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Article: Detection of cortical gray matter lesion in the late phase of mild hypoxic-ischemic injury by manganese-enhanced MRI

TitleDetection of cortical gray matter lesion in the late phase of mild hypoxic-ischemic injury by manganese-enhanced MRI
Authors
Issue Date2008
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimg
Citation
Neuroimage, 2008, v. 39 n. 2, p. 669-679 How to Cite?
AbstractNoncystic periventricular leukomalacia (PVL) in premature infants is becoming a predominant lesion form. However, detection of the gray matter (GM) lesions involved in this disease, which closely relate to the later cognitive and behavioral deficits, is challenging because of their subtle and transient nature observed by conventional MRI. This study evaluated manganese-enhanced MRI (MEMRI) for detecting such GM lesions in 7-day-old rats with mild hypoxic-ischemic (H-I) insult, a characteristic model of noncystic PVL. Group 1 (n = 6) and Group 2 (n = 8) were administered intraperitoneally with MnCl2 at hour 3 and day 7 after H-I insult, respectively. Control Group (n = 6) received no MnCl2. T1-, T2- and diffusion-weighted imaging (T1WI, T2WI and DWI, respectively) was performed. Animals were sacrificed for H&E staining, and immunohistochemical staining for glutamine synthetase (GS) and Mn-superoxide dismutase (Mn-SOD), which are two Mn-binding enzymes against glutamate toxicity and oxidative stress respectively in neurodegeneration. In Control Group, MRI appearance of H-I lesions normalized by day 7 after H-I insult. In Group 1, MEMRI provided the enhanced and prolonged GM lesion detection from day 3 up to day 21. In Group 2, similar Mn enhancement was observed, enabling day 8 detection of GM lesions that were invisible before Mn injection at day 7. These in vivo Mn-induced GM lesion enhancements were found to correlate with increased immunoactivities of GS and Mn-SOD. These findings suggest the potential utility of MEMRI in detecting the GM lesions that are otherwise undetectable using the conventional MRI techniques in late phase of mild H-I injury. © 2007.
Persistent Identifierhttp://hdl.handle.net/10722/155398
ISSN
2015 Impact Factor: 5.463
2015 SCImago Journal Rankings: 4.464
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYang, Jen_US
dc.contributor.authorWu, EXen_US
dc.date.accessioned2012-08-08T08:33:17Z-
dc.date.available2012-08-08T08:33:17Z-
dc.date.issued2008en_US
dc.identifier.citationNeuroimage, 2008, v. 39 n. 2, p. 669-679en_US
dc.identifier.issn1053-8119en_US
dc.identifier.urihttp://hdl.handle.net/10722/155398-
dc.description.abstractNoncystic periventricular leukomalacia (PVL) in premature infants is becoming a predominant lesion form. However, detection of the gray matter (GM) lesions involved in this disease, which closely relate to the later cognitive and behavioral deficits, is challenging because of their subtle and transient nature observed by conventional MRI. This study evaluated manganese-enhanced MRI (MEMRI) for detecting such GM lesions in 7-day-old rats with mild hypoxic-ischemic (H-I) insult, a characteristic model of noncystic PVL. Group 1 (n = 6) and Group 2 (n = 8) were administered intraperitoneally with MnCl2 at hour 3 and day 7 after H-I insult, respectively. Control Group (n = 6) received no MnCl2. T1-, T2- and diffusion-weighted imaging (T1WI, T2WI and DWI, respectively) was performed. Animals were sacrificed for H&E staining, and immunohistochemical staining for glutamine synthetase (GS) and Mn-superoxide dismutase (Mn-SOD), which are two Mn-binding enzymes against glutamate toxicity and oxidative stress respectively in neurodegeneration. In Control Group, MRI appearance of H-I lesions normalized by day 7 after H-I insult. In Group 1, MEMRI provided the enhanced and prolonged GM lesion detection from day 3 up to day 21. In Group 2, similar Mn enhancement was observed, enabling day 8 detection of GM lesions that were invisible before Mn injection at day 7. These in vivo Mn-induced GM lesion enhancements were found to correlate with increased immunoactivities of GS and Mn-SOD. These findings suggest the potential utility of MEMRI in detecting the GM lesions that are otherwise undetectable using the conventional MRI techniques in late phase of mild H-I injury. © 2007.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimgen_US
dc.relation.ispartofNeuroImageen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnimals, Newbornen_US
dc.subject.meshBrain Mappingen_US
dc.subject.meshCerebral Cortex - Enzymology - Metabolism - Pathologyen_US
dc.subject.meshData Interpretation, Statisticalen_US
dc.subject.meshFemaleen_US
dc.subject.meshGlutamate-Ammonia Ligase - Metabolismen_US
dc.subject.meshGlutamic Acid - Toxicityen_US
dc.subject.meshHypoxia-Ischemia, Brain - Enzymology - Metabolism - Pathologyen_US
dc.subject.meshImage Processing, Computer-Assisteden_US
dc.subject.meshMagnetic Resonance Imaging - Methodsen_US
dc.subject.meshManganese Poisoning - Enzymology - Metabolism - Pathologyen_US
dc.subject.meshOxidative Stress - Physiologyen_US
dc.subject.meshPregnancyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshSuperoxide Dismutase - Metabolismen_US
dc.titleDetection of cortical gray matter lesion in the late phase of mild hypoxic-ischemic injury by manganese-enhanced MRIen_US
dc.typeArticleen_US
dc.identifier.emailWu, EX:ewu1@hkucc.hku.hken_US
dc.identifier.authorityWu, EX=rp00193en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.neuroimage.2007.09.009en_US
dc.identifier.pmid17949999-
dc.identifier.scopuseid_2-s2.0-36148968508en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-36148968508&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume39en_US
dc.identifier.issue2en_US
dc.identifier.spage669en_US
dc.identifier.epage679en_US
dc.identifier.isiWOS:000251634400013-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridYang, J=10041733800en_US
dc.identifier.scopusauthoridWu, EX=7202128034en_US

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