Article: MR imaging assessment of lumbar intervertebral disk degeneration and age-related changes: apparent diffusion coefficient versus T2 quantitation
| Title | MR imaging assessment of lumbar intervertebral disk degeneration and age-related changes: apparent diffusion coefficient versus T2 quantitation | ||||||
|---|---|---|---|---|---|---|---|
| Authors | Niu, G3 Yang, J3 Wang, R3 Dang, S1 Wu, EX2 Guo, Y3 | ||||||
| Keywords | Backache Diagnostic test accuracy study Disease classification Intermethod comparison Ischialgia Clinical article Controlled study Correlation analysis Intervertebral disk degeneration Lumbar disk Nuclear magnetic resonance imaging Quantitative analysis | ||||||
| Issue Date | 2011 | ||||||
| Publisher | American Society of Neuroradiology. The Journal's web site is located at http://www.ajnr.org | ||||||
| Citation | American Journal of Neuroradiology, 2011, v. 32 n. 9, p. 1617-23 [How to Cite?] DOI: http://dx.doi.org/10.3174/ajnr.A2556 | ||||||
| Abstract | BACKGROUND AND PURPOSE: T2 and ADC mappings are 2 quantitative MR imaging tools for assessing IVDD. This study aimed to compare these 2 measures in detecting IVDD and its age-related changes. MATERIALS AND METHODS: Thirty-seven asymptomatic volunteers and 28 patients with back pain or sciatica were examined, and their lumbar disk T2 and ADC maps were quantified via sagittal imaging protocols at 1.5T. For all participants, the Pfirrmann system was used by 2 radiologists for grading disks. T2 and ADC values in the inner portion of disks were measured, and their variances in different grades were analyzed by 1-way ANOVA testing. The ability of T2 and ADC measures to differentiate IVDD grades was compared on the basis of their ROC curves. For asymptomatic subjects, the correlations between age and the 2 MR imaging measures were assessed by the Pearson correlation test. RESULTS: Both T2 and ADC values were found to decrease with the increasing Pfirrmann grades except T2 in grade V. Significant T2 differences were seen among grades I-IV, but not between grades IV and V. There were no significant ADC differences among grades I-III. Moreover, the areas under the ROC curves differed significantly (0.95 and 0.67 for T2 and ADC, respectively). Linear regression analysis revealed that T2 yielded more significant correlation with age (r = -0.77) than ADC did (r = -0.37). CONCLUSIONS: T2 quantitation provides a more sensitive and robust approach for detecting and characterizing the early stage of IVDD and age-related disk changes. | ||||||
| Description | Original research | ||||||
| ISSN | 0195-6108 2011 Impact Factor: 2.928 2011 SCImago Journal Rankings: 0.255 | ||||||
| DOI | http://dx.doi.org/10.3174/ajnr.A2556 | ||||||
| ISI Accession Number ID | WOS:000297142700011
Funding Information: This work was supported in part by the National Natural Foundation of China (grant 30970797 to Jian Yang) and the National Basic Research Program of China (973 Program, grant 2010CB7332603). | ||||||
| References | References in Scopus |
| dc.contributor.author | Niu, G | ||||||
|---|---|---|---|---|---|---|---|
| dc.contributor.author | Yang, J | ||||||
| dc.contributor.author | Wang, R | ||||||
| dc.contributor.author | Dang, S | ||||||
| dc.contributor.author | Wu, EX | ||||||
| dc.contributor.author | Guo, Y | ||||||
| dc.date.accessioned | 2012-08-08T08:34:46Z | ||||||
| dc.date.available | 2012-08-08T08:34:46Z | ||||||
| dc.date.issued | 2011 | ||||||
| dc.description.abstract | BACKGROUND AND PURPOSE: T2 and ADC mappings are 2 quantitative MR imaging tools for assessing IVDD. This study aimed to compare these 2 measures in detecting IVDD and its age-related changes. MATERIALS AND METHODS: Thirty-seven asymptomatic volunteers and 28 patients with back pain or sciatica were examined, and their lumbar disk T2 and ADC maps were quantified via sagittal imaging protocols at 1.5T. For all participants, the Pfirrmann system was used by 2 radiologists for grading disks. T2 and ADC values in the inner portion of disks were measured, and their variances in different grades were analyzed by 1-way ANOVA testing. The ability of T2 and ADC measures to differentiate IVDD grades was compared on the basis of their ROC curves. For asymptomatic subjects, the correlations between age and the 2 MR imaging measures were assessed by the Pearson correlation test. RESULTS: Both T2 and ADC values were found to decrease with the increasing Pfirrmann grades except T2 in grade V. Significant T2 differences were seen among grades I-IV, but not between grades IV and V. There were no significant ADC differences among grades I-III. Moreover, the areas under the ROC curves differed significantly (0.95 and 0.67 for T2 and ADC, respectively). Linear regression analysis revealed that T2 yielded more significant correlation with age (r = -0.77) than ADC did (r = -0.37). CONCLUSIONS: T2 quantitation provides a more sensitive and robust approach for detecting and characterizing the early stage of IVDD and age-related disk changes. | ||||||
| dc.description.nature | link_to_OA_fulltext | ||||||
| dc.description | Original research | ||||||
| dc.identifier.citation | American Journal of Neuroradiology, 2011, v. 32 n. 9, p. 1617-23 [How to Cite?] DOI: http://dx.doi.org/10.3174/ajnr.A2556 | ||||||
| dc.identifier.doi | http://dx.doi.org/10.3174/ajnr.A2556 | ||||||
| dc.identifier.epage | 23 | ||||||
| dc.identifier.hkuros | 206803 | ||||||
| dc.identifier.isi | WOS:000297142700011
Funding Information: This work was supported in part by the National Natural Foundation of China (grant 30970797 to Jian Yang) and the National Basic Research Program of China (973 Program, grant 2010CB7332603). | ||||||
| dc.identifier.issn | 0195-6108 2011 Impact Factor: 2.928 2011 SCImago Journal Rankings: 0.255 | ||||||
| dc.identifier.issue | 9 | ||||||
| dc.identifier.pmid | 21799044 | ||||||
| dc.identifier.scopus | eid_2-s2.0-80054040699 | ||||||
| dc.identifier.spage | 1617 | ||||||
| dc.identifier.uri | http://hdl.handle.net/10722/155675 | ||||||
| dc.identifier.volume | 32 | ||||||
| dc.language | eng | ||||||
| dc.publisher | American Society of Neuroradiology. The Journal's web site is located at http://www.ajnr.org | ||||||
| dc.publisher.place | United States | ||||||
| dc.relation.ispartof | American Journal of Neuroradiology | ||||||
| dc.relation.references | References in Scopus | ||||||
| dc.subject.mesh | Young adult | ||||||
| dc.subject.mesh | Severity of illness index | ||||||
| dc.subject.mesh | Sensitivity and specificity | ||||||
| dc.subject.mesh | Sciatica - Pathology | ||||||
| dc.subject.mesh | Roc curve | ||||||
| dc.subject.mesh | Prospective studies | ||||||
| dc.subject.mesh | Observer variation | ||||||
| dc.subject.mesh | Middle aged | ||||||
| dc.subject.mesh | Male | ||||||
| dc.subject.mesh | Lumbar vertebrae - Pathology | ||||||
| dc.subject.mesh | Low back pain - Pathology | ||||||
| dc.subject.mesh | Intervertebral disc degeneration - Pathology | ||||||
| dc.subject.mesh | Humans | ||||||
| dc.subject.mesh | Female | ||||||
| dc.subject.mesh | Diffusion magnetic resonance imaging - Methods - Statistics & numerical data | ||||||
| dc.subject.mesh | Aging - Pathology | ||||||
| dc.subject.mesh | Aged | ||||||
| dc.subject.mesh | Adult | ||||||
| dc.subject | Backache | ||||||
| dc.subject | Diagnostic test accuracy study | ||||||
| dc.subject | Disease classification | ||||||
| dc.subject | Intermethod comparison | ||||||
| dc.subject | Ischialgia | ||||||
| dc.subject | Clinical article | ||||||
| dc.subject | Controlled study | ||||||
| dc.subject | Correlation analysis | ||||||
| dc.subject | Intervertebral disk degeneration | ||||||
| dc.subject | Lumbar disk | ||||||
| dc.subject | Nuclear magnetic resonance imaging | ||||||
| dc.subject | Quantitative analysis | ||||||
| dc.title | MR imaging assessment of lumbar intervertebral disk degeneration and age-related changes: apparent diffusion coefficient versus T2 quantitation | ||||||
| dc.type | Article |
Author Affiliations
- Xi'an Jiaotong University, School of Medicine
- The University of Hong Kong
- Xi'an Jiaotong University