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Article: Potent antifungal activity of pure compounds from traditional Chinese medicine extracts against six oral candida species and the synergy with fluconazole against azole-resistant Candida albicans

TitlePotent antifungal activity of pure compounds from traditional Chinese medicine extracts against six oral candida species and the synergy with fluconazole against azole-resistant Candida albicans
Authors
Issue Date2012
PublisherOxford University Press. The Journal's web site is located at http://ecam.oxfordjournals.org/
Citation
Evidence-Based Complementary And Alternative Medicine, 2012, v. 2012 How to Cite?
AbstractThis study was designed to evaluate the in vitro antifungal activities of four traditional Chinese medicine (TCM) extracts. The inhibitory effects of pseudolaric acid B, gentiopicrin, rhein, and alion were assessed using standard disk diffusion and broth microdilution assays. They were tested against six oral Candida species, Candida albicans, Candida glabrata, Candida tropicalis, Candida krusei, Candida dubliniensis, and Candida guilliermondii, including clinical isolates from HIV-negative, HIV-positive, and Sjgren's syndrome patients. It was found that pseudolaric acid B had the most potent antifungal effect and showed similar antifungal activity to all six Candida spp, and to isolates from HIV-negative, HIV-positive, and Sjgren's syndrome patients. The MIC values ranged from 16 to 128 μg/mL. More interestingly, a synergistic effect of pseudolaric acid B in combination with fluconazole was observed. We suggest that pseudolaric acid B might be a potential therapeutic fungicidal agent in treating oral candidiasis. Copyright 2012 Zhimin Yan et al.
Persistent Identifierhttp://hdl.handle.net/10722/154706
ISSN
2015 Impact Factor: 1.931
2015 SCImago Journal Rankings: 0.615
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYan, Zen_US
dc.contributor.authorHua, Hen_US
dc.contributor.authorXu, Yen_US
dc.contributor.authorSamaranayake, LPen_US
dc.date.accessioned2012-08-08T08:27:01Z-
dc.date.available2012-08-08T08:27:01Z-
dc.date.issued2012en_US
dc.identifier.citationEvidence-Based Complementary And Alternative Medicine, 2012, v. 2012en_US
dc.identifier.issn1741-427Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/154706-
dc.description.abstractThis study was designed to evaluate the in vitro antifungal activities of four traditional Chinese medicine (TCM) extracts. The inhibitory effects of pseudolaric acid B, gentiopicrin, rhein, and alion were assessed using standard disk diffusion and broth microdilution assays. They were tested against six oral Candida species, Candida albicans, Candida glabrata, Candida tropicalis, Candida krusei, Candida dubliniensis, and Candida guilliermondii, including clinical isolates from HIV-negative, HIV-positive, and Sjgren's syndrome patients. It was found that pseudolaric acid B had the most potent antifungal effect and showed similar antifungal activity to all six Candida spp, and to isolates from HIV-negative, HIV-positive, and Sjgren's syndrome patients. The MIC values ranged from 16 to 128 μg/mL. More interestingly, a synergistic effect of pseudolaric acid B in combination with fluconazole was observed. We suggest that pseudolaric acid B might be a potential therapeutic fungicidal agent in treating oral candidiasis. Copyright 2012 Zhimin Yan et al.en_US
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://ecam.oxfordjournals.org/en_US
dc.relation.ispartofEvidence-based Complementary and Alternative Medicineen_US
dc.titlePotent antifungal activity of pure compounds from traditional Chinese medicine extracts against six oral candida species and the synergy with fluconazole against azole-resistant Candida albicansen_US
dc.typeArticleen_US
dc.identifier.emailSamaranayake, LP:lakshman@hku.hken_US
dc.identifier.authoritySamaranayake, LP=rp00023en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1155/2012/106583en_US
dc.identifier.scopuseid_2-s2.0-84863268234-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84858259469&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume2012en_US
dc.identifier.isiWOS:000301356500001-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridYan, Z=55094076000en_US
dc.identifier.scopusauthoridHua, H=21734738900en_US
dc.identifier.scopusauthoridXu, Y=55088256600en_US
dc.identifier.scopusauthoridSamaranayake, LP=7102761002en_US

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