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Article: MR imaging assessment of lumbar intervertebral disk degeneration and age-related changes: apparent diffusion coefficient versus T2 quantitation

TitleMR imaging assessment of lumbar intervertebral disk degeneration and age-related changes: apparent diffusion coefficient versus T2 quantitation
Authors
KeywordsBackache
Diagnostic test accuracy study
Disease classification
Intermethod comparison
Ischialgia
Clinical article
Controlled study
Correlation analysis
Intervertebral disk degeneration
Lumbar disk
Nuclear magnetic resonance imaging
Quantitative analysis
Issue Date2011
PublisherAmerican Society of Neuroradiology. The Journal's web site is located at http://www.ajnr.org
Citation
American Journal of Neuroradiology, 2011, v. 32 n. 9, p. 1617-23 How to Cite?
AbstractBACKGROUND AND PURPOSE: T2 and ADC mappings are 2 quantitative MR imaging tools for assessing IVDD. This study aimed to compare these 2 measures in detecting IVDD and its age-related changes. MATERIALS AND METHODS: Thirty-seven asymptomatic volunteers and 28 patients with back pain or sciatica were examined, and their lumbar disk T2 and ADC maps were quantified via sagittal imaging protocols at 1.5T. For all participants, the Pfirrmann system was used by 2 radiologists for grading disks. T2 and ADC values in the inner portion of disks were measured, and their variances in different grades were analyzed by 1-way ANOVA testing. The ability of T2 and ADC measures to differentiate IVDD grades was compared on the basis of their ROC curves. For asymptomatic subjects, the correlations between age and the 2 MR imaging measures were assessed by the Pearson correlation test. RESULTS: Both T2 and ADC values were found to decrease with the increasing Pfirrmann grades except T2 in grade V. Significant T2 differences were seen among grades I-IV, but not between grades IV and V. There were no significant ADC differences among grades I-III. Moreover, the areas under the ROC curves differed significantly (0.95 and 0.67 for T2 and ADC, respectively). Linear regression analysis revealed that T2 yielded more significant correlation with age (r = -0.77) than ADC did (r = -0.37). CONCLUSIONS: T2 quantitation provides a more sensitive and robust approach for detecting and characterizing the early stage of IVDD and age-related disk changes.
Persistent Identifierhttp://hdl.handle.net/10722/155675
ISSN
2014 Impact Factor: 3.589
2014 SCImago Journal Rankings: 1.627
ISI Accession Number ID
Funding AgencyGrant Number
National Natural Foundation of China30970797
National Basic Research Program of China (973 Program)2010CB7332603
Funding Information:

This work was supported in part by the National Natural Foundation of China (grant 30970797 to Jian Yang) and the National Basic Research Program of China (973 Program, grant 2010CB7332603).

References

 

DC FieldValueLanguage
dc.contributor.authorNiu, Gen_US
dc.contributor.authorYang, Jen_US
dc.contributor.authorWang, Ren_US
dc.contributor.authorDang, Sen_US
dc.contributor.authorWu, EXen_US
dc.contributor.authorGuo, Yen_US
dc.date.accessioned2012-08-08T08:34:46Z-
dc.date.available2012-08-08T08:34:46Z-
dc.date.issued2011en_US
dc.identifier.citationAmerican Journal of Neuroradiology, 2011, v. 32 n. 9, p. 1617-23en_US
dc.identifier.issn0195-6108en_US
dc.identifier.urihttp://hdl.handle.net/10722/155675-
dc.description.abstractBACKGROUND AND PURPOSE: T2 and ADC mappings are 2 quantitative MR imaging tools for assessing IVDD. This study aimed to compare these 2 measures in detecting IVDD and its age-related changes. MATERIALS AND METHODS: Thirty-seven asymptomatic volunteers and 28 patients with back pain or sciatica were examined, and their lumbar disk T2 and ADC maps were quantified via sagittal imaging protocols at 1.5T. For all participants, the Pfirrmann system was used by 2 radiologists for grading disks. T2 and ADC values in the inner portion of disks were measured, and their variances in different grades were analyzed by 1-way ANOVA testing. The ability of T2 and ADC measures to differentiate IVDD grades was compared on the basis of their ROC curves. For asymptomatic subjects, the correlations between age and the 2 MR imaging measures were assessed by the Pearson correlation test. RESULTS: Both T2 and ADC values were found to decrease with the increasing Pfirrmann grades except T2 in grade V. Significant T2 differences were seen among grades I-IV, but not between grades IV and V. There were no significant ADC differences among grades I-III. Moreover, the areas under the ROC curves differed significantly (0.95 and 0.67 for T2 and ADC, respectively). Linear regression analysis revealed that T2 yielded more significant correlation with age (r = -0.77) than ADC did (r = -0.37). CONCLUSIONS: T2 quantitation provides a more sensitive and robust approach for detecting and characterizing the early stage of IVDD and age-related disk changes.en_US
dc.languageengen_US
dc.publisherAmerican Society of Neuroradiology. The Journal's web site is located at http://www.ajnr.orgen_US
dc.relation.ispartofAmerican Journal of Neuroradiologyen_US
dc.subjectBackache-
dc.subjectDiagnostic test accuracy study-
dc.subjectDisease classification-
dc.subjectIntermethod comparison-
dc.subjectIschialgia-
dc.subjectClinical article-
dc.subjectControlled study-
dc.subjectCorrelation analysis-
dc.subjectIntervertebral disk degeneration-
dc.subjectLumbar disk-
dc.subjectNuclear magnetic resonance imaging-
dc.subjectQuantitative analysis-
dc.subject.meshYoung adulten_US
dc.subject.meshSeverity of illness indexen_US
dc.subject.meshSensitivity and specificityen_US
dc.subject.meshSciatica - Pathologyen_US
dc.subject.meshRoc curveen_US
dc.subject.meshProspective studiesen_US
dc.subject.meshObserver variationen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshMaleen_US
dc.subject.meshLumbar vertebrae - Pathologyen_US
dc.subject.meshLow back pain - Pathologyen_US
dc.subject.meshIntervertebral disc degeneration - Pathologyen_US
dc.subject.meshHumansen_US
dc.subject.meshFemaleen_US
dc.subject.meshDiffusion magnetic resonance imaging - Methods - Statistics & numerical dataen_US
dc.subject.meshAging - Pathologyen_US
dc.subject.meshAgeden_US
dc.subject.meshAdulten_US
dc.titleMR imaging assessment of lumbar intervertebral disk degeneration and age-related changes: apparent diffusion coefficient versus T2 quantitationen_US
dc.typeArticleen_US
dc.identifier.emailWu, EX: ewu1@hkucc.hku.hken_US
dc.identifier.emailYang, J: cjr.yangjian@vip.163.comen_US
dc.identifier.authorityWu, EX=rp00193en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.3174/ajnr.A2556en_US
dc.identifier.pmid21799044en_US
dc.identifier.scopuseid_2-s2.0-80054040699en_US
dc.identifier.hkuros206803-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80054040699&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume32en_US
dc.identifier.issue9en_US
dc.identifier.spage1617en_US
dc.identifier.epage23en_US
dc.identifier.isiWOS:000297142700011-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridGuo, Y=53263708600en_US
dc.identifier.scopusauthoridWu, EX=7202128034en_US
dc.identifier.scopusauthoridDang, S=55108712000en_US
dc.identifier.scopusauthoridWang, R=53980713600en_US
dc.identifier.scopusauthoridYang, J=37098357500en_US
dc.identifier.scopusauthoridNiu, G=35273273000en_US

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