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Article: Hyperphosphorylation and accumulation of neurofilament proteins in transgenic mice with alzheimer presenilin 1 mutation

TitleHyperphosphorylation and accumulation of neurofilament proteins in transgenic mice with alzheimer presenilin 1 mutation
Authors
Yang, XYang, YLuo, YLi, GWang, JYang, ES
KeywordsAlzheimer's disease
Hyperphosphorylation
JNK
Neurofilaments
Presenilin-1
Issue Date2009
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0272-4340
Citation
Cellular And Molecular Neurobiology, 2009, v. 29 n. 4, p. 497-501 How to Cite?
DOI: http://dx.doi.org/10.1007/s10571-008-9341-7
AbstractNeurofilaments (NFs) are hyperphosphorylated and accumulate in Alzheimer's disease (AD) brains. In this study, employing the transgenic mouse model, we explored the effect of presenilin 1 (PS-1) mutation on the phosphorylation and distribution of NFs. Western blot analysis showed that there was a significant increase in the phosphorylation of NF-H and NF-M subunits with a concomitant increase in phosphorylated c-Jun N-terminal protein kinase 1/2 (JNK1/2) mitogen-activated protein kinase (MAPK) in hippocampus of PS-1 transgenic mice compared to that of wild-type littermates. Immunohistochemical analysis revealed that phosphorylated NFs accumulated throughout the hippocampal neurons of the transgenic mice. These findings suggest that PS-1 mutation may induce hyperphosphorylation and accumulation of NFs via a JNK1/2-involved mechanism. © 2009 Springer Science+Business Media, LLC.
Persistent Identifierhttp://hdl.handle.net/10722/155527
ISSN
0272-4340
2023 Impact Factor: 3.6
2023 SCImago Journal Rankings: 1.118
ISI Accession Number ID
WOS:000266921200008
Funding AgencyGrant Number
National Natural Science Foundation of China30700277
Funding Information:

This study was supported by a grant from National Natural Science Foundation of China (30700277).

References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorYang, Xen_US
dc.contributor.authorYang, Yen_US
dc.contributor.authorLuo, Yen_US
dc.contributor.authorLi, Gen_US
dc.contributor.authorWang, Jen_US
dc.contributor.authorYang, ESen_US
dc.date.accessioned2012-08-08T08:33:56Z-
dc.date.available2012-08-08T08:33:56Z-
dc.date.issued2009en_US
dc.identifier.citationCellular And Molecular Neurobiology, 2009, v. 29 n. 4, p. 497-501en_US
dc.identifier.issn0272-4340en_US
dc.identifier.urihttp://hdl.handle.net/10722/155527-
dc.description.abstractNeurofilaments (NFs) are hyperphosphorylated and accumulate in Alzheimer's disease (AD) brains. In this study, employing the transgenic mouse model, we explored the effect of presenilin 1 (PS-1) mutation on the phosphorylation and distribution of NFs. Western blot analysis showed that there was a significant increase in the phosphorylation of NF-H and NF-M subunits with a concomitant increase in phosphorylated c-Jun N-terminal protein kinase 1/2 (JNK1/2) mitogen-activated protein kinase (MAPK) in hippocampus of PS-1 transgenic mice compared to that of wild-type littermates. Immunohistochemical analysis revealed that phosphorylated NFs accumulated throughout the hippocampal neurons of the transgenic mice. These findings suggest that PS-1 mutation may induce hyperphosphorylation and accumulation of NFs via a JNK1/2-involved mechanism. © 2009 Springer Science+Business Media, LLC.en_US
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0272-4340en_US
dc.relation.ispartofCellular and Molecular Neurobiologyen_US
dc.subjectAlzheimer's disease-
dc.subjectHyperphosphorylation-
dc.subjectJNK-
dc.subjectNeurofilaments-
dc.subjectPresenilin-1-
dc.subject.meshAlzheimer Disease - Genetics - Metabolismen_US
dc.subject.meshAnimalsen_US
dc.subject.meshDisease Models, Animalen_US
dc.subject.meshExtracellular Signal-Regulated Map Kinases - Metabolismen_US
dc.subject.meshHippocampus - Cytology - Metabolismen_US
dc.subject.meshJnk Mitogen-Activated Protein Kinases - Metabolismen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Transgenicen_US
dc.subject.meshNeurofilament Proteins - Genetics - Metabolismen_US
dc.subject.meshPhosphorylationen_US
dc.subject.meshPresenilin-1 - Genetics - Metabolismen_US
dc.titleHyperphosphorylation and accumulation of neurofilament proteins in transgenic mice with alzheimer presenilin 1 mutationen_US
dc.typeArticleen_US
dc.identifier.emailYang, ES:esyang@hkueee.hku.hken_US
dc.identifier.authorityYang, ES=rp00199en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s10571-008-9341-7en_US
dc.identifier.pmid19137424-
dc.identifier.scopuseid_2-s2.0-67449132628en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-67449132628&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume29en_US
dc.identifier.issue4en_US
dc.identifier.spage497en_US
dc.identifier.epage501en_US
dc.identifier.isiWOS:000266921200008-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridYang, X=23007172600en_US
dc.identifier.scopusauthoridYang, Y=34769311500en_US
dc.identifier.scopusauthoridLuo, Y=24725002200en_US
dc.identifier.scopusauthoridLi, G=35767974200en_US
dc.identifier.scopusauthoridWang, J=7701331129en_US
dc.identifier.scopusauthoridYang, ES=7202021229en_US
dc.identifier.citeulike3896155-
dc.identifier.issnl0272-4340-

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