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Article: MR imaging assessment of lumbar intervertebral disk degeneration and age-related changes: apparent diffusion coefficient versus T2 quantitation
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TitleMR imaging assessment of lumbar intervertebral disk degeneration and age-related changes: apparent diffusion coefficient versus T2 quantitation
 
AuthorsNiu, G3
Yang, J3
Wang, R3
Dang, S1
Wu, EX2
Guo, Y3
 
KeywordsBackache
Diagnostic test accuracy study
Disease classification
Intermethod comparison
Ischialgia
Clinical article
Controlled study
Correlation analysis
Intervertebral disk degeneration
Lumbar disk
Nuclear magnetic resonance imaging
Quantitative analysis
 
Issue Date2011
 
PublisherAmerican Society of Neuroradiology. The Journal's web site is located at http://www.ajnr.org
 
CitationAmerican Journal of Neuroradiology, 2011, v. 32 n. 9, p. 1617-23 [How to Cite?]
DOI: http://dx.doi.org/10.3174/ajnr.A2556
 
AbstractBACKGROUND AND PURPOSE: T2 and ADC mappings are 2 quantitative MR imaging tools for assessing IVDD. This study aimed to compare these 2 measures in detecting IVDD and its age-related changes. MATERIALS AND METHODS: Thirty-seven asymptomatic volunteers and 28 patients with back pain or sciatica were examined, and their lumbar disk T2 and ADC maps were quantified via sagittal imaging protocols at 1.5T. For all participants, the Pfirrmann system was used by 2 radiologists for grading disks. T2 and ADC values in the inner portion of disks were measured, and their variances in different grades were analyzed by 1-way ANOVA testing. The ability of T2 and ADC measures to differentiate IVDD grades was compared on the basis of their ROC curves. For asymptomatic subjects, the correlations between age and the 2 MR imaging measures were assessed by the Pearson correlation test. RESULTS: Both T2 and ADC values were found to decrease with the increasing Pfirrmann grades except T2 in grade V. Significant T2 differences were seen among grades I-IV, but not between grades IV and V. There were no significant ADC differences among grades I-III. Moreover, the areas under the ROC curves differed significantly (0.95 and 0.67 for T2 and ADC, respectively). Linear regression analysis revealed that T2 yielded more significant correlation with age (r = -0.77) than ADC did (r = -0.37). CONCLUSIONS: T2 quantitation provides a more sensitive and robust approach for detecting and characterizing the early stage of IVDD and age-related disk changes.
 
DescriptionOriginal research
 
ISSN0195-6108
2013 Impact Factor: 3.675
2013 SCImago Journal Rankings: 1.773
 
DOIhttp://dx.doi.org/10.3174/ajnr.A2556
 
ISI Accession Number IDWOS:000297142700011
Funding AgencyGrant Number
National Natural Foundation of China30970797
National Basic Research Program of China (973 Program)2010CB7332603
Funding Information:

This work was supported in part by the National Natural Foundation of China (grant 30970797 to Jian Yang) and the National Basic Research Program of China (973 Program, grant 2010CB7332603).

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorNiu, G
 
dc.contributor.authorYang, J
 
dc.contributor.authorWang, R
 
dc.contributor.authorDang, S
 
dc.contributor.authorWu, EX
 
dc.contributor.authorGuo, Y
 
dc.date.accessioned2012-08-08T08:34:46Z
 
dc.date.available2012-08-08T08:34:46Z
 
dc.date.issued2011
 
dc.description.abstractBACKGROUND AND PURPOSE: T2 and ADC mappings are 2 quantitative MR imaging tools for assessing IVDD. This study aimed to compare these 2 measures in detecting IVDD and its age-related changes. MATERIALS AND METHODS: Thirty-seven asymptomatic volunteers and 28 patients with back pain or sciatica were examined, and their lumbar disk T2 and ADC maps were quantified via sagittal imaging protocols at 1.5T. For all participants, the Pfirrmann system was used by 2 radiologists for grading disks. T2 and ADC values in the inner portion of disks were measured, and their variances in different grades were analyzed by 1-way ANOVA testing. The ability of T2 and ADC measures to differentiate IVDD grades was compared on the basis of their ROC curves. For asymptomatic subjects, the correlations between age and the 2 MR imaging measures were assessed by the Pearson correlation test. RESULTS: Both T2 and ADC values were found to decrease with the increasing Pfirrmann grades except T2 in grade V. Significant T2 differences were seen among grades I-IV, but not between grades IV and V. There were no significant ADC differences among grades I-III. Moreover, the areas under the ROC curves differed significantly (0.95 and 0.67 for T2 and ADC, respectively). Linear regression analysis revealed that T2 yielded more significant correlation with age (r = -0.77) than ADC did (r = -0.37). CONCLUSIONS: T2 quantitation provides a more sensitive and robust approach for detecting and characterizing the early stage of IVDD and age-related disk changes.
 
dc.description.naturelink_to_OA_fulltext
 
dc.descriptionOriginal research
 
dc.identifier.citationAmerican Journal of Neuroradiology, 2011, v. 32 n. 9, p. 1617-23 [How to Cite?]
DOI: http://dx.doi.org/10.3174/ajnr.A2556
 
dc.identifier.doihttp://dx.doi.org/10.3174/ajnr.A2556
 
dc.identifier.epage23
 
dc.identifier.hkuros206803
 
dc.identifier.isiWOS:000297142700011
Funding AgencyGrant Number
National Natural Foundation of China30970797
National Basic Research Program of China (973 Program)2010CB7332603
Funding Information:

This work was supported in part by the National Natural Foundation of China (grant 30970797 to Jian Yang) and the National Basic Research Program of China (973 Program, grant 2010CB7332603).

 
dc.identifier.issn0195-6108
2013 Impact Factor: 3.675
2013 SCImago Journal Rankings: 1.773
 
dc.identifier.issue9
 
dc.identifier.pmid21799044
 
dc.identifier.scopuseid_2-s2.0-80054040699
 
dc.identifier.spage1617
 
dc.identifier.urihttp://hdl.handle.net/10722/155675
 
dc.identifier.volume32
 
dc.languageeng
 
dc.publisherAmerican Society of Neuroradiology. The Journal's web site is located at http://www.ajnr.org
 
dc.publisher.placeUnited States
 
dc.relation.ispartofAmerican Journal of Neuroradiology
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshYoung adult
 
dc.subject.meshSeverity of illness index
 
dc.subject.meshSensitivity and specificity
 
dc.subject.meshSciatica - Pathology
 
dc.subject.meshRoc curve
 
dc.subject.meshProspective studies
 
dc.subject.meshObserver variation
 
dc.subject.meshMiddle aged
 
dc.subject.meshMale
 
dc.subject.meshLumbar vertebrae - Pathology
 
dc.subject.meshLow back pain - Pathology
 
dc.subject.meshIntervertebral disc degeneration - Pathology
 
dc.subject.meshHumans
 
dc.subject.meshFemale
 
dc.subject.meshDiffusion magnetic resonance imaging - Methods - Statistics & numerical data
 
dc.subject.meshAging - Pathology
 
dc.subject.meshAged
 
dc.subject.meshAdult
 
dc.subjectBackache
 
dc.subjectDiagnostic test accuracy study
 
dc.subjectDisease classification
 
dc.subjectIntermethod comparison
 
dc.subjectIschialgia
 
dc.subjectClinical article
 
dc.subjectControlled study
 
dc.subjectCorrelation analysis
 
dc.subjectIntervertebral disk degeneration
 
dc.subjectLumbar disk
 
dc.subjectNuclear magnetic resonance imaging
 
dc.subjectQuantitative analysis
 
dc.titleMR imaging assessment of lumbar intervertebral disk degeneration and age-related changes: apparent diffusion coefficient versus T2 quantitation
 
dc.typeArticle
 
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Author Affiliations
  1. Xi'an Jiaotong University, School of Medicine
  2. The University of Hong Kong
  3. Xi'an Jiaotong University