Article: Hippocampal neurochemistry is involved in the behavioural effects of neonatal maternal separation and their reversal by post-weaning environmental enrichment: A magnetic resonance study
| Title | Hippocampal neurochemistry is involved in the behavioural effects of neonatal maternal separation and their reversal by post-weaning environmental enrichment: A magnetic resonance study | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Authors | Hui, JJ3 Zhang, ZJ3 Liu, SS3 Xi, GJ3 Zhang, XR3 Teng, GJ3 Chan, KC2 Wu, EX2 Nie, BB4 Shan, BC4 Li, LJ1 Reynolds, GP5 | ||||||||
| Issue Date | 2011 | ||||||||
| Publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/bbr | ||||||||
| Citation | Behavioural Brain Research, 2011, v. 217 n. 1, p. 122-127 [How to Cite?] DOI: http://dx.doi.org/10.1016/j.bbr.2010.10.014 | ||||||||
| Abstract | Exposure to early life stress results in behavioural changes, and these dysfunctions may persist throughout adulthood. In this study, we investigated whether hippocampus volume and neurochemical changes were involved in the appearance of these effects in the maternal separation (MS) animal model using the noninvasive techniques of structural magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS). Sprague-Dawley rats exposed to MS for 180. min from postnatal days (PND) 2-14 demonstrated decreased sucrose preference, increased immobility in the forced swimming test (FST), and impaired memory in the Morris water maze in adulthood. Environmental enrichment (EE) (PND 21-60) could ameliorate the effects of MS on sucrose preference and learning and memory but not on immobility in the FST. In addition, EE significantly increased N-acetylaspartate (NAA) of MS animals. However, we did not find an effect of MS or EE on hippocampal volume. These results indicate the involvement of hippocampal neurochemistry in the behavioural changes that result from early stressful life events and their modification by post-weaning EE. Thus changes in NAA, as a measure of neuronal integrity, appear to be a sensitive correlate of these behavioural effects. © 2010 Elsevier B.V. | ||||||||
| ISSN | 0166-4328 2011 Impact Factor: 3.417 2011 SCImago Journal Rankings: 0.236 | ||||||||
| DOI | http://dx.doi.org/10.1016/j.bbr.2010.10.014 | ||||||||
| ISI Accession Number ID | WOS:000286539700018
Funding Information: This research was partly supported by National Natural Science Foundation of China (No. 30770779 and No. 30825014 to Zhijun Zhang; No. 30830046 to Lingjiang Li), National Basic Research Program of China (973 Program) (No. 2007CB512308 to Zhijun Zhang; No. 2009CB918303 to Lingjiang Li) and National Hi-Tech Research and Development Program of China (863 Program) (No. 2008AA02Z413 to Zhijun Zhang). The authors would like to express our thanks to the staff of the Institute of Molecular Radiology, Medical School of Southeast University, for their technical assistance. | ||||||||
| References | References in Scopus |
| dc.contributor.author | Hui, JJ | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| dc.contributor.author | Zhang, ZJ | ||||||||
| dc.contributor.author | Liu, SS | ||||||||
| dc.contributor.author | Xi, GJ | ||||||||
| dc.contributor.author | Zhang, XR | ||||||||
| dc.contributor.author | Teng, GJ | ||||||||
| dc.contributor.author | Chan, KC | ||||||||
| dc.contributor.author | Wu, EX | ||||||||
| dc.contributor.author | Nie, BB | ||||||||
| dc.contributor.author | Shan, BC | ||||||||
| dc.contributor.author | Li, LJ | ||||||||
| dc.contributor.author | Reynolds, GP | ||||||||
| dc.date.accessioned | 2012-08-08T08:34:15Z | ||||||||
| dc.date.available | 2012-08-08T08:34:15Z | ||||||||
| dc.date.issued | 2011 | ||||||||
| dc.description.abstract | Exposure to early life stress results in behavioural changes, and these dysfunctions may persist throughout adulthood. In this study, we investigated whether hippocampus volume and neurochemical changes were involved in the appearance of these effects in the maternal separation (MS) animal model using the noninvasive techniques of structural magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS). Sprague-Dawley rats exposed to MS for 180. min from postnatal days (PND) 2-14 demonstrated decreased sucrose preference, increased immobility in the forced swimming test (FST), and impaired memory in the Morris water maze in adulthood. Environmental enrichment (EE) (PND 21-60) could ameliorate the effects of MS on sucrose preference and learning and memory but not on immobility in the FST. In addition, EE significantly increased N-acetylaspartate (NAA) of MS animals. However, we did not find an effect of MS or EE on hippocampal volume. These results indicate the involvement of hippocampal neurochemistry in the behavioural changes that result from early stressful life events and their modification by post-weaning EE. Thus changes in NAA, as a measure of neuronal integrity, appear to be a sensitive correlate of these behavioural effects. © 2010 Elsevier B.V. | ||||||||
| dc.description.nature | Link_to_subscribed_fulltext | ||||||||
| dc.identifier.citation | Behavioural Brain Research, 2011, v. 217 n. 1, p. 122-127 [How to Cite?] DOI: http://dx.doi.org/10.1016/j.bbr.2010.10.014 | ||||||||
| dc.identifier.citeulike | 8136969 | ||||||||
| dc.identifier.doi | http://dx.doi.org/10.1016/j.bbr.2010.10.014 | ||||||||
| dc.identifier.epage | 127 | ||||||||
| dc.identifier.isi | WOS:000286539700018
Funding Information: This research was partly supported by National Natural Science Foundation of China (No. 30770779 and No. 30825014 to Zhijun Zhang; No. 30830046 to Lingjiang Li), National Basic Research Program of China (973 Program) (No. 2007CB512308 to Zhijun Zhang; No. 2009CB918303 to Lingjiang Li) and National Hi-Tech Research and Development Program of China (863 Program) (No. 2008AA02Z413 to Zhijun Zhang). The authors would like to express our thanks to the staff of the Institute of Molecular Radiology, Medical School of Southeast University, for their technical assistance. | ||||||||
| dc.identifier.issn | 0166-4328 2011 Impact Factor: 3.417 2011 SCImago Journal Rankings: 0.236 | ||||||||
| dc.identifier.issue | 1 | ||||||||
| dc.identifier.pmid | 20974193 | ||||||||
| dc.identifier.scopus | eid_2-s2.0-78149312765 | ||||||||
| dc.identifier.spage | 122 | ||||||||
| dc.identifier.uri | http://hdl.handle.net/10722/155589 | ||||||||
| dc.identifier.volume | 217 | ||||||||
| dc.language | eng | ||||||||
| dc.publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/bbr | ||||||||
| dc.publisher.place | Netherlands | ||||||||
| dc.relation.ispartof | Behavioural Brain Research | ||||||||
| dc.relation.references | References in Scopus | ||||||||
| dc.subject.mesh | Animals | ||||||||
| dc.subject.mesh | Aspartic Acid - Analogs & Derivatives - Metabolism | ||||||||
| dc.subject.mesh | Atrophy - Psychology | ||||||||
| dc.subject.mesh | Choice Behavior - Physiology | ||||||||
| dc.subject.mesh | Environment | ||||||||
| dc.subject.mesh | Female | ||||||||
| dc.subject.mesh | Hippocampus - Metabolism - Pathology | ||||||||
| dc.subject.mesh | Magnetic Resonance Imaging - Methods | ||||||||
| dc.subject.mesh | Magnetic Resonance Spectroscopy - Methods | ||||||||
| dc.subject.mesh | Male | ||||||||
| dc.subject.mesh | Maternal Deprivation | ||||||||
| dc.subject.mesh | Maze Learning - Physiology | ||||||||
| dc.subject.mesh | Rats | ||||||||
| dc.subject.mesh | Rats, Sprague-Dawley | ||||||||
| dc.subject.mesh | Stress, Psychological - Metabolism - Physiopathology - Psychology | ||||||||
| dc.subject.mesh | Swimming | ||||||||
| dc.title | Hippocampal neurochemistry is involved in the behavioural effects of neonatal maternal separation and their reversal by post-weaning environmental enrichment: A magnetic resonance study | ||||||||
| dc.type | Article |
Author Affiliations
- Second Xiangya Hospital of Central-South University
- The University of Hong Kong
- Southeast University
- Institute of High Energy Physics Chinese Academy of Science
- Sheffield Hallam University