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Article: Left ventricular systolic performance in failing heart improved acutely by left ventricular reshaping

TitleLeft ventricular systolic performance in failing heart improved acutely by left ventricular reshaping
Authors
Issue Date2003
PublisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/jtcvs
Citation
Journal Of Thoracic And Cardiovascular Surgery, 2003, v. 126 n. 1, p. 56-65 How to Cite?
AbstractObjective: If the geometric distortion during dilated heart failure could be corrected, the tension on the myocytes would be decreased, thereby leading to an improvement in left ventricular systolic function. We tested the effects of the CardioClasp (CardioClasp Inc, Pine Brook, NJ), a left ventricular reshaping device, on the failing heart, and our empirical data were compared with computationally derived data. Methods: Heart failure was induced by 4-week rapid cardiac pacing. At the terminal experiment, an isolated failing heart preparation (isovolumic contraction, n = 5) or an intact failing heart in vivo (n = 7) was used. The effects of the reshaping device on left ventricular performance were assessed by the slopes (Ees) of the left ventricular end-systolic pressure-volume relations, hemodynamics, and echocardiograph before and after placing the CardioClasp on the heart. The change in Ees as the result of left ventricular reshaping was also estimated from computed theoretical analysis and compared with empirical data. Results: There was a significant change in left ventricular dimension after placing the CardioClasp on the heart. In isolated heart preparation, Ees significantly increased from 1.40 ± 0.44 mm Hg/mL to 2.42 ± 0.63 mm Hg/mL after placing the device on the heart but returned to the baseline level (1.46 ± 0.27 mm Hg) after removing it. Left ventricular developed pressure and left ventricular fractional area shortening were significantly increased as the result of left ventricular reshaping. Ees derived from computed theoretical analysis was highly correlated with confirming empirical data. Conclusions: The CardioClasp can reshape the left ventricle and improve left ventricular systolic performance in failing hearts.
Persistent Identifierhttp://hdl.handle.net/10722/155209
ISSN
2015 Impact Factor: 3.494
2015 SCImago Journal Rankings: 2.369
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHe, KLen_US
dc.contributor.authorShimizu, Jen_US
dc.contributor.authorYi, GHen_US
dc.contributor.authorGu, Aen_US
dc.contributor.authorKashem, MAen_US
dc.contributor.authorCrabbe, DLen_US
dc.contributor.authorPopilskis, Sen_US
dc.contributor.authorWu, EXen_US
dc.contributor.authorSantamore, WPen_US
dc.contributor.authorMelvin, Den_US
dc.contributor.authorWang, Jen_US
dc.date.accessioned2012-08-08T08:32:21Z-
dc.date.available2012-08-08T08:32:21Z-
dc.date.issued2003en_US
dc.identifier.citationJournal Of Thoracic And Cardiovascular Surgery, 2003, v. 126 n. 1, p. 56-65en_US
dc.identifier.issn0022-5223en_US
dc.identifier.urihttp://hdl.handle.net/10722/155209-
dc.description.abstractObjective: If the geometric distortion during dilated heart failure could be corrected, the tension on the myocytes would be decreased, thereby leading to an improvement in left ventricular systolic function. We tested the effects of the CardioClasp (CardioClasp Inc, Pine Brook, NJ), a left ventricular reshaping device, on the failing heart, and our empirical data were compared with computationally derived data. Methods: Heart failure was induced by 4-week rapid cardiac pacing. At the terminal experiment, an isolated failing heart preparation (isovolumic contraction, n = 5) or an intact failing heart in vivo (n = 7) was used. The effects of the reshaping device on left ventricular performance were assessed by the slopes (Ees) of the left ventricular end-systolic pressure-volume relations, hemodynamics, and echocardiograph before and after placing the CardioClasp on the heart. The change in Ees as the result of left ventricular reshaping was also estimated from computed theoretical analysis and compared with empirical data. Results: There was a significant change in left ventricular dimension after placing the CardioClasp on the heart. In isolated heart preparation, Ees significantly increased from 1.40 ± 0.44 mm Hg/mL to 2.42 ± 0.63 mm Hg/mL after placing the device on the heart but returned to the baseline level (1.46 ± 0.27 mm Hg) after removing it. Left ventricular developed pressure and left ventricular fractional area shortening were significantly increased as the result of left ventricular reshaping. Ees derived from computed theoretical analysis was highly correlated with confirming empirical data. Conclusions: The CardioClasp can reshape the left ventricle and improve left ventricular systolic performance in failing hearts.en_US
dc.languageengen_US
dc.publisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/jtcvsen_US
dc.relation.ispartofJournal of Thoracic and Cardiovascular Surgeryen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCardiac Pacing, Artificial - Adverse Effectsen_US
dc.subject.meshDisease Models, Animalen_US
dc.subject.meshDogsen_US
dc.subject.meshEchocardiographyen_US
dc.subject.meshHeart Failure - Etiology - Physiopathologyen_US
dc.subject.meshHeart Ventricles - Physiopathologyen_US
dc.subject.meshModels, Cardiovascularen_US
dc.subject.meshModels, Theoreticalen_US
dc.subject.meshMyocardial Contraction - Physiologyen_US
dc.subject.meshPredictive Value Of Testsen_US
dc.subject.meshStatistics As Topicen_US
dc.subject.meshStroke Volume - Physiologyen_US
dc.subject.meshVentricular Dysfunction, Left - Etiology - Physiopathologyen_US
dc.subject.meshVentricular Function, Left - Physiologyen_US
dc.subject.meshVentricular Remodeling - Physiologyen_US
dc.titleLeft ventricular systolic performance in failing heart improved acutely by left ventricular reshapingen_US
dc.typeArticleen_US
dc.identifier.emailWu, EX:ewu1@hkucc.hku.hken_US
dc.identifier.authorityWu, EX=rp00193en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0022-5223(02)73597-6en_US
dc.identifier.pmid12878939-
dc.identifier.scopuseid_2-s2.0-0041341990en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0041341990&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume126en_US
dc.identifier.issue1en_US
dc.identifier.spage56en_US
dc.identifier.epage65en_US
dc.identifier.isiWOS:000184365400008-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridHe, KL=7202010630en_US
dc.identifier.scopusauthoridShimizu, J=7202493574en_US
dc.identifier.scopusauthoridYi, GH=7101660739en_US
dc.identifier.scopusauthoridGu, A=7006612957en_US
dc.identifier.scopusauthoridKashem, MA=35428547900en_US
dc.identifier.scopusauthoridCrabbe, DL=7003303016en_US
dc.identifier.scopusauthoridPopilskis, S=6603522685en_US
dc.identifier.scopusauthoridWu, EX=7202128034en_US
dc.identifier.scopusauthoridSantamore, WP=7006209909en_US
dc.identifier.scopusauthoridMelvin, D=35511183200en_US
dc.identifier.scopusauthoridWang, J=8061150000en_US

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