Article: Imaging physiologic dysfunction neurotechnique of individual hippocampal subregions in humans and genetically modified mice

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TitleImaging physiologic dysfunction neurotechnique of individual hippocampal subregions in humans and genetically modified mice
AuthorsSmall, SA1
Wu, EX1
Bartsch, D1
Perera, GM1
Lacefield, CO1
Delapaz, R1
Mayeux, R1
Stern, Y1
Kandel, ER1
Issue Date2000
PublisherCell Press. The Journal's web site is located at http://www.elsevier.com/locate/neuron
CitationNeuron, 2000, v. 28 n. 3, p. 653-664 [How to Cite?]
DOI: http://dx.doi.org/10.1016/S0896-6273(00)00144-6
AbstractWe have developed a variant of functional magnetic resonance imaging (fMRI) designed to be sensitive to static neuronal function. This method is based on resting instead of dynamic changes in oxygen-dependent signal and therefore allows for a spatial resolution that can detect signal from different hippocampal subregions in human subjects as well as in mice. We found that hippocampal signal was significantly diminished in elderly subjects with memory decline compared to age-matched controls, and different subjects showed dysfunction in different subregions. Among healthy elders, signal intensity from the subiculum was correlated selectively with memory performance. This method does not require an activation task; it can be used in anesthetized normal and in genetically modified and cognitively impaired mice. In mice the signal was found to be sufficiently sensitive to detect functional changes in the absence of underlying anatomical changes.
ISSN0896-6273
2011 Impact Factor: 14.736
2011 SCImago Journal Rankings: 2.753
DOIhttp://dx.doi.org/10.1016/S0896-6273(00)00144-6
ISI Accession Number IDWOS:000166057500007
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorSmall, SA
dc.contributor.authorWu, EX
dc.contributor.authorBartsch, D
dc.contributor.authorPerera, GM
dc.contributor.authorLacefield, CO
dc.contributor.authorDelapaz, R
dc.contributor.authorMayeux, R
dc.contributor.authorStern, Y
dc.contributor.authorKandel, ER
dc.date.accessioned2012-08-08T08:32:02Z
dc.date.available2012-08-08T08:32:02Z
dc.date.issued2000
dc.description.abstractWe have developed a variant of functional magnetic resonance imaging (fMRI) designed to be sensitive to static neuronal function. This method is based on resting instead of dynamic changes in oxygen-dependent signal and therefore allows for a spatial resolution that can detect signal from different hippocampal subregions in human subjects as well as in mice. We found that hippocampal signal was significantly diminished in elderly subjects with memory decline compared to age-matched controls, and different subjects showed dysfunction in different subregions. Among healthy elders, signal intensity from the subiculum was correlated selectively with memory performance. This method does not require an activation task; it can be used in anesthetized normal and in genetically modified and cognitively impaired mice. In mice the signal was found to be sufficiently sensitive to detect functional changes in the absence of underlying anatomical changes.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationNeuron, 2000, v. 28 n. 3, p. 653-664 [How to Cite?]
DOI: http://dx.doi.org/10.1016/S0896-6273(00)00144-6
dc.identifier.doihttp://dx.doi.org/10.1016/S0896-6273(00)00144-6
dc.identifier.epage664
dc.identifier.isiWOS:000166057500007
dc.identifier.issn0896-6273
2011 Impact Factor: 14.736
2011 SCImago Journal Rankings: 2.753
dc.identifier.issue3
dc.identifier.pmid11163257
dc.identifier.scopuseid_2-s2.0-0034517627
dc.identifier.spage653
dc.identifier.urihttp://hdl.handle.net/10722/155140
dc.identifier.volume28
dc.languageeng
dc.publisherCell Press. The Journal's web site is located at http://www.elsevier.com/locate/neuron
dc.publisher.placeUnited States
dc.relation.ispartofNeuron
dc.relation.referencesReferences in Scopus
dc.subject.meshAged
dc.subject.meshAnimals
dc.subject.meshBrain Diseases - Complications - Diagnosis - Physiopathology
dc.subject.meshCognition Disorders - Diagnosis - Etiology - Physiopathology
dc.subject.meshHippocampus - Metabolism - Pathology - Physiopathology
dc.subject.meshHumans
dc.subject.meshMagnetic Resonance Imaging - Methods
dc.subject.meshMemory
dc.subject.meshMemory Disorders - Diagnosis - Etiology - Physiopathology
dc.subject.meshMice
dc.subject.meshMice, Inbred C57bl
dc.subject.meshMice, Transgenic
dc.subject.meshNeurons - Metabolism
dc.subject.meshOxygen - Metabolism
dc.subject.meshPredictive Value Of Tests
dc.subject.meshSensitivity And Specificity
dc.titleImaging physiologic dysfunction neurotechnique of individual hippocampal subregions in humans and genetically modified mice
dc.typeArticle
Author Affiliations
  1. Columbia University in the City of New York