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Article: Transmural heterogeneity of left ventricular myocardium remodeling in postinfarct porcine model revealed by MR diffusion tensor imaging

TitleTransmural heterogeneity of left ventricular myocardium remodeling in postinfarct porcine model revealed by MR diffusion tensor imaging
Authors
Issue Date2011
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/1053-1807/
Citation
Journal of Magnetic Resonance Imaging, 2011, v. 34 n. 1, p. 43-49 How to Cite?
AbstractPurpose: To investigate the transmural heterogeneity of left ventricular myocardium structural remodeling. Materials and Methods: Ex vivo diffusion tensor imaging (DTI) was performed in six adult porcine heart samples with apical septum infarction collected 13 weeks after permanent left anterior descending coronary artery ligation and six age-matched intact controls. Alterations in diffusion indices and myocardial fiber orientation, including fractional anisotropy (FA), mean apparent diffusion coefficient (mean ADC), axial diffusivity (γ∥), radial diffusivity (γ⊥), and fiber helix angle were investigated at five transmural zones across myocardium wall in regions adjacent and remote to the infarct. Results: In both adjacent and remote regions of infarcted hearts, FA showed no significant alteration across transmural zones compared to controls. However, mean ADC, γ∥, and γ⊥ exhibited significant decreases at endocardium zones but not epicardium zones. Moreover, myocardial fiber helix angle shifted towards left-handed orientation at all transmural zones, especially in regions adjacent to the infarct, becoming more aligned with the epicardium fiber orientation. Conclusion: These experimental DTI findings indicate that the endocardium was more vulnerable to infarction, leading to more pronounced microstructural changes during remodeling. The current DTI approach reveals additional information in delineating postinfarct remodeling process, which may provide insights into cardiac mechanics and clinical assessment of cardiac diseases. © 2011 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/155626
ISSN
2015 Impact Factor: 3.25
2015 SCImago Journal Rankings: 1.683
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong Research Grant CouncilHKU7826/10M
National 973 Basic Research Program of China2010CB732600
National Natural Science Foundation of China30900387
Natural Science Foundation of Guangdong Province9478922035-X003050
Basic Research Program of Shenzhen CityJC200903170437A
Funding Information:

Contract grant sponsor: Hong Kong Research Grant Council; Contract grant number: HKU7826/10M: Contract grant sponsor: National 973 Basic Research Program of China; Contract grant number: 2010CB732600; Contract grant sponsor: National Natural Science Foundation of China; Contract grant number: 30900387; Contract grant sponsor: Natural Science Foundation of Guangdong Province; Contract grant number: 9478922035-X003050; Contract grant sponsor: Basic Research Program of Shenzhen City; Contract grant number: JC200903170437A.

References

 

DC FieldValueLanguage
dc.contributor.authorWu, Yen_US
dc.contributor.authorZhang, LJen_US
dc.contributor.authorZou, Cen_US
dc.contributor.authorTse, HFen_US
dc.contributor.authorWu, EXen_US
dc.date.accessioned2012-08-08T08:34:26Z-
dc.date.available2012-08-08T08:34:26Z-
dc.date.issued2011en_US
dc.identifier.citationJournal of Magnetic Resonance Imaging, 2011, v. 34 n. 1, p. 43-49en_US
dc.identifier.issn1053-1807en_US
dc.identifier.urihttp://hdl.handle.net/10722/155626-
dc.description.abstractPurpose: To investigate the transmural heterogeneity of left ventricular myocardium structural remodeling. Materials and Methods: Ex vivo diffusion tensor imaging (DTI) was performed in six adult porcine heart samples with apical septum infarction collected 13 weeks after permanent left anterior descending coronary artery ligation and six age-matched intact controls. Alterations in diffusion indices and myocardial fiber orientation, including fractional anisotropy (FA), mean apparent diffusion coefficient (mean ADC), axial diffusivity (γ∥), radial diffusivity (γ⊥), and fiber helix angle were investigated at five transmural zones across myocardium wall in regions adjacent and remote to the infarct. Results: In both adjacent and remote regions of infarcted hearts, FA showed no significant alteration across transmural zones compared to controls. However, mean ADC, γ∥, and γ⊥ exhibited significant decreases at endocardium zones but not epicardium zones. Moreover, myocardial fiber helix angle shifted towards left-handed orientation at all transmural zones, especially in regions adjacent to the infarct, becoming more aligned with the epicardium fiber orientation. Conclusion: These experimental DTI findings indicate that the endocardium was more vulnerable to infarction, leading to more pronounced microstructural changes during remodeling. The current DTI approach reveals additional information in delineating postinfarct remodeling process, which may provide insights into cardiac mechanics and clinical assessment of cardiac diseases. © 2011 Wiley-Liss, Inc.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/1053-1807/en_US
dc.relation.ispartofJournal of Magnetic Resonance Imagingen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCell Deathen_US
dc.subject.meshCoronary Vessels - Pathology - Surgeryen_US
dc.subject.meshDiffusionen_US
dc.subject.meshDiffusion Tensor Imaging - Methodsen_US
dc.subject.meshEndocardium - Pathologyen_US
dc.subject.meshHeart Ventriclesen_US
dc.subject.meshMagnetic Resonance Imaging - Methodsen_US
dc.subject.meshMyocardial Infarction - Pathologyen_US
dc.subject.meshMyocardium - Pathologyen_US
dc.subject.meshPericardium - Pathologyen_US
dc.subject.meshSwineen_US
dc.subject.meshSwine, Miniatureen_US
dc.subject.meshVentricular Remodeling - Physiologyen_US
dc.titleTransmural heterogeneity of left ventricular myocardium remodeling in postinfarct porcine model revealed by MR diffusion tensor imagingen_US
dc.typeArticleen_US
dc.identifier.emailTse, HF:hftse@hkucc.hku.hken_US
dc.identifier.emailWu, EX:ewu1@hkucc.hku.hken_US
dc.identifier.authorityTse, HF=rp00428en_US
dc.identifier.authorityWu, EX=rp00193en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/jmri.22589en_US
dc.identifier.pmid21618331-
dc.identifier.scopuseid_2-s2.0-79959579011en_US
dc.identifier.hkuros206802-
dc.identifier.hkuros225172-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79959579011&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume34en_US
dc.identifier.issue1en_US
dc.identifier.spage43en_US
dc.identifier.epage49en_US
dc.identifier.isiWOS:000292421800005-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridWu, Y=35782366500en_US
dc.identifier.scopusauthoridZhang, LJ=54397777000en_US
dc.identifier.scopusauthoridZou, C=36635370700en_US
dc.identifier.scopusauthoridTse, HF=7006070805en_US
dc.identifier.scopusauthoridWu, EX=7202128034en_US

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