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Article: BOLD responses in the superior colliculus and lateral geniculate nucleus of the rat viewing an apparent motion stimulus

TitleBOLD responses in the superior colliculus and lateral geniculate nucleus of the rat viewing an apparent motion stimulus
Authors
KeywordsBOLD
FMRI
Lateral geniculate nucleus
Motion
Rat
Superior colliculus
Issue Date2011
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimg
Citation
Neuroimage, 2011, v. 58 n. 3, p. 878-884 How to Cite?
AbstractIn rats, the superior colliculus (SC) is a main destination for retinal ganglion cells and is an important subcortical structure for vision. Electrophysiology studies have observed that many SC neurons are highly sensitive to moving objects, but complementary non-invasive functional imaging studies with larger fields of view have been rarely conducted. In this study, BOLD fMRI is used to measure the SC and nearby lateral geniculate nucleus' (LGN) hemodynamic responses, in normal adult Sprague Dawley (SD) rats, during a dynamic visual stimulus similar to those used in long-range apparent motion studies. The stimulation paradigm consists of four light spots arranged in a linear array and turned on and off sequentially at different rates to create five effective speeds of motion (7, 14, 41, 82, and 164°/s across the visual field). Stationary periods (same light spot always on) are interleaved between the moving periods. The speed response function (SRF), the hemodynamic response amplitude at each speed tested, is measured. Significant responses are observed in the SC and LGN at all speeds. In the SC, the SRF increases monotonically from 7 to 82°/s. The minimum response amplitude occurs at 164°/s. The results suggest that the SC is sensitive to slow moving visual stimuli but the hemodynamic response is reduced at higher speeds. In the LGN, the SRF exhibits a similar trend to that of the SC, but response amplitude during 7°/s stimulation is comparable to that during 164°/s stimulation. These findings are in good agreement with previous electrophysiology studies conducted on albino rats like the SD strain. This work represents the first fMRI study of stimulus speed dependence in the SC and is also the first fMRI study of motion responsiveness in the rat. © 2011 Elsevier Inc.
Persistent Identifierhttp://hdl.handle.net/10722/155649
ISSN
2014 Impact Factor: 6.357
2014 SCImago Journal Rankings: 3.549
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLau, Cen_HK
dc.contributor.authorZhang, JWen_HK
dc.contributor.authorXing, KKen_HK
dc.contributor.authorZhou, IYen_HK
dc.contributor.authorCheung, MMen_HK
dc.contributor.authorChan, KCen_HK
dc.contributor.authorWu, EXen_HK
dc.date.accessioned2012-08-08T08:34:40Z-
dc.date.available2012-08-08T08:34:40Z-
dc.date.issued2011en_HK
dc.identifier.citationNeuroimage, 2011, v. 58 n. 3, p. 878-884en_HK
dc.identifier.issn1053-8119en_HK
dc.identifier.urihttp://hdl.handle.net/10722/155649-
dc.description.abstractIn rats, the superior colliculus (SC) is a main destination for retinal ganglion cells and is an important subcortical structure for vision. Electrophysiology studies have observed that many SC neurons are highly sensitive to moving objects, but complementary non-invasive functional imaging studies with larger fields of view have been rarely conducted. In this study, BOLD fMRI is used to measure the SC and nearby lateral geniculate nucleus' (LGN) hemodynamic responses, in normal adult Sprague Dawley (SD) rats, during a dynamic visual stimulus similar to those used in long-range apparent motion studies. The stimulation paradigm consists of four light spots arranged in a linear array and turned on and off sequentially at different rates to create five effective speeds of motion (7, 14, 41, 82, and 164°/s across the visual field). Stationary periods (same light spot always on) are interleaved between the moving periods. The speed response function (SRF), the hemodynamic response amplitude at each speed tested, is measured. Significant responses are observed in the SC and LGN at all speeds. In the SC, the SRF increases monotonically from 7 to 82°/s. The minimum response amplitude occurs at 164°/s. The results suggest that the SC is sensitive to slow moving visual stimuli but the hemodynamic response is reduced at higher speeds. In the LGN, the SRF exhibits a similar trend to that of the SC, but response amplitude during 7°/s stimulation is comparable to that during 164°/s stimulation. These findings are in good agreement with previous electrophysiology studies conducted on albino rats like the SD strain. This work represents the first fMRI study of stimulus speed dependence in the SC and is also the first fMRI study of motion responsiveness in the rat. © 2011 Elsevier Inc.en_HK
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimgen_HK
dc.relation.ispartofNeuroImageen_HK
dc.subjectBOLDen_HK
dc.subjectFMRIen_HK
dc.subjectLateral geniculate nucleusen_HK
dc.subjectMotionen_HK
dc.subjectRaten_HK
dc.subjectSuperior colliculusen_HK
dc.subject.meshAnimalsen_US
dc.subject.meshBrain Mappingen_US
dc.subject.meshGeniculate Bodies - physiologyen_US
dc.subject.meshMotion Perception - physiologyen_US
dc.subject.meshSuperior Colliculi - physiologyen_US
dc.titleBOLD responses in the superior colliculus and lateral geniculate nucleus of the rat viewing an apparent motion stimulusen_HK
dc.typeArticleen_HK
dc.identifier.emailZhou, IY: izhou@hku.hken_HK
dc.identifier.emailWu, EX: ewu1@hkucc.hku.hken_HK
dc.identifier.authorityZhou, IY=rp01739en_HK
dc.identifier.authorityWu, EX=rp00193en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.neuroimage.2011.06.055en_HK
dc.identifier.pmid21741483en_HK
dc.identifier.scopuseid_2-s2.0-80052146570en_HK
dc.identifier.hkuros206788-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80052146570&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume58en_HK
dc.identifier.issue3en_HK
dc.identifier.spage878en_HK
dc.identifier.epage884en_HK
dc.identifier.isiWOS:000294940700019-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLau, C=36655866600en_HK
dc.identifier.scopusauthoridZhang, JW=50362306900en_HK
dc.identifier.scopusauthoridXing, KK=35886305100en_HK
dc.identifier.scopusauthoridZhou, IY=35424838500en_HK
dc.identifier.scopusauthoridCheung, MM=24333907800en_HK
dc.identifier.scopusauthoridChan, KC=34968940300en_HK
dc.identifier.scopusauthoridWu, EX=7202128034en_HK
dc.identifier.citeulike9544491-

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