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Article: Hippocampal neurochemistry is involved in the behavioural effects of neonatal maternal separation and their reversal by post-weaning environmental enrichment: A magnetic resonance study
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TitleHippocampal neurochemistry is involved in the behavioural effects of neonatal maternal separation and their reversal by post-weaning environmental enrichment: A magnetic resonance study
 
AuthorsHui, JJ3
Zhang, ZJ3
Liu, SS3
Xi, GJ3
Zhang, XR3
Teng, GJ3
Chan, KC2
Wu, EX2
Nie, BB4
Shan, BC4
Li, LJ1
Reynolds, GP5
 
Issue Date2011
 
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/bbr
 
CitationBehavioural Brain Research, 2011, v. 217 n. 1, p. 122-127 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.bbr.2010.10.014
 
AbstractExposure to early life stress results in behavioural changes, and these dysfunctions may persist throughout adulthood. In this study, we investigated whether hippocampus volume and neurochemical changes were involved in the appearance of these effects in the maternal separation (MS) animal model using the noninvasive techniques of structural magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS). Sprague-Dawley rats exposed to MS for 180. min from postnatal days (PND) 2-14 demonstrated decreased sucrose preference, increased immobility in the forced swimming test (FST), and impaired memory in the Morris water maze in adulthood. Environmental enrichment (EE) (PND 21-60) could ameliorate the effects of MS on sucrose preference and learning and memory but not on immobility in the FST. In addition, EE significantly increased N-acetylaspartate (NAA) of MS animals. However, we did not find an effect of MS or EE on hippocampal volume. These results indicate the involvement of hippocampal neurochemistry in the behavioural changes that result from early stressful life events and their modification by post-weaning EE. Thus changes in NAA, as a measure of neuronal integrity, appear to be a sensitive correlate of these behavioural effects. © 2010 Elsevier B.V.
 
ISSN0166-4328
2013 Impact Factor: 3.391
2013 SCImago Journal Rankings: 1.838
 
DOIhttp://dx.doi.org/10.1016/j.bbr.2010.10.014
 
ISI Accession Number IDWOS:000286539700018
Funding AgencyGrant Number
National Natural Science Foundation of China30770779
30825014
30830046
National Basic Research Program of China (973 Program)2007CB512308
2009CB918303
National Hi-Tech Research and Development Program of China (863 Program)2008AA02Z413
Funding Information:

This research was partly supported by National Natural Science Foundation of China (No. 30770779 and No. 30825014 to Zhijun Zhang; No. 30830046 to Lingjiang Li), National Basic Research Program of China (973 Program) (No. 2007CB512308 to Zhijun Zhang; No. 2009CB918303 to Lingjiang Li) and National Hi-Tech Research and Development Program of China (863 Program) (No. 2008AA02Z413 to Zhijun Zhang). The authors would like to express our thanks to the staff of the Institute of Molecular Radiology, Medical School of Southeast University, for their technical assistance.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorHui, JJ
 
dc.contributor.authorZhang, ZJ
 
dc.contributor.authorLiu, SS
 
dc.contributor.authorXi, GJ
 
dc.contributor.authorZhang, XR
 
dc.contributor.authorTeng, GJ
 
dc.contributor.authorChan, KC
 
dc.contributor.authorWu, EX
 
dc.contributor.authorNie, BB
 
dc.contributor.authorShan, BC
 
dc.contributor.authorLi, LJ
 
dc.contributor.authorReynolds, GP
 
dc.date.accessioned2012-08-08T08:34:15Z
 
dc.date.available2012-08-08T08:34:15Z
 
dc.date.issued2011
 
dc.description.abstractExposure to early life stress results in behavioural changes, and these dysfunctions may persist throughout adulthood. In this study, we investigated whether hippocampus volume and neurochemical changes were involved in the appearance of these effects in the maternal separation (MS) animal model using the noninvasive techniques of structural magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS). Sprague-Dawley rats exposed to MS for 180. min from postnatal days (PND) 2-14 demonstrated decreased sucrose preference, increased immobility in the forced swimming test (FST), and impaired memory in the Morris water maze in adulthood. Environmental enrichment (EE) (PND 21-60) could ameliorate the effects of MS on sucrose preference and learning and memory but not on immobility in the FST. In addition, EE significantly increased N-acetylaspartate (NAA) of MS animals. However, we did not find an effect of MS or EE on hippocampal volume. These results indicate the involvement of hippocampal neurochemistry in the behavioural changes that result from early stressful life events and their modification by post-weaning EE. Thus changes in NAA, as a measure of neuronal integrity, appear to be a sensitive correlate of these behavioural effects. © 2010 Elsevier B.V.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationBehavioural Brain Research, 2011, v. 217 n. 1, p. 122-127 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.bbr.2010.10.014
 
dc.identifier.citeulike8136969
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.bbr.2010.10.014
 
dc.identifier.epage127
 
dc.identifier.isiWOS:000286539700018
Funding AgencyGrant Number
National Natural Science Foundation of China30770779
30825014
30830046
National Basic Research Program of China (973 Program)2007CB512308
2009CB918303
National Hi-Tech Research and Development Program of China (863 Program)2008AA02Z413
Funding Information:

This research was partly supported by National Natural Science Foundation of China (No. 30770779 and No. 30825014 to Zhijun Zhang; No. 30830046 to Lingjiang Li), National Basic Research Program of China (973 Program) (No. 2007CB512308 to Zhijun Zhang; No. 2009CB918303 to Lingjiang Li) and National Hi-Tech Research and Development Program of China (863 Program) (No. 2008AA02Z413 to Zhijun Zhang). The authors would like to express our thanks to the staff of the Institute of Molecular Radiology, Medical School of Southeast University, for their technical assistance.

 
dc.identifier.issn0166-4328
2013 Impact Factor: 3.391
2013 SCImago Journal Rankings: 1.838
 
dc.identifier.issue1
 
dc.identifier.pmid20974193
 
dc.identifier.scopuseid_2-s2.0-78149312765
 
dc.identifier.spage122
 
dc.identifier.urihttp://hdl.handle.net/10722/155589
 
dc.identifier.volume217
 
dc.languageeng
 
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/bbr
 
dc.publisher.placeNetherlands
 
dc.relation.ispartofBehavioural Brain Research
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAnimals
 
dc.subject.meshAspartic Acid - Analogs & Derivatives - Metabolism
 
dc.subject.meshAtrophy - Psychology
 
dc.subject.meshChoice Behavior - Physiology
 
dc.subject.meshEnvironment
 
dc.subject.meshFemale
 
dc.subject.meshHippocampus - Metabolism - Pathology
 
dc.subject.meshMagnetic Resonance Imaging - Methods
 
dc.subject.meshMagnetic Resonance Spectroscopy - Methods
 
dc.subject.meshMale
 
dc.subject.meshMaternal Deprivation
 
dc.subject.meshMaze Learning - Physiology
 
dc.subject.meshRats
 
dc.subject.meshRats, Sprague-Dawley
 
dc.subject.meshStress, Psychological - Metabolism - Physiopathology - Psychology
 
dc.subject.meshSwimming
 
dc.titleHippocampal neurochemistry is involved in the behavioural effects of neonatal maternal separation and their reversal by post-weaning environmental enrichment: A magnetic resonance study
 
dc.typeArticle
 
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Author Affiliations
  1. Second Xiangya Hospital of Central-South University
  2. The University of Hong Kong
  3. Southeast University
  4. Institute of High Energy Physics Chinese Academy of Science
  5. Sheffield Hallam University