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Article: Long-term effects of B-type natriuretic peptide infusion after acute myocardial infarction in a rat model

TitleLong-term effects of B-type natriuretic peptide infusion after acute myocardial infarction in a rat model
Authors
Issue Date2010
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/
Citation
Journal Of Cardiovascular Pharmacology, 2010, v. 55 n. 1, p. 14-20 How to Cite?
AbstractINTRODUCTION:: The effects of exogenous B-type natriuretic peptide (BNP) on postmyocardial infarction (MI) are not known. We tested the hypothesis that in vivo infusion of BNP would improve cardiac function and affect left ventricular (LV) remodeling in an experimental model of MI. METHODS:: MI was induced by coronary ligation in rats and confirmed by echocardiography. 19 rats were randomized to 1 of 3 groups: sham (n = 7), MI + saline (n = 5), MI + BNP (400 ng•kg•minute) (n = 7). Infusions were delivered for 7 days via venous catheters tunneled to an infusion pump. Rats were followed for 8 weeks. Echocardiography, hemodynamics, histology, and in vivo and ex vivo pressure-volume relationships were examined. RESULTS:: LV systolic pressure, LV dP/dtmax, and infarct size improved with BNP treatment versus control MI group (132 ± 4 vs. 110 ± 2 mm Hg, 8097 ± 317 vs. 5816 ± 378 mm Hg/s, 19.3% ± 1.6% vs. 23.3% ± 1.9%, respectively; all P < 0.05). Ex vivo end-diastolic pressure-volume relationship demonstrated reduced diastolic dysfunction after BNP therapy (P < 0.05 vs. control MI). Serum BNP levels confirmed delivery of BNP. CONCLUSIONS:: We demonstrate beneficial effects on LV function and decreased LV remodeling with BNP infusion in an experimental model of acute MI. Copyright © 2010 by Lippincott Williams & Wilkins.
Persistent Identifierhttp://hdl.handle.net/10722/155555
ISSN
2015 Impact Factor: 2.462
2015 SCImago Journal Rankings: 0.962
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorGeorge, Ien_US
dc.contributor.authorXydas, Sen_US
dc.contributor.authorKlotz, Sen_US
dc.contributor.authorHay, Ien_US
dc.contributor.authorNg, Cen_US
dc.contributor.authorChang, Jen_US
dc.contributor.authorXu, Ken_US
dc.contributor.authorLi, Zen_US
dc.contributor.authorProtter, AAen_US
dc.contributor.authorWu, EXen_US
dc.contributor.authorOz, MCen_US
dc.contributor.authorWang, Jen_US
dc.date.accessioned2012-08-08T08:34:05Z-
dc.date.available2012-08-08T08:34:05Z-
dc.date.issued2010en_US
dc.identifier.citationJournal Of Cardiovascular Pharmacology, 2010, v. 55 n. 1, p. 14-20en_US
dc.identifier.issn0160-2446en_US
dc.identifier.urihttp://hdl.handle.net/10722/155555-
dc.description.abstractINTRODUCTION:: The effects of exogenous B-type natriuretic peptide (BNP) on postmyocardial infarction (MI) are not known. We tested the hypothesis that in vivo infusion of BNP would improve cardiac function and affect left ventricular (LV) remodeling in an experimental model of MI. METHODS:: MI was induced by coronary ligation in rats and confirmed by echocardiography. 19 rats were randomized to 1 of 3 groups: sham (n = 7), MI + saline (n = 5), MI + BNP (400 ng•kg•minute) (n = 7). Infusions were delivered for 7 days via venous catheters tunneled to an infusion pump. Rats were followed for 8 weeks. Echocardiography, hemodynamics, histology, and in vivo and ex vivo pressure-volume relationships were examined. RESULTS:: LV systolic pressure, LV dP/dtmax, and infarct size improved with BNP treatment versus control MI group (132 ± 4 vs. 110 ± 2 mm Hg, 8097 ± 317 vs. 5816 ± 378 mm Hg/s, 19.3% ± 1.6% vs. 23.3% ± 1.9%, respectively; all P < 0.05). Ex vivo end-diastolic pressure-volume relationship demonstrated reduced diastolic dysfunction after BNP therapy (P < 0.05 vs. control MI). Serum BNP levels confirmed delivery of BNP. CONCLUSIONS:: We demonstrate beneficial effects on LV function and decreased LV remodeling with BNP infusion in an experimental model of acute MI. Copyright © 2010 by Lippincott Williams & Wilkins.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/en_US
dc.relation.ispartofJournal of Cardiovascular Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshDisease Models, Animalen_US
dc.subject.meshEchocardiographyen_US
dc.subject.meshMyocardial Infarction - Drug Therapy - Physiopathologyen_US
dc.subject.meshNatriuretic Agents - Administration & Dosage - Pharmacokinetics - Pharmacologyen_US
dc.subject.meshNatriuretic Peptide, Brain - Administration & Dosage - Pharmacokinetics - Pharmacologyen_US
dc.subject.meshRandom Allocationen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshVentricular Function, Left - Drug Effectsen_US
dc.subject.meshVentricular Remodeling - Drug Effectsen_US
dc.titleLong-term effects of B-type natriuretic peptide infusion after acute myocardial infarction in a rat modelen_US
dc.typeArticleen_US
dc.identifier.emailWu, EX:ewu1@hkucc.hku.hken_US
dc.identifier.authorityWu, EX=rp00193en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1097/FJC.0b013e3181c5e743en_US
dc.identifier.pmid19858735-
dc.identifier.scopuseid_2-s2.0-75749130708en_US
dc.identifier.hkuros177191-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-75749130708&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume55en_US
dc.identifier.issue1en_US
dc.identifier.spage14en_US
dc.identifier.epage20en_US
dc.identifier.isiWOS:000274172000003-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridGeorge, I=12787442300en_US
dc.identifier.scopusauthoridXydas, S=6507448586en_US
dc.identifier.scopusauthoridKlotz, S=9844521200en_US
dc.identifier.scopusauthoridHay, I=7101789694en_US
dc.identifier.scopusauthoridNg, C=14520703400en_US
dc.identifier.scopusauthoridChang, J=13002880300en_US
dc.identifier.scopusauthoridXu, K=37068180800en_US
dc.identifier.scopusauthoridLi, Z=9247928600en_US
dc.identifier.scopusauthoridProtter, AA=7003806029en_US
dc.identifier.scopusauthoridWu, EX=7202128034en_US
dc.identifier.scopusauthoridOz, MC=7102364376en_US
dc.identifier.scopusauthoridWang, J=8061150000en_US

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