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Article: Neuroprotective effect of Coenzyme Q10 on ischemic hemisphere in aged mice with mutations in the amyloid precursor protein

TitleNeuroprotective effect of Coenzyme Q10 on ischemic hemisphere in aged mice with mutations in the amyloid precursor protein
Authors
Issue Date2007
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/neuaging
Citation
Neurobiology Of Aging, 2007, v. 28 n. 6, p. 877-882 How to Cite?
AbstractThis study was designed to test whether Coenzyme Q10 (CoQ10) supplementation has neuroprotective effect in aged, double-transgenic amyloid precursor protein (APP)/presenilin 1 (PS1), single transgenic APP and PS1 mice exposed to ischemic injury of the brain. Forty-eight mice (12 each of APP/PS1, APP, PS1 and wild-type) were studied. Half of each genotype groups (n = 6 per group) was treated with CoQ10 (1200 mg/kg/day) after ischemic injury and the other half with placebo. Magnetic resonance (MR) images were used to measure the volume of induced infarction (IFV), as well as the volume of the hemispheres and hippocampi. Significantly greater volumes of infarction and lesser volumes of hemisphere/hippocampus on the ischemic side were observed in APP/PS1 and APP mice than in PS1 and wild-type mice. This is consistent with amplification of the effect of ischemia in APP carriers. After 28 days of CoQ10 treatment, APP/PS1 or APP mutations have smaller infarct volumes, while the volumes of hemisphere and hippocampus on the infarcted side were larger than those treated with placebo. No differences between CoQ10- and placebo-treated groups in volumes of infarct, hemisphere and hippocampus were observed in PS1 and wild-type mice. We conclude that CoQ10 has a protective effect on the brain from infarction and atrophy induced by ischemic injury in aged and susceptible transgenic mice. © 2006 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/155367
ISSN
2015 Impact Factor: 5.153
2015 SCImago Journal Rankings: 2.613
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLi, Gen_US
dc.contributor.authorZou, Len_US
dc.contributor.authorJack Jr, CRen_US
dc.contributor.authorYang, Yen_US
dc.contributor.authorYang, ESen_US
dc.date.accessioned2012-08-08T08:33:06Z-
dc.date.available2012-08-08T08:33:06Z-
dc.date.issued2007en_US
dc.identifier.citationNeurobiology Of Aging, 2007, v. 28 n. 6, p. 877-882en_US
dc.identifier.issn0197-4580en_US
dc.identifier.urihttp://hdl.handle.net/10722/155367-
dc.description.abstractThis study was designed to test whether Coenzyme Q10 (CoQ10) supplementation has neuroprotective effect in aged, double-transgenic amyloid precursor protein (APP)/presenilin 1 (PS1), single transgenic APP and PS1 mice exposed to ischemic injury of the brain. Forty-eight mice (12 each of APP/PS1, APP, PS1 and wild-type) were studied. Half of each genotype groups (n = 6 per group) was treated with CoQ10 (1200 mg/kg/day) after ischemic injury and the other half with placebo. Magnetic resonance (MR) images were used to measure the volume of induced infarction (IFV), as well as the volume of the hemispheres and hippocampi. Significantly greater volumes of infarction and lesser volumes of hemisphere/hippocampus on the ischemic side were observed in APP/PS1 and APP mice than in PS1 and wild-type mice. This is consistent with amplification of the effect of ischemia in APP carriers. After 28 days of CoQ10 treatment, APP/PS1 or APP mutations have smaller infarct volumes, while the volumes of hemisphere and hippocampus on the infarcted side were larger than those treated with placebo. No differences between CoQ10- and placebo-treated groups in volumes of infarct, hemisphere and hippocampus were observed in PS1 and wild-type mice. We conclude that CoQ10 has a protective effect on the brain from infarction and atrophy induced by ischemic injury in aged and susceptible transgenic mice. © 2006 Elsevier Inc. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/neuagingen_US
dc.relation.ispartofNeurobiology of Agingen_US
dc.subject.meshAgingen_US
dc.subject.meshAmyloid Beta-Protein Precursor - Geneticsen_US
dc.subject.meshAnalysis Of Varianceen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCoenzymesen_US
dc.subject.meshFunctional Lateralityen_US
dc.subject.meshHippocampus - Drug Effects - Pathologyen_US
dc.subject.meshHumansen_US
dc.subject.meshIschemia - Pathology - Prevention & Controlen_US
dc.subject.meshMagnetic Resonance Imaging - Methodsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred C57blen_US
dc.subject.meshMice, Transgenicen_US
dc.subject.meshMutationen_US
dc.subject.meshNeuroprotective Agents - Therapeutic Useen_US
dc.subject.meshPresenilin-1 - Geneticsen_US
dc.subject.meshUbiquinone - Analogs & Derivatives - Therapeutic Useen_US
dc.titleNeuroprotective effect of Coenzyme Q10 on ischemic hemisphere in aged mice with mutations in the amyloid precursor proteinen_US
dc.typeArticleen_US
dc.identifier.emailYang, ES:esyang@hkueee.hku.hken_US
dc.identifier.authorityYang, ES=rp00199en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.neurobiolaging.2006.05.005en_US
dc.identifier.pmid16806588-
dc.identifier.scopuseid_2-s2.0-34247172100en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34247172100&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume28en_US
dc.identifier.issue6en_US
dc.identifier.spage877en_US
dc.identifier.epage882en_US
dc.identifier.isiWOS:000246253300008-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLi, G=35767974200en_US
dc.identifier.scopusauthoridZou, L=23391539300en_US
dc.identifier.scopusauthoridJack Jr, CR=18033457700en_US
dc.identifier.scopusauthoridYang, Y=7409387192en_US
dc.identifier.scopusauthoridYang, ES=7202021229en_US

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