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Article: In vivo MRI quantification of individual muscle and organ volumes for assessment of anabolic steroid growth effects

TitleIn vivo MRI quantification of individual muscle and organ volumes for assessment of anabolic steroid growth effects
Authors
Issue Date2008
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/steroids
Citation
Steroids, 2008, v. 73 n. 4, p. 430-440 How to Cite?
AbstractThis study aimed to develop a quantitative and in vivo magnetic resonance imaging (MRI) approach to investigate the muscle growth effects of anabolic steroids. A protocol of MRI acquisition on a standard clinical 1.5 T scanner and quantitative image analysis was established and employed to measure the individual muscle and organ volumes in the intact and castrated guinea pigs undergoing a 16-week treatment protocol by two well-documented anabolic steroids, testosterone and nandrolone, via implanted silastic capsules. High correlations between the in vivo MRI and postmortem dissection measurements were observed for shoulder muscle complex (R = 0.86), masseter (R = 0.79), temporalis (R = 0.95), neck muscle complex (R = 0.58), prostate gland and seminal vesicles (R = 0.98), and testis (R = 0.96). Furthermore, the longitudinal MRI measurements yielded adequate sensitivity to detect the restoration of growth to or towards normal in castrated guinea pigs by replacing circulating steroid levels to physiological or slightly higher levels, as expected. These results demonstrated that quantitative MRI using a standard clinical scanner provides accurate and sensitive measurement of individual muscles and organs, and this in vivo MRI protocol in conjunction with the castrated guinea pig model constitutes an effective platform to investigate the longitudinal and cross-sectional growth effects of other potential anabolic steroids. The quantitative MRI protocol developed can also be readily adapted for human studies on most clinical MRI scanner to investigate the anabolic steroid growth effects, or monitor the changes in individual muscle and organ volume and geometry following injury, strength training, neuromuscular disorders, and pharmacological or surgical interventions. © 2008.
Persistent Identifierhttp://hdl.handle.net/10722/155437
ISSN
2015 Impact Factor: 2.513
2015 SCImago Journal Rankings: 0.876
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWu, EXen_US
dc.contributor.authorTang, Hen_US
dc.contributor.authorTong, Cen_US
dc.contributor.authorHeymsfield, SBen_US
dc.contributor.authorVasselli, JRen_US
dc.date.accessioned2012-08-08T08:33:29Z-
dc.date.available2012-08-08T08:33:29Z-
dc.date.issued2008en_US
dc.identifier.citationSteroids, 2008, v. 73 n. 4, p. 430-440en_US
dc.identifier.issn0039-128Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/155437-
dc.description.abstractThis study aimed to develop a quantitative and in vivo magnetic resonance imaging (MRI) approach to investigate the muscle growth effects of anabolic steroids. A protocol of MRI acquisition on a standard clinical 1.5 T scanner and quantitative image analysis was established and employed to measure the individual muscle and organ volumes in the intact and castrated guinea pigs undergoing a 16-week treatment protocol by two well-documented anabolic steroids, testosterone and nandrolone, via implanted silastic capsules. High correlations between the in vivo MRI and postmortem dissection measurements were observed for shoulder muscle complex (R = 0.86), masseter (R = 0.79), temporalis (R = 0.95), neck muscle complex (R = 0.58), prostate gland and seminal vesicles (R = 0.98), and testis (R = 0.96). Furthermore, the longitudinal MRI measurements yielded adequate sensitivity to detect the restoration of growth to or towards normal in castrated guinea pigs by replacing circulating steroid levels to physiological or slightly higher levels, as expected. These results demonstrated that quantitative MRI using a standard clinical scanner provides accurate and sensitive measurement of individual muscles and organs, and this in vivo MRI protocol in conjunction with the castrated guinea pig model constitutes an effective platform to investigate the longitudinal and cross-sectional growth effects of other potential anabolic steroids. The quantitative MRI protocol developed can also be readily adapted for human studies on most clinical MRI scanner to investigate the anabolic steroid growth effects, or monitor the changes in individual muscle and organ volume and geometry following injury, strength training, neuromuscular disorders, and pharmacological or surgical interventions. © 2008.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/steroidsen_US
dc.relation.ispartofSteroidsen_US
dc.subject.meshAnabolic Agents - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshMagnetic Resonance Imaging - Methodsen_US
dc.subject.meshMaleen_US
dc.subject.meshMuscles - Anatomy & Histology - Drug Effectsen_US
dc.subject.meshNandrolone - Pharmacologyen_US
dc.subject.meshOrgan Size - Drug Effectsen_US
dc.subject.meshSteroids - Pharmacologyen_US
dc.subject.meshSwineen_US
dc.subject.meshTestosterone - Pharmacologyen_US
dc.titleIn vivo MRI quantification of individual muscle and organ volumes for assessment of anabolic steroid growth effectsen_US
dc.typeArticleen_US
dc.identifier.emailWu, EX:ewu1@hkucc.hku.hken_US
dc.identifier.authorityWu, EX=rp00193en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.steroids.2007.12.011en_US
dc.identifier.pmid18241900-
dc.identifier.scopuseid_2-s2.0-39449101839en_US
dc.identifier.hkuros141493-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-39449101839&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume73en_US
dc.identifier.issue4en_US
dc.identifier.spage430en_US
dc.identifier.epage440en_US
dc.identifier.isiWOS:000254722700005-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridWu, EX=7202128034en_US
dc.identifier.scopusauthoridTang, H=36827331000en_US
dc.identifier.scopusauthoridTong, C=35796514400en_US
dc.identifier.scopusauthoridHeymsfield, SB=36038154600en_US
dc.identifier.scopusauthoridVasselli, JR=7003912429en_US

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