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Article: Hippocampal neurochemistry is involved in the behavioural effects of neonatal maternal separation and their reversal by post-weaning environmental enrichment: A magnetic resonance study

TitleHippocampal neurochemistry is involved in the behavioural effects of neonatal maternal separation and their reversal by post-weaning environmental enrichment: A magnetic resonance study
Authors
Issue Date2011
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/bbr
Citation
Behavioural Brain Research, 2011, v. 217 n. 1, p. 122-127 How to Cite?
Abstract
Exposure to early life stress results in behavioural changes, and these dysfunctions may persist throughout adulthood. In this study, we investigated whether hippocampus volume and neurochemical changes were involved in the appearance of these effects in the maternal separation (MS) animal model using the noninvasive techniques of structural magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS). Sprague-Dawley rats exposed to MS for 180. min from postnatal days (PND) 2-14 demonstrated decreased sucrose preference, increased immobility in the forced swimming test (FST), and impaired memory in the Morris water maze in adulthood. Environmental enrichment (EE) (PND 21-60) could ameliorate the effects of MS on sucrose preference and learning and memory but not on immobility in the FST. In addition, EE significantly increased N-acetylaspartate (NAA) of MS animals. However, we did not find an effect of MS or EE on hippocampal volume. These results indicate the involvement of hippocampal neurochemistry in the behavioural changes that result from early stressful life events and their modification by post-weaning EE. Thus changes in NAA, as a measure of neuronal integrity, appear to be a sensitive correlate of these behavioural effects. © 2010 Elsevier B.V.
Persistent Identifierhttp://hdl.handle.net/10722/155589
ISSN
2013 Impact Factor: 3.391
2013 SCImago Journal Rankings: 1.838
ISI Accession Number ID
Funding AgencyGrant Number
National Natural Science Foundation of China30770779
30825014
30830046
National Basic Research Program of China (973 Program)2007CB512308
2009CB918303
National Hi-Tech Research and Development Program of China (863 Program)2008AA02Z413
Funding Information:

This research was partly supported by National Natural Science Foundation of China (No. 30770779 and No. 30825014 to Zhijun Zhang; No. 30830046 to Lingjiang Li), National Basic Research Program of China (973 Program) (No. 2007CB512308 to Zhijun Zhang; No. 2009CB918303 to Lingjiang Li) and National Hi-Tech Research and Development Program of China (863 Program) (No. 2008AA02Z413 to Zhijun Zhang). The authors would like to express our thanks to the staff of the Institute of Molecular Radiology, Medical School of Southeast University, for their technical assistance.

References

 

Author Affiliations
  1. Second Xiangya Hospital of Central-South University
  2. The University of Hong Kong
  3. Southeast University
  4. Institute of High Energy Physics Chinese Academy of Science
  5. Sheffield Hallam University
DC FieldValueLanguage
dc.contributor.authorHui, JJen_US
dc.contributor.authorZhang, ZJen_US
dc.contributor.authorLiu, SSen_US
dc.contributor.authorXi, GJen_US
dc.contributor.authorZhang, XRen_US
dc.contributor.authorTeng, GJen_US
dc.contributor.authorChan, KCen_US
dc.contributor.authorWu, EXen_US
dc.contributor.authorNie, BBen_US
dc.contributor.authorShan, BCen_US
dc.contributor.authorLi, LJen_US
dc.contributor.authorReynolds, GPen_US
dc.date.accessioned2012-08-08T08:34:15Z-
dc.date.available2012-08-08T08:34:15Z-
dc.date.issued2011en_US
dc.identifier.citationBehavioural Brain Research, 2011, v. 217 n. 1, p. 122-127en_US
dc.identifier.issn0166-4328en_US
dc.identifier.urihttp://hdl.handle.net/10722/155589-
dc.description.abstractExposure to early life stress results in behavioural changes, and these dysfunctions may persist throughout adulthood. In this study, we investigated whether hippocampus volume and neurochemical changes were involved in the appearance of these effects in the maternal separation (MS) animal model using the noninvasive techniques of structural magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS). Sprague-Dawley rats exposed to MS for 180. min from postnatal days (PND) 2-14 demonstrated decreased sucrose preference, increased immobility in the forced swimming test (FST), and impaired memory in the Morris water maze in adulthood. Environmental enrichment (EE) (PND 21-60) could ameliorate the effects of MS on sucrose preference and learning and memory but not on immobility in the FST. In addition, EE significantly increased N-acetylaspartate (NAA) of MS animals. However, we did not find an effect of MS or EE on hippocampal volume. These results indicate the involvement of hippocampal neurochemistry in the behavioural changes that result from early stressful life events and their modification by post-weaning EE. Thus changes in NAA, as a measure of neuronal integrity, appear to be a sensitive correlate of these behavioural effects. © 2010 Elsevier B.V.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/bbren_US
dc.relation.ispartofBehavioural Brain Researchen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAspartic Acid - Analogs & Derivatives - Metabolismen_US
dc.subject.meshAtrophy - Psychologyen_US
dc.subject.meshChoice Behavior - Physiologyen_US
dc.subject.meshEnvironmenten_US
dc.subject.meshFemaleen_US
dc.subject.meshHippocampus - Metabolism - Pathologyen_US
dc.subject.meshMagnetic Resonance Imaging - Methodsen_US
dc.subject.meshMagnetic Resonance Spectroscopy - Methodsen_US
dc.subject.meshMaleen_US
dc.subject.meshMaternal Deprivationen_US
dc.subject.meshMaze Learning - Physiologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshStress, Psychological - Metabolism - Physiopathology - Psychologyen_US
dc.subject.meshSwimmingen_US
dc.titleHippocampal neurochemistry is involved in the behavioural effects of neonatal maternal separation and their reversal by post-weaning environmental enrichment: A magnetic resonance studyen_US
dc.typeArticleen_US
dc.identifier.emailWu, EX:ewu1@hkucc.hku.hken_US
dc.identifier.authorityWu, EX=rp00193en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.bbr.2010.10.014en_US
dc.identifier.pmid20974193en_US
dc.identifier.scopuseid_2-s2.0-78149312765en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78149312765&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume217en_US
dc.identifier.issue1en_US
dc.identifier.spage122en_US
dc.identifier.epage127en_US
dc.identifier.isiWOS:000286539700018-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridHui, JJ=36573527000en_US
dc.identifier.scopusauthoridZhang, ZJ=15081680700en_US
dc.identifier.scopusauthoridLiu, SS=37091213900en_US
dc.identifier.scopusauthoridXi, GJ=23669525900en_US
dc.identifier.scopusauthoridZhang, XR=36718366100en_US
dc.identifier.scopusauthoridTeng, GJ=7004411906en_US
dc.identifier.scopusauthoridChan, KC=34968940300en_US
dc.identifier.scopusauthoridWu, EX=7202128034en_US
dc.identifier.scopusauthoridNie, BB=28267940200en_US
dc.identifier.scopusauthoridShan, BC=7006926463en_US
dc.identifier.scopusauthoridLi, LJ=23995582200en_US
dc.identifier.scopusauthoridReynolds, GP=7201487920en_US
dc.identifier.citeulike8136969-

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