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Article: BOLD responses in the superior colliculus and lateral geniculate nucleus of the rat viewing an apparent motion stimulus
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TitleBOLD responses in the superior colliculus and lateral geniculate nucleus of the rat viewing an apparent motion stimulus
 
AuthorsLau, C1
Zhang, JW1
Xing, KK1
Zhou, IY1
Cheung, MM1
Chan, KC1
Wu, EX1
 
KeywordsBOLD
FMRI
Lateral geniculate nucleus
Motion
Rat
Superior colliculus
 
Issue Date2011
 
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimg
 
CitationNeuroimage, 2011, v. 58 n. 3, p. 878-884 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.neuroimage.2011.06.055
 
AbstractIn rats, the superior colliculus (SC) is a main destination for retinal ganglion cells and is an important subcortical structure for vision. Electrophysiology studies have observed that many SC neurons are highly sensitive to moving objects, but complementary non-invasive functional imaging studies with larger fields of view have been rarely conducted. In this study, BOLD fMRI is used to measure the SC and nearby lateral geniculate nucleus' (LGN) hemodynamic responses, in normal adult Sprague Dawley (SD) rats, during a dynamic visual stimulus similar to those used in long-range apparent motion studies. The stimulation paradigm consists of four light spots arranged in a linear array and turned on and off sequentially at different rates to create five effective speeds of motion (7, 14, 41, 82, and 164°/s across the visual field). Stationary periods (same light spot always on) are interleaved between the moving periods. The speed response function (SRF), the hemodynamic response amplitude at each speed tested, is measured. Significant responses are observed in the SC and LGN at all speeds. In the SC, the SRF increases monotonically from 7 to 82°/s. The minimum response amplitude occurs at 164°/s. The results suggest that the SC is sensitive to slow moving visual stimuli but the hemodynamic response is reduced at higher speeds. In the LGN, the SRF exhibits a similar trend to that of the SC, but response amplitude during 7°/s stimulation is comparable to that during 164°/s stimulation. These findings are in good agreement with previous electrophysiology studies conducted on albino rats like the SD strain. This work represents the first fMRI study of stimulus speed dependence in the SC and is also the first fMRI study of motion responsiveness in the rat. © 2011 Elsevier Inc.
 
ISSN1053-8119
2013 Impact Factor: 6.132
 
DOIhttp://dx.doi.org/10.1016/j.neuroimage.2011.06.055
 
ISI Accession Number IDWOS:000294940700019
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorLau, C
 
dc.contributor.authorZhang, JW
 
dc.contributor.authorXing, KK
 
dc.contributor.authorZhou, IY
 
dc.contributor.authorCheung, MM
 
dc.contributor.authorChan, KC
 
dc.contributor.authorWu, EX
 
dc.date.accessioned2012-08-08T08:34:40Z
 
dc.date.available2012-08-08T08:34:40Z
 
dc.date.issued2011
 
dc.description.abstractIn rats, the superior colliculus (SC) is a main destination for retinal ganglion cells and is an important subcortical structure for vision. Electrophysiology studies have observed that many SC neurons are highly sensitive to moving objects, but complementary non-invasive functional imaging studies with larger fields of view have been rarely conducted. In this study, BOLD fMRI is used to measure the SC and nearby lateral geniculate nucleus' (LGN) hemodynamic responses, in normal adult Sprague Dawley (SD) rats, during a dynamic visual stimulus similar to those used in long-range apparent motion studies. The stimulation paradigm consists of four light spots arranged in a linear array and turned on and off sequentially at different rates to create five effective speeds of motion (7, 14, 41, 82, and 164°/s across the visual field). Stationary periods (same light spot always on) are interleaved between the moving periods. The speed response function (SRF), the hemodynamic response amplitude at each speed tested, is measured. Significant responses are observed in the SC and LGN at all speeds. In the SC, the SRF increases monotonically from 7 to 82°/s. The minimum response amplitude occurs at 164°/s. The results suggest that the SC is sensitive to slow moving visual stimuli but the hemodynamic response is reduced at higher speeds. In the LGN, the SRF exhibits a similar trend to that of the SC, but response amplitude during 7°/s stimulation is comparable to that during 164°/s stimulation. These findings are in good agreement with previous electrophysiology studies conducted on albino rats like the SD strain. This work represents the first fMRI study of stimulus speed dependence in the SC and is also the first fMRI study of motion responsiveness in the rat. © 2011 Elsevier Inc.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationNeuroimage, 2011, v. 58 n. 3, p. 878-884 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.neuroimage.2011.06.055
 
dc.identifier.citeulike9544491
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.neuroimage.2011.06.055
 
dc.identifier.epage884
 
dc.identifier.hkuros206788
 
dc.identifier.isiWOS:000294940700019
 
dc.identifier.issn1053-8119
2013 Impact Factor: 6.132
 
dc.identifier.issue3
 
dc.identifier.pmid21741483
 
dc.identifier.scopuseid_2-s2.0-80052146570
 
dc.identifier.spage878
 
dc.identifier.urihttp://hdl.handle.net/10722/155649
 
dc.identifier.volume58
 
dc.languageeng
 
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimg
 
dc.publisher.placeUnited States
 
dc.relation.ispartofNeuroImage
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAnimals
 
dc.subject.meshBrain Mapping
 
dc.subject.meshGeniculate Bodies - physiology
 
dc.subject.meshMotion Perception - physiology
 
dc.subject.meshSuperior Colliculi - physiology
 
dc.subjectBOLD
 
dc.subjectFMRI
 
dc.subjectLateral geniculate nucleus
 
dc.subjectMotion
 
dc.subjectRat
 
dc.subjectSuperior colliculus
 
dc.titleBOLD responses in the superior colliculus and lateral geniculate nucleus of the rat viewing an apparent motion stimulus
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong