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Article: High-resolution in vivo CBV mapping with MRI in wild-type mice

TitleHigh-resolution in vivo CBV mapping with MRI in wild-type mice
Authors
Wu, EXWong, KKAndrassy, MTang, H
KeywordsC57BL6/J
CBV
Cerebral blood volume
MION
Mouse
Issue Date2003
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0740-3194/
Citation
Magnetic Resonance In Medicine, 2003, v. 49 n. 4, p. 765-770 How to Cite?
DOI: http://dx.doi.org/10.1002/mrm.10425
AbstractNMR microimaging has the potential to elucidate cerebrovascular abnormalities in mouse models. In this study, the relative regional cerebral blood volume (CBV) map is presented for C57BL6/J wild-type mice. The CBV mapping was based on changes in the steady-state NMR transverse relaxation rate (ΔR 2) associated with the presence of a superparamagnetic intravascular contrast agent (MION) with a long blood halflife. The experiments were performed at 9.4 T at a voxel size of 100 μm x 100 μm x 600 μm. Fine details, such as the hippocampal and olfactory bulb area, were visualized in the CBV map. The relative regional CBV values of various brain regions were measured. The ΔR 2 dosage dependency and MION tissue clearance in mouse are also reported.© 2003 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/155184
ISSN
0740-3194
2023 Impact Factor: 3.0
2023 SCImago Journal Rankings: 1.343
ISI Accession Number ID
WOS:000182007200021
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorWu, EXen_US
dc.contributor.authorWong, KKen_US
dc.contributor.authorAndrassy, Men_US
dc.contributor.authorTang, Hen_US
dc.date.accessioned2012-08-08T08:32:14Z-
dc.date.available2012-08-08T08:32:14Z-
dc.date.issued2003en_US
dc.identifier.citationMagnetic Resonance In Medicine, 2003, v. 49 n. 4, p. 765-770en_US
dc.identifier.issn0740-3194en_US
dc.identifier.urihttp://hdl.handle.net/10722/155184-
dc.description.abstractNMR microimaging has the potential to elucidate cerebrovascular abnormalities in mouse models. In this study, the relative regional cerebral blood volume (CBV) map is presented for C57BL6/J wild-type mice. The CBV mapping was based on changes in the steady-state NMR transverse relaxation rate (ΔR 2) associated with the presence of a superparamagnetic intravascular contrast agent (MION) with a long blood halflife. The experiments were performed at 9.4 T at a voxel size of 100 μm x 100 μm x 600 μm. Fine details, such as the hippocampal and olfactory bulb area, were visualized in the CBV map. The relative regional CBV values of various brain regions were measured. The ΔR 2 dosage dependency and MION tissue clearance in mouse are also reported.© 2003 Wiley-Liss, Inc.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0740-3194/en_US
dc.relation.ispartofMagnetic Resonance in Medicineen_US
dc.subjectC57BL6/J-
dc.subjectCBV-
dc.subjectCerebral blood volume-
dc.subjectMION-
dc.subjectMouse-
dc.subject.meshAnimalsen_US
dc.subject.meshBlood Volume Determinationen_US
dc.subject.meshBrain - Anatomy & Histology - Blood Supplyen_US
dc.subject.meshCerebrovascular Circulation - Physiologyen_US
dc.subject.meshContrast Mediaen_US
dc.subject.meshMagnetic Resonance Imaging - Methodsen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred C57blen_US
dc.subject.meshStroke - Physiopathologyen_US
dc.titleHigh-resolution in vivo CBV mapping with MRI in wild-type miceen_US
dc.typeArticleen_US
dc.identifier.emailWu, EX:ewu1@hkucc.hku.hken_US
dc.identifier.authorityWu, EX=rp00193en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/mrm.10425en_US
dc.identifier.pmid12652549-
dc.identifier.scopuseid_2-s2.0-0037380109en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037380109&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume49en_US
dc.identifier.issue4en_US
dc.identifier.spage765en_US
dc.identifier.epage770en_US
dc.identifier.isiWOS:000182007200021-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridWu, EX=7202128034en_US
dc.identifier.scopusauthoridWong, KK=35222708000en_US
dc.identifier.scopusauthoridAndrassy, M=7004247190en_US
dc.identifier.scopusauthoridTang, H=36827331000en_US
dc.identifier.issnl0740-3194-

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