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Article: Treatment of irradiated mandibles with mesenchymal stem cells transfected with bone morphogenetic protein 2/7

TitleTreatment of irradiated mandibles with mesenchymal stem cells transfected with bone morphogenetic protein 2/7
Authors
Issue Date2012
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/joms
Citation
Journal of Oral and Maxillofacial Surgery, 2012, v. 70 n. 7, p. 1711-1716 How to Cite?
AbstractPURPOSE: The study aimed to evaluate whether mesenchymal stem cells transfected with bone morphogenetic protein (BMP) 2/7 could increase bone regeneration after radiotherapy using a rabbit model of mandibular distraction osteogenesis. MATERIALS AND METHODS: Twelve rabbits were randomly assigned to the sham control, radiotherapy control, nontransfected mesenchymal stem cells (MSCs), and MSCs transfected with BMP-2/7 groups. All rabbits, except those in the sham control group, received preoperative radiation of 9 Gy for 5 fractions. One month after radiotherapy, all rabbits underwent unilateral mandibular distraction at a rate of 0.9 mm/d for 11 days. At the end of active distraction, MSCs combined with bovine collagen were injected into the distraction zone. After 4 weeks of consolidation, the mandibular samples were collected and subjected to radiographic, microcomputed tomographic, and histologic examinations. RESULTS: By radiographic examination, animals injected with nontransfected MSCs or MSCs encoding BMP-2/7 exhibited more bone formation than the control groups. Histologic examination showed that the group with MSCs encoding BMP-2/7 had a more mature medullary cavity than the nontransfected MSCs group. CONCLUSIONS: MSCs encoding BMP-2/7 can increase bone healing in irradiated mandibular bone.
Persistent Identifierhttp://hdl.handle.net/10722/154721
ISSN
2015 Impact Factor: 1.631
2015 SCImago Journal Rankings: 0.824
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhang, WBen_HK
dc.contributor.authorZheng, Len_HK
dc.contributor.authorChua, DTTen_HK
dc.contributor.authorCheung, LKen_HK
dc.date.accessioned2012-08-08T08:27:07Z-
dc.date.available2012-08-08T08:27:07Z-
dc.date.issued2012en_HK
dc.identifier.citationJournal of Oral and Maxillofacial Surgery, 2012, v. 70 n. 7, p. 1711-1716en_HK
dc.identifier.issn0278-2391en_HK
dc.identifier.urihttp://hdl.handle.net/10722/154721-
dc.description.abstractPURPOSE: The study aimed to evaluate whether mesenchymal stem cells transfected with bone morphogenetic protein (BMP) 2/7 could increase bone regeneration after radiotherapy using a rabbit model of mandibular distraction osteogenesis. MATERIALS AND METHODS: Twelve rabbits were randomly assigned to the sham control, radiotherapy control, nontransfected mesenchymal stem cells (MSCs), and MSCs transfected with BMP-2/7 groups. All rabbits, except those in the sham control group, received preoperative radiation of 9 Gy for 5 fractions. One month after radiotherapy, all rabbits underwent unilateral mandibular distraction at a rate of 0.9 mm/d for 11 days. At the end of active distraction, MSCs combined with bovine collagen were injected into the distraction zone. After 4 weeks of consolidation, the mandibular samples were collected and subjected to radiographic, microcomputed tomographic, and histologic examinations. RESULTS: By radiographic examination, animals injected with nontransfected MSCs or MSCs encoding BMP-2/7 exhibited more bone formation than the control groups. Histologic examination showed that the group with MSCs encoding BMP-2/7 had a more mature medullary cavity than the nontransfected MSCs group. CONCLUSIONS: MSCs encoding BMP-2/7 can increase bone healing in irradiated mandibular bone.en_HK
dc.languageengen_US
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/jomsen_HK
dc.relation.ispartofJournal of Oral and Maxillofacial Surgeryen_HK
dc.subject.meshBone Morphogenetic Protein 2 - genetics-
dc.subject.meshBone Morphogenetic Protein 7 - genetics-
dc.subject.meshBone Regeneration - physiology-
dc.subject.meshMandible - pathology - radiation effects - surgery-
dc.subject.meshMesenchymal Stem Cell Transplantation - methods-
dc.subject.meshMesenchymal Stromal Cells - enzymology-
dc.subject.meshTransfection-
dc.titleTreatment of irradiated mandibles with mesenchymal stem cells transfected with bone morphogenetic protein 2/7en_HK
dc.typeArticleen_HK
dc.identifier.emailZheng, L: lwzheng@hku.hken_HK
dc.identifier.emailChua, DTT: dttchua@hkucc.hku.hken_HK
dc.identifier.emailCheung, LK: lkcheung@hkucc.hku.hken_HK
dc.identifier.authorityZheng, L=rp01411en_HK
dc.identifier.authorityChua, DTT=rp00415en_HK
dc.identifier.authorityCheung, LK=rp00013en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.joms.2012.01.022en_HK
dc.identifier.pmid22580096-
dc.identifier.scopuseid_2-s2.0-84862235915en_HK
dc.identifier.hkuros204635-
dc.identifier.hkuros226145-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84862235915&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume70en_HK
dc.identifier.issue7en_HK
dc.identifier.spage1711en_HK
dc.identifier.epage1716en_HK
dc.identifier.isiWOS:000305812000037-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCheung, LK=7102302747en_HK
dc.identifier.scopusauthoridChua, DTT=7006773480en_HK
dc.identifier.scopusauthoridZheng, LW=11241247300en_HK
dc.identifier.scopusauthoridZhang, WB=37022069200en_HK

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