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Article: Imaging physiologic dysfunction neurotechnique of individual hippocampal subregions in humans and genetically modified mice

TitleImaging physiologic dysfunction neurotechnique of individual hippocampal subregions in humans and genetically modified mice
Authors
Issue Date2000
PublisherCell Press. The Journal's web site is located at http://www.elsevier.com/locate/neuron
Citation
Neuron, 2000, v. 28 n. 3, p. 653-664 How to Cite?
Abstract
We have developed a variant of functional magnetic resonance imaging (fMRI) designed to be sensitive to static neuronal function. This method is based on resting instead of dynamic changes in oxygen-dependent signal and therefore allows for a spatial resolution that can detect signal from different hippocampal subregions in human subjects as well as in mice. We found that hippocampal signal was significantly diminished in elderly subjects with memory decline compared to age-matched controls, and different subjects showed dysfunction in different subregions. Among healthy elders, signal intensity from the subiculum was correlated selectively with memory performance. This method does not require an activation task; it can be used in anesthetized normal and in genetically modified and cognitively impaired mice. In mice the signal was found to be sufficiently sensitive to detect functional changes in the absence of underlying anatomical changes.
Persistent Identifierhttp://hdl.handle.net/10722/155140
ISSN
2013 Impact Factor: 15.982
2013 SCImago Journal Rankings: 12.845
ISI Accession Number ID
References

 

Author Affiliations
  1. Columbia University in the City of New York
DC FieldValueLanguage
dc.contributor.authorSmall, SAen_US
dc.contributor.authorWu, EXen_US
dc.contributor.authorBartsch, Den_US
dc.contributor.authorPerera, GMen_US
dc.contributor.authorLacefield, COen_US
dc.contributor.authorDelapaz, Ren_US
dc.contributor.authorMayeux, Ren_US
dc.contributor.authorStern, Yen_US
dc.contributor.authorKandel, ERen_US
dc.date.accessioned2012-08-08T08:32:02Z-
dc.date.available2012-08-08T08:32:02Z-
dc.date.issued2000en_US
dc.identifier.citationNeuron, 2000, v. 28 n. 3, p. 653-664en_US
dc.identifier.issn0896-6273en_US
dc.identifier.urihttp://hdl.handle.net/10722/155140-
dc.description.abstractWe have developed a variant of functional magnetic resonance imaging (fMRI) designed to be sensitive to static neuronal function. This method is based on resting instead of dynamic changes in oxygen-dependent signal and therefore allows for a spatial resolution that can detect signal from different hippocampal subregions in human subjects as well as in mice. We found that hippocampal signal was significantly diminished in elderly subjects with memory decline compared to age-matched controls, and different subjects showed dysfunction in different subregions. Among healthy elders, signal intensity from the subiculum was correlated selectively with memory performance. This method does not require an activation task; it can be used in anesthetized normal and in genetically modified and cognitively impaired mice. In mice the signal was found to be sufficiently sensitive to detect functional changes in the absence of underlying anatomical changes.en_US
dc.languageengen_US
dc.publisherCell Press. The Journal's web site is located at http://www.elsevier.com/locate/neuronen_US
dc.relation.ispartofNeuronen_US
dc.subject.meshAgeden_US
dc.subject.meshAnimalsen_US
dc.subject.meshBrain Diseases - Complications - Diagnosis - Physiopathologyen_US
dc.subject.meshCognition Disorders - Diagnosis - Etiology - Physiopathologyen_US
dc.subject.meshHippocampus - Metabolism - Pathology - Physiopathologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMagnetic Resonance Imaging - Methodsen_US
dc.subject.meshMemoryen_US
dc.subject.meshMemory Disorders - Diagnosis - Etiology - Physiopathologyen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred C57blen_US
dc.subject.meshMice, Transgenicen_US
dc.subject.meshNeurons - Metabolismen_US
dc.subject.meshOxygen - Metabolismen_US
dc.subject.meshPredictive Value Of Testsen_US
dc.subject.meshSensitivity And Specificityen_US
dc.titleImaging physiologic dysfunction neurotechnique of individual hippocampal subregions in humans and genetically modified miceen_US
dc.typeArticleen_US
dc.identifier.emailWu, EX:ewu1@hkucc.hku.hken_US
dc.identifier.authorityWu, EX=rp00193en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0896-6273(00)00144-6en_US
dc.identifier.pmid11163257en_US
dc.identifier.scopuseid_2-s2.0-0034517627en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034517627&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume28en_US
dc.identifier.issue3en_US
dc.identifier.spage653en_US
dc.identifier.epage664en_US
dc.identifier.isiWOS:000166057500007-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridSmall, SA=7102189047en_US
dc.identifier.scopusauthoridWu, EX=7202128034en_US
dc.identifier.scopusauthoridBartsch, D=7101724850en_US
dc.identifier.scopusauthoridPerera, GM=35596592800en_US
dc.identifier.scopusauthoridLacefield, CO=6507716646en_US
dc.identifier.scopusauthoridDeLaPaz, R=7003483775en_US
dc.identifier.scopusauthoridMayeux, R=7101793222en_US
dc.identifier.scopusauthoridStern, Y=7103273845en_US
dc.identifier.scopusauthoridKandel, ER=7102435048en_US

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