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Article: In vivo multiparametric magnetic resonance imaging and spectroscopy of rodent visual system

TitleIn vivo multiparametric magnetic resonance imaging and spectroscopy of rodent visual system
Authors
Issue Date2010
PublisherImperial College Press. The Journal's web site is located at http://www.worldscinet.com/journals/jin/jin.shtml
Citation
Journal Of Integrative Neuroscience, 2010, v. 9 n. 4, p. 477-508 How to Cite?
AbstractThe integrity of the neuronal connections between eye and brain plays an important role in the performance of the mammalian visual system. However, the developmental and pathophysiological mechanisms in the visual system are largely unexplored due to the lack of a sensitive technique for directly assessing both anterior and posterior visual pathways longitudinally under the same experimental conditions. This paper reviewed the recent use of magnetic resonance imaging and spectroscopic (MRI/MRS) methods (contrast-enhanced MRI, diffusion MRI, proton MRS and functional MRI) at high magnetic field strengths, for in vivo and global assessments of the structure, metabolism and function of the visual system in normal, developing and injured rodent brains. Using animal models of ocular diseases, optic neuropathies, developmental plasticity and neonatal hypoxic-ischemic brain injury, focus is put on the feasibility of MRI/MRS to evaluate axonal transport and cellular activity along segregated fibers of the visual pathways, to characterize lesion-induced neurodegeneration in the retina and the optic nerve and tract, to detect steady-state metabolite changes in the posterior visual nuclei, and blood-ocular dynamic exchanges in the eye, and to understand the neurovascular coupling and functions in the retina and the visual brain nuclei. These studies suggested the significant values of high-field multiparametric MRI/MRS for providing early diagnoses and comprehensive therapeutic strategies for promoting functional recovery upon partial vision loss. © 2010 Imperial College Press.
Persistent Identifierhttp://hdl.handle.net/10722/155596
ISSN
2015 Impact Factor: 0.791
2015 SCImago Journal Rankings: 0.441
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong Research Grant CouncilGRF HKU 7826/10M
Funding Information:

This work was supported by the Hong Kong Research Grant Council (GRF HKU 7826/10M).

References

 

DC FieldValueLanguage
dc.contributor.authorChan, KCen_US
dc.contributor.authorCheung, MMen_US
dc.contributor.authorWu, EXen_US
dc.date.accessioned2012-08-08T08:34:17Z-
dc.date.available2012-08-08T08:34:17Z-
dc.date.issued2010en_US
dc.identifier.citationJournal Of Integrative Neuroscience, 2010, v. 9 n. 4, p. 477-508en_US
dc.identifier.issn0219-6352en_US
dc.identifier.urihttp://hdl.handle.net/10722/155596-
dc.description.abstractThe integrity of the neuronal connections between eye and brain plays an important role in the performance of the mammalian visual system. However, the developmental and pathophysiological mechanisms in the visual system are largely unexplored due to the lack of a sensitive technique for directly assessing both anterior and posterior visual pathways longitudinally under the same experimental conditions. This paper reviewed the recent use of magnetic resonance imaging and spectroscopic (MRI/MRS) methods (contrast-enhanced MRI, diffusion MRI, proton MRS and functional MRI) at high magnetic field strengths, for in vivo and global assessments of the structure, metabolism and function of the visual system in normal, developing and injured rodent brains. Using animal models of ocular diseases, optic neuropathies, developmental plasticity and neonatal hypoxic-ischemic brain injury, focus is put on the feasibility of MRI/MRS to evaluate axonal transport and cellular activity along segregated fibers of the visual pathways, to characterize lesion-induced neurodegeneration in the retina and the optic nerve and tract, to detect steady-state metabolite changes in the posterior visual nuclei, and blood-ocular dynamic exchanges in the eye, and to understand the neurovascular coupling and functions in the retina and the visual brain nuclei. These studies suggested the significant values of high-field multiparametric MRI/MRS for providing early diagnoses and comprehensive therapeutic strategies for promoting functional recovery upon partial vision loss. © 2010 Imperial College Press.en_US
dc.languageengen_US
dc.publisherImperial College Press. The Journal's web site is located at http://www.worldscinet.com/journals/jin/jin.shtmlen_US
dc.relation.ispartofJournal of Integrative Neuroscienceen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBrain - Anatomy & Histology - Physiologyen_US
dc.subject.meshDisease Models, Animalen_US
dc.subject.meshImage Processing, Computer-Assisted - Methodsen_US
dc.subject.meshMagnetic Resonance Imaging - Methodsen_US
dc.subject.meshMagnetic Resonance Spectroscopy - Methodsen_US
dc.subject.meshMiceen_US
dc.subject.meshRatsen_US
dc.subject.meshRodentia - Anatomy & Histology - Physiologyen_US
dc.subject.meshVisual Pathways - Anatomy & Histology - Physiologyen_US
dc.titleIn vivo multiparametric magnetic resonance imaging and spectroscopy of rodent visual systemen_US
dc.typeArticleen_US
dc.identifier.emailWu, EX:ewu1@hkucc.hku.hken_US
dc.identifier.authorityWu, EX=rp00193en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1142/S0219635210002524en_US
dc.identifier.pmid21213415-
dc.identifier.scopuseid_2-s2.0-78650957838en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78650957838&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume9en_US
dc.identifier.issue4en_US
dc.identifier.spage477en_US
dc.identifier.epage508en_US
dc.identifier.isiWOS:000285840400007-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridChan, KC=34968940300en_US
dc.identifier.scopusauthoridCheung, MM=24333907800en_US
dc.identifier.scopusauthoridWu, EX=7202128034en_US

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