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Article: Osseointegration - communication of cells

TitleOsseointegration - communication of cells
Authors
KeywordsAngiogenesis
Bone Morphogenetic Proteins
Chemokines
Cytokines
Extracellular Matrix
Growth Factors
Osseointegration
Osteoblast
Osteoclastogenesis
Wound Healing
Issue Date2012
PublisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CLR
Citation
Clinical Oral Implants Research, 2012, v. 23 n. 10, p. 1127-1135 How to Cite?
AbstractBackground: The article provides the scientific documentation for the 3D animated film - "Osseointegration - Communication of cells". Aim: The aim of this article and of the film is to visualise the molecular and cellular events during the healing of an osseous wound after installation of a dental implant with special emphasis on the process of osseointegration. Material and Results: In this review article for didactic reasons the concept of the four phases of a healing soft tissue wound was transferred to a bone wound after insertion of a dental implant: haemostasis, inflammatory phase, proliferative phase and remodelling phase. Wound healing throughout these phases is the result of a coordinated action of different cell types which communicate with each other by their interaction using signalling molecules like cytokines, extracellular matrix proteins and small molecules. A regular sequence of cell types controlled by adequate concentrations of signalling molecules results in undisturbed healing. Disturbed healing is associated with a continuation of the early inflammatory phase and the development of a toxic wound environment. The latter is characterized by high counts of polymorphnuclear cells, high concentrations of toxic radicals and proteolytic enzymes and low concentrations of growth factors and extracellular matrix molecules. Clinically the development of a toxic wound environment should be avoided, e.g. by antibacterial measures. Discussion and Conclusion: Experiencing implant osseointegration as a biological process may provide the clinician new targets to improve the therapy with dental implants. © 2011 John Wiley & Sons A/S.
Persistent Identifierhttp://hdl.handle.net/10722/154688
ISSN
2015 Impact Factor: 3.464
2015 SCImago Journal Rankings: 1.427
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTerheyden, Hen_US
dc.contributor.authorLang, NPen_US
dc.contributor.authorBierbaum, Sen_US
dc.contributor.authorStadlinger, Ben_US
dc.date.accessioned2012-08-08T08:26:55Z-
dc.date.available2012-08-08T08:26:55Z-
dc.date.issued2012en_US
dc.identifier.citationClinical Oral Implants Research, 2012, v. 23 n. 10, p. 1127-1135en_US
dc.identifier.issn0905-7161en_US
dc.identifier.urihttp://hdl.handle.net/10722/154688-
dc.description.abstractBackground: The article provides the scientific documentation for the 3D animated film - "Osseointegration - Communication of cells". Aim: The aim of this article and of the film is to visualise the molecular and cellular events during the healing of an osseous wound after installation of a dental implant with special emphasis on the process of osseointegration. Material and Results: In this review article for didactic reasons the concept of the four phases of a healing soft tissue wound was transferred to a bone wound after insertion of a dental implant: haemostasis, inflammatory phase, proliferative phase and remodelling phase. Wound healing throughout these phases is the result of a coordinated action of different cell types which communicate with each other by their interaction using signalling molecules like cytokines, extracellular matrix proteins and small molecules. A regular sequence of cell types controlled by adequate concentrations of signalling molecules results in undisturbed healing. Disturbed healing is associated with a continuation of the early inflammatory phase and the development of a toxic wound environment. The latter is characterized by high counts of polymorphnuclear cells, high concentrations of toxic radicals and proteolytic enzymes and low concentrations of growth factors and extracellular matrix molecules. Clinically the development of a toxic wound environment should be avoided, e.g. by antibacterial measures. Discussion and Conclusion: Experiencing implant osseointegration as a biological process may provide the clinician new targets to improve the therapy with dental implants. © 2011 John Wiley & Sons A/S.en_US
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CLRen_US
dc.relation.ispartofClinical Oral Implants Researchen_US
dc.subjectAngiogenesisen_US
dc.subjectBone Morphogenetic Proteinsen_US
dc.subjectChemokinesen_US
dc.subjectCytokinesen_US
dc.subjectExtracellular Matrixen_US
dc.subjectGrowth Factorsen_US
dc.subjectOsseointegrationen_US
dc.subjectOsteoblasten_US
dc.subjectOsteoclastogenesisen_US
dc.subjectWound Healingen_US
dc.titleOsseointegration - communication of cellsen_US
dc.typeArticleen_US
dc.identifier.emailLang, NP:nplang@hkucc.hku.hken_US
dc.identifier.authorityLang, NP=rp00031en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1600-0501.2011.02327.xen_US
dc.identifier.pmid22092345-
dc.identifier.scopuseid_2-s2.0-84866479348en_US
dc.identifier.isiWOS:000308938600001-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridTerheyden, H=7003776445en_US
dc.identifier.scopusauthoridLang, NP=7201577367en_US
dc.identifier.scopusauthoridBierbaum, S=6603007020en_US
dc.identifier.scopusauthoridStadlinger, B=35254264800en_US

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