and Development Program of China (863 Program)2008AA02Z413
Funding Information:

This research was partly supported by National Natural Science Foundation of China (No. 30770779 and No. 30825014 to ZZ; No. 30830046 to LL), National Basic Research Program of China (973 Program) (No. 2007CB512308 to ZZ; No. 2009CB918303 to LL) and National Hi-Tech Research and Development Program of China (863 Program) (No. 2008AA02Z413 to ZZ). No additional external funding received for this study. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

References

 

DC FieldValueLanguage
dc.contributor.authorXi, Gen_US
dc.contributor.authorHui, Jen_US
dc.contributor.authorZhang, Zen_US
dc.contributor.authorLiu, Sen_US
dc.contributor.authorZhang, Xen_US
dc.contributor.authorTeng, Gen_US
dc.contributor.authorChan, KCen_US
dc.contributor.authorWu, EXen_US
dc.contributor.authorNie, Ben_US
dc.contributor.authorShan, Ben_US
dc.contributor.authorLi, Len_US
dc.contributor.authorReynolds, GPen_US
dc.date.accessioned2012-08-08T08:34:56Z-
dc.date.available2012-08-08T08:34:56Z-
dc.date.issued2011en_US
dc.identifier.citationPLoS One, 2011, v. 6 n. 12, article no. e28686en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttp://hdl.handle.net/10722/155709-
dc.description.abstractIt is generally accepted that cognitive processes, such as learning and memory, are affected in depression. The present study used a rat model of depression, chronic unpredictable mild stress (CUMS), to determine whether hippocampal volume and neurochemical changes were involved in learning and memory alterations. A further aim was to determine whether these effects could be ameliorated by escitalopram treatment, as assessed with the non-invasive techniques of structural magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS). Our results demonstrated that CUMS had a dramatic influence on spatial cognitive performance in the Morris water maze task, and CUMS reduced the concentration of neuronal marker N-acetylaspartate (NAA) in the hippocampus. These effects could be significantly reversed by repeated administration of escitalopram. However, neither chronic stress nor escitalopram treatment influenced hippocampal volume. Of note, the learning and memory alterations of the rats were associated with right hippocampal NAA concentration. Our results indicate that in depression, NAA may be a more sensitive measure of cognitive function than hippocampal volume.en_US
dc.languageengen_US
dc.publisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.actionen_US
dc.relation.ispartofPLoS Oneen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshAspartic Acid - analogs and derivatives - metabolism-
dc.subject.meshDepression - complications - drug therapy - metabolism - physiopathology-
dc.subject.meshHippocampus - drug effects - metabolism - pathology - physiopathology-
dc.subject.meshMagnetic Resonance Spectroscopy-
dc.subject.meshMemory - drug effects - physiology-
dc.titleLearning and memory alterations are associated with hippocampal N-acetylaspartate in a rate model of depression as measured by H-MRSen_US
dc.typeArticleen_US
dc.identifier.emailWu, EX: ewu1@hkucc.hku.hken_US
dc.identifier.authorityWu, EX=rp00193en_US
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1371/journal.pone.0028686en_US
dc.identifier.pmid22194886-
dc.identifier.pmcidPMC3237477-
dc.identifier.scopuseid_2-s2.0-83355172820en_US
dc.identifier.hkuros206809-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-83355172820&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume6en_US
dc.identifier.issue12, article no. e28686en_US
dc.identifier.isiWOS:000298369100078-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridReynolds, GP=7201487920en_US
dc.identifier.scopusauthoridLi, L=35115169500en_US
dc.identifier.scopusauthoridShan, B=7006926463en_US
dc.identifier.scopusauthoridNie, B=28267940200en_US
dc.identifier.scopusauthoridWu, EX=7202128034en_US
dc.identifier.scopusauthoridChan, KC=34968940300en_US
dc.identifier.scopusauthoridTeng, G=7004411906en_US
dc.identifier.scopusauthoridZhang, X=35771902300en_US
dc.identifier.scopusauthoridLiu, S=36573843100en_US
dc.identifier.scopusauthoridZhang, Z=15081680700en_US
dc.identifier.scopusauthoridHui, J=36573527000en_US
dc.identifier.scopusauthoridXi, G=23669525900en_US
dc.identifier.citeulike10209016-

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