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Article: Metabolic changes in visual cortex of neonatal monocular enucleated rat: A proton magnetic resonance spectroscopy study

TitleMetabolic changes in visual cortex of neonatal monocular enucleated rat: A proton magnetic resonance spectroscopy study
Authors
Keywords1H MRS
NAA
Neonatal monocular enucleation
Rat
Taurine
Visual cortex
Issue Date2011
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/ijdevneu
Citation
International Journal Of Developmental Neuroscience, 2011, v. 29 n. 1, p. 25-30 How to Cite?
AbstractNeonatal monocular enucleation (ME) is often employed to study the developmental mechanisms underlying visual perception and the cross-modal changes in the central nervous system caused by early loss of the visual input. However, underlying biochemical or metabolic mechanisms that accompany the morphological, physiological and behavioral changes after ME are not fully understood. Male Sprague-Dawley rats (N=14) were prepared and divided into 2 groups. The enucleated group (N=8) underwent right ME (right eye removal) at postnatal day 10, while the normal group (N=6) was intact and served as a control. Three weeks after ME, single voxel proton magnetic resonance spectroscopy (1H MRS) was performed over the visual cortex of each hemisphere in all animals with a point-resolved spectroscopy (PRESS) sequence at 7T. The taurine (Tau) and N-acetylaspartate (NAA) levels were found to be significantly lower in the left visual cortex (contralateral to enucleated eye) for enucleated animals. Such metabolic changes measured in vivo likely reflected the cortical degeneration associated with the reduction of neurons, axon terminals and overall neuronal activity. This study also demonstrated that 1H MRS approach has the potential to characterize neonatal ME and other developmental neuroplasticity models noninvasively for the biochemical and metabolic processes involved. © 2010 ISDN.
Persistent Identifierhttp://hdl.handle.net/10722/155592
ISSN
2015 Impact Factor: 2.38
2015 SCImago Journal Rankings: 1.109
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChow, AMen_HK
dc.contributor.authorZhou, IYen_HK
dc.contributor.authorFan, SJen_HK
dc.contributor.authorChan, KWYen_HK
dc.contributor.authorChan, KCen_HK
dc.contributor.authorWu, EXen_HK
dc.date.accessioned2012-08-08T08:34:16Z-
dc.date.available2012-08-08T08:34:16Z-
dc.date.issued2011en_HK
dc.identifier.citationInternational Journal Of Developmental Neuroscience, 2011, v. 29 n. 1, p. 25-30en_HK
dc.identifier.issn0736-5748en_HK
dc.identifier.urihttp://hdl.handle.net/10722/155592-
dc.description.abstractNeonatal monocular enucleation (ME) is often employed to study the developmental mechanisms underlying visual perception and the cross-modal changes in the central nervous system caused by early loss of the visual input. However, underlying biochemical or metabolic mechanisms that accompany the morphological, physiological and behavioral changes after ME are not fully understood. Male Sprague-Dawley rats (N=14) were prepared and divided into 2 groups. The enucleated group (N=8) underwent right ME (right eye removal) at postnatal day 10, while the normal group (N=6) was intact and served as a control. Three weeks after ME, single voxel proton magnetic resonance spectroscopy (1H MRS) was performed over the visual cortex of each hemisphere in all animals with a point-resolved spectroscopy (PRESS) sequence at 7T. The taurine (Tau) and N-acetylaspartate (NAA) levels were found to be significantly lower in the left visual cortex (contralateral to enucleated eye) for enucleated animals. Such metabolic changes measured in vivo likely reflected the cortical degeneration associated with the reduction of neurons, axon terminals and overall neuronal activity. This study also demonstrated that 1H MRS approach has the potential to characterize neonatal ME and other developmental neuroplasticity models noninvasively for the biochemical and metabolic processes involved. © 2010 ISDN.en_HK
dc.languageengen_US
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/ijdevneuen_HK
dc.relation.ispartofInternational Journal of Developmental Neuroscienceen_HK
dc.subject1H MRSen_HK
dc.subjectNAAen_HK
dc.subjectNeonatal monocular enucleationen_HK
dc.subjectRaten_HK
dc.subjectTaurineen_HK
dc.subjectVisual cortexen_HK
dc.subject.meshAnimalsen_US
dc.subject.meshAnimals, Newbornen_US
dc.subject.meshAspartic Acid - Analogs & Derivatives - Metabolismen_US
dc.subject.meshEye Enucleationen_US
dc.subject.meshMagnetic Resonance Spectroscopy - Methodsen_US
dc.subject.meshMaleen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshTaurine - Metabolismen_US
dc.subject.meshVision, Monocular - Physiologyen_US
dc.subject.meshVisual Cortex - Metabolismen_US
dc.titleMetabolic changes in visual cortex of neonatal monocular enucleated rat: A proton magnetic resonance spectroscopy studyen_HK
dc.typeArticleen_HK
dc.identifier.emailZhou, IY: izhou@hku.hken_HK
dc.identifier.emailWu, EX: ewu1@hkucc.hku.hken_HK
dc.identifier.authorityZhou, IY=rp01739en_HK
dc.identifier.authorityWu, EX=rp00193en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.ijdevneu.2010.10.002en_HK
dc.identifier.pmid20950681-
dc.identifier.scopuseid_2-s2.0-78650173086en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78650173086&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume29en_HK
dc.identifier.issue1en_HK
dc.identifier.spage25en_HK
dc.identifier.epage30en_HK
dc.identifier.isiWOS:000286846500004-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridChow, AM=16174234200en_HK
dc.identifier.scopusauthoridZhou, IY=35424838500en_HK
dc.identifier.scopusauthoridFan, SJ=36514618100en_HK
dc.identifier.scopusauthoridChan, KWY=35763564900en_HK
dc.identifier.scopusauthoridChan, KC=34968940300en_HK
dc.identifier.scopusauthoridWu, EX=7202128034en_HK
dc.identifier.citeulike8041238-

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