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Article: Mapping Cyclic Change of Regional Myocardial Blood Volume Using Steady-State Susceptibility Effect of Iron Oxide Nanoparticles

TitleMapping Cyclic Change of Regional Myocardial Blood Volume Using Steady-State Susceptibility Effect of Iron Oxide Nanoparticles
Authors
Issue Date2004
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/1053-1807/
Citation
Journal Of Magnetic Resonance Imaging, 2004, v. 19 n. 1, p. 50-58 How to Cite?
AbstractPurpose: To demonstrate an in vivo magnetic resonance imaging (MRI) technique that maps the cyclic change of regional myocardial blood volume (MBV) during the cardiac cycle. Materials and Methods: The method is based on the dominant T 2* shortening effect of iron oxide nanoparticle-induced magnetic susceptibility perturbation in myocardium in the steady state. The technique was demonstrated in vivo with normal mouse hearts at 9.4 T. The regional MBV maps in left ventricular myocardium were computed from the steady-state pre- and post-monocrystalline iron oxide nanoparticle (MION) gradient echo (GE) cine images. Cyclic changes of MBV in normal mice were analyzed quantitatively in different transmural and angular locations. Results: High-resolution MBV maps at various cardiac points were obtained. The study showed a general regional MBV decrease from end-diastole (ED) to end-systole (ES). Percentage reductions were 18.2 ± 6.6%, P < 0.03 in the lateral wall and 24.7 ± 3.1%, P < 0.0002 in the interventricular septum. The heterogeneous characteristics of MBV transmural distribution were also reported. Conclusion: The steady-state susceptibility effect of intravascular superparamagnetic contrast agent (CA) can be used to map the cyclic change of regional MBV. This imaging approach is relatively simple and may provide a new perspective for functional assessment of the microvasculature in myocardium.
Persistent Identifierhttp://hdl.handle.net/10722/155236
ISSN
2015 Impact Factor: 3.25
2015 SCImago Journal Rankings: 1.683
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWu, EXen_US
dc.contributor.authorTang, Hen_US
dc.contributor.authorWong, KKen_US
dc.contributor.authorWang, Jen_US
dc.date.accessioned2012-08-08T08:32:29Z-
dc.date.available2012-08-08T08:32:29Z-
dc.date.issued2004en_US
dc.identifier.citationJournal Of Magnetic Resonance Imaging, 2004, v. 19 n. 1, p. 50-58en_US
dc.identifier.issn1053-1807en_US
dc.identifier.urihttp://hdl.handle.net/10722/155236-
dc.description.abstractPurpose: To demonstrate an in vivo magnetic resonance imaging (MRI) technique that maps the cyclic change of regional myocardial blood volume (MBV) during the cardiac cycle. Materials and Methods: The method is based on the dominant T 2* shortening effect of iron oxide nanoparticle-induced magnetic susceptibility perturbation in myocardium in the steady state. The technique was demonstrated in vivo with normal mouse hearts at 9.4 T. The regional MBV maps in left ventricular myocardium were computed from the steady-state pre- and post-monocrystalline iron oxide nanoparticle (MION) gradient echo (GE) cine images. Cyclic changes of MBV in normal mice were analyzed quantitatively in different transmural and angular locations. Results: High-resolution MBV maps at various cardiac points were obtained. The study showed a general regional MBV decrease from end-diastole (ED) to end-systole (ES). Percentage reductions were 18.2 ± 6.6%, P < 0.03 in the lateral wall and 24.7 ± 3.1%, P < 0.0002 in the interventricular septum. The heterogeneous characteristics of MBV transmural distribution were also reported. Conclusion: The steady-state susceptibility effect of intravascular superparamagnetic contrast agent (CA) can be used to map the cyclic change of regional MBV. This imaging approach is relatively simple and may provide a new perspective for functional assessment of the microvasculature in myocardium.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/1053-1807/en_US
dc.relation.ispartofJournal of Magnetic Resonance Imagingen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBlood Volumeen_US
dc.subject.meshIron - Diagnostic Useen_US
dc.subject.meshMagnetic Resonance Imaging - Methodsen_US
dc.subject.meshMiceen_US
dc.subject.meshMyocardiumen_US
dc.subject.meshNanotechnologyen_US
dc.subject.meshOxides - Diagnostic Useen_US
dc.subject.meshParticle Sizeen_US
dc.titleMapping Cyclic Change of Regional Myocardial Blood Volume Using Steady-State Susceptibility Effect of Iron Oxide Nanoparticlesen_US
dc.typeArticleen_US
dc.identifier.emailWu, EX:ewu1@hkucc.hku.hken_US
dc.identifier.authorityWu, EX=rp00193en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/jmri.10426en_US
dc.identifier.pmid14696220-
dc.identifier.scopuseid_2-s2.0-0347595439en_US
dc.identifier.hkuros90223-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0347595439&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume19en_US
dc.identifier.issue1en_US
dc.identifier.spage50en_US
dc.identifier.epage58en_US
dc.identifier.isiWOS:000188002000008-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridWu, EX=7202128034en_US
dc.identifier.scopusauthoridTang, H=36827331000en_US
dc.identifier.scopusauthoridWong, KK=35222708000en_US
dc.identifier.scopusauthoridWang, J=8061150000en_US

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