File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Inhibitory effect of quercetin on periodontal pathogens.

TitleInhibitory effect of quercetin on periodontal pathogens.
Authors
Issue Date2008
PublisherRoyal Australasian College of Dental Surgeons. The Journal's web site is located at http://www.racds.org
Citation
Annals Of The Royal Australasian College Of Dental Surgeons, 2008, v. 19, p. 157-158 How to Cite?
AbstractPeriodontal disease and associated bone loss can severely hinder orthodontic treatment. Actinobacillus actinomycetemcomitans (Aa) and Porphyromonas gingivalis (Pg) are bacteria which are strongly associated with this type of bone loss. Quercetin, a unique flavonoid, which is found in many common foods including apples, onions and tea may have a effect against these bacteria. To study the effect of quercetin on the in vitro growth of periodontal pathogens Aa and Pg. The antimicrobial effects were determined in vitro using a broth dilution assay. Aa and Pg were grown to a density of 10(7) to 10(8) cfu/mL and subsequently incubated with test solutions of quercetin at different concentrations (0.025 g/mL, 0.05 g/mL, and 0.1 g/ mL). 0.2% chlorhexidine was used as the positive control and 0.9% sodium chloride (NaCl) as the negative control. Aliquots for the growth assay were taken as soon as the solutions were mixed, and after 1, 3, 6, and 24 hours of incubation in an anaerobic chamber for Aa and Pg. Colonies appearing on the blood agar plates were visually counted after three days for Aa and 5 days for Pg. This study demonstrated that quercetin is a potent antimicrobial agent. When Aa and Pg were incubated with quercetin, their growth began to be inhibited at 1 hour. Aa, shows a transient inhibitory effect for 1 to 12 hours after which the antimicrobial effect gradually decreasds. With Pg, the effect increased with time and complete inhibition was achieved with concentrations of 0.1 g/mL, 0.05 g/mL and 0.025 g/mL by 24 hours. No significant difference was found between the chlorhexidine group and the quercetin solution after 24 hours of incubation. Quercetin has an inhibitory effect on Aa and Pg.
Persistent Identifierhttp://hdl.handle.net/10722/154714
ISSN
2015 SCImago Journal Rankings: 0.101

 

DC FieldValueLanguage
dc.contributor.authorGeoghegan, Fen_US
dc.contributor.authorTsui, VWen_US
dc.contributor.authorWong, RWen_US
dc.contributor.authorRabie, ABen_US
dc.date.accessioned2012-08-08T08:27:04Z-
dc.date.available2012-08-08T08:27:04Z-
dc.date.issued2008en_US
dc.identifier.citationAnnals Of The Royal Australasian College Of Dental Surgeons, 2008, v. 19, p. 157-158en_US
dc.identifier.issn0158-1570en_US
dc.identifier.urihttp://hdl.handle.net/10722/154714-
dc.description.abstractPeriodontal disease and associated bone loss can severely hinder orthodontic treatment. Actinobacillus actinomycetemcomitans (Aa) and Porphyromonas gingivalis (Pg) are bacteria which are strongly associated with this type of bone loss. Quercetin, a unique flavonoid, which is found in many common foods including apples, onions and tea may have a effect against these bacteria. To study the effect of quercetin on the in vitro growth of periodontal pathogens Aa and Pg. The antimicrobial effects were determined in vitro using a broth dilution assay. Aa and Pg were grown to a density of 10(7) to 10(8) cfu/mL and subsequently incubated with test solutions of quercetin at different concentrations (0.025 g/mL, 0.05 g/mL, and 0.1 g/ mL). 0.2% chlorhexidine was used as the positive control and 0.9% sodium chloride (NaCl) as the negative control. Aliquots for the growth assay were taken as soon as the solutions were mixed, and after 1, 3, 6, and 24 hours of incubation in an anaerobic chamber for Aa and Pg. Colonies appearing on the blood agar plates were visually counted after three days for Aa and 5 days for Pg. This study demonstrated that quercetin is a potent antimicrobial agent. When Aa and Pg were incubated with quercetin, their growth began to be inhibited at 1 hour. Aa, shows a transient inhibitory effect for 1 to 12 hours after which the antimicrobial effect gradually decreasds. With Pg, the effect increased with time and complete inhibition was achieved with concentrations of 0.1 g/mL, 0.05 g/mL and 0.025 g/mL by 24 hours. No significant difference was found between the chlorhexidine group and the quercetin solution after 24 hours of incubation. Quercetin has an inhibitory effect on Aa and Pg.en_US
dc.languageengen_US
dc.publisherRoyal Australasian College of Dental Surgeons. The Journal's web site is located at http://www.racds.orgen_US
dc.relation.ispartofAnnals of the Royal Australasian College of Dental Surgeonsen_US
dc.subject.meshActinobacillus Actinomycetemcomitans - Drug Effectsen_US
dc.subject.meshAnti-Infective Agents, Local - Pharmacologyen_US
dc.subject.meshAntioxidants - Pharmacologyen_US
dc.subject.meshChlorhexidine - Pharmacologyen_US
dc.subject.meshColony Count, Microbialen_US
dc.subject.meshCulture Mediaen_US
dc.subject.meshPeriodontal Diseases - Microbiologyen_US
dc.subject.meshPorphyromonas Gingivalis - Drug Effectsen_US
dc.subject.meshQuercetin - Pharmacologyen_US
dc.titleInhibitory effect of quercetin on periodontal pathogens.en_US
dc.typeArticleen_US
dc.identifier.emailRabie, AB:rabie@hku.hken_US
dc.identifier.authorityRabie, AB=rp00029en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid22073470-
dc.identifier.scopuseid_2-s2.0-84859398782en_US
dc.identifier.hkuros153925-
dc.identifier.volume19en_US
dc.identifier.spage157en_US
dc.identifier.epage158en_US
dc.publisher.placeAustraliaen_US
dc.identifier.scopusauthoridGeoghegan, F=36672849000en_US
dc.identifier.scopusauthoridTsui, VW=23978707000en_US
dc.identifier.scopusauthoridWong, RW=55175023100en_US
dc.identifier.scopusauthoridRabie, AB=7007172734en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats