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Article: Diagnostic value of nonlinear optical signals from collagen matrix in the detection of epithelial precancer
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TitleDiagnostic value of nonlinear optical signals from collagen matrix in the detection of epithelial precancer
 
AuthorsZheng, W1 3
Li, D3
Li, S2 4
Zeng, Y3
Yang, Y2
Qu, JY3
 
Issue Date2011
 
PublisherOptical Society of America. The Journal's web site is located at http://www.opticsinfobase.org/current.cfm?journal=3
 
CitationOptics Letters, 2011, v. 36 n. 18, p. 3620-3622 [How to Cite?]
DOI: http://dx.doi.org/10.1364/OL.36.003620
 
AbstractDuring precancer development in epithelium, neoplastic cells remodel the underlying stroma, for example, the basement membrane, capillaries, fibroblasts, and extracellular matrix. The purpose of this study is to investigate the relationship between the nonlinear optical signals from the collagen matrix in stroma and the progression of early epithelial carcinogenesis. Two-photon excited fluorescence (TPEF) and second harmonic generation (SHG) signals were measured from the stroma of hamster oral cheek pouch in vivo. We found that three features, including the intensity ratio of TPEF over SHG, the spatial frequency distribution, and the texture feature of SHG images, provide the quantitative identification of epithelial precancer at different pathologic stages. We demonstrated that the combination of all three features by using a support vector machine algorithm can significantly improve the accuracy in the detection of epithelial precancer.
 
ISSN0146-9592
2013 Impact Factor: 3.179
 
DOIhttp://dx.doi.org/10.1364/OL.36.003620
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorZheng, W
 
dc.contributor.authorLi, D
 
dc.contributor.authorLi, S
 
dc.contributor.authorZeng, Y
 
dc.contributor.authorYang, Y
 
dc.contributor.authorQu, JY
 
dc.date.accessioned2012-08-08T08:26:52Z
 
dc.date.available2012-08-08T08:26:52Z
 
dc.date.issued2011
 
dc.description.abstractDuring precancer development in epithelium, neoplastic cells remodel the underlying stroma, for example, the basement membrane, capillaries, fibroblasts, and extracellular matrix. The purpose of this study is to investigate the relationship between the nonlinear optical signals from the collagen matrix in stroma and the progression of early epithelial carcinogenesis. Two-photon excited fluorescence (TPEF) and second harmonic generation (SHG) signals were measured from the stroma of hamster oral cheek pouch in vivo. We found that three features, including the intensity ratio of TPEF over SHG, the spatial frequency distribution, and the texture feature of SHG images, provide the quantitative identification of epithelial precancer at different pathologic stages. We demonstrated that the combination of all three features by using a support vector machine algorithm can significantly improve the accuracy in the detection of epithelial precancer.
 
dc.description.naturepublished_or_final_version
 
dc.identifier.citationOptics Letters, 2011, v. 36 n. 18, p. 3620-3622 [How to Cite?]
DOI: http://dx.doi.org/10.1364/OL.36.003620
 
dc.identifier.doihttp://dx.doi.org/10.1364/OL.36.003620
 
dc.identifier.eissn1539-4794
 
dc.identifier.epage3622
 
dc.identifier.hkuros206870
 
dc.identifier.issn0146-9592
2013 Impact Factor: 3.179
 
dc.identifier.issue18
 
dc.identifier.pmid21931410
 
dc.identifier.scopuseid_2-s2.0-80052952921
 
dc.identifier.spage3620
 
dc.identifier.urihttp://hdl.handle.net/10722/154678
 
dc.identifier.volume36
 
dc.languageeng
 
dc.publisherOptical Society of America. The Journal's web site is located at http://www.opticsinfobase.org/current.cfm?journal=3
 
dc.publisher.placeUnited States
 
dc.relation.ispartofOptics Letters
 
dc.relation.referencesReferences in Scopus
 
dc.rightsThis paper was published in [Optics Letters] and is made available as an electronic reprint with the permission of OSA. The paper can be found at the following URL on the OSA website: [http://www.opticsinfobase.org/ol/abstract.cfm?uri=ol-36-18-3620]. Systematic or multiple reproduction or distribution to multiple locations via electronic or other means is prohibited and is subject to penalties under law.
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.subject.meshCollagen - metabolism
 
dc.subject.meshNeoplasms, Glandular and Epithelial - diagnosis - metabolism - pathology
 
dc.subject.meshNonlinear Dynamics
 
dc.subject.meshOptical Processes
 
dc.subject.meshPrecancerous Conditions - diagnosis - metabolism - pathology
 
dc.titleDiagnostic value of nonlinear optical signals from collagen matrix in the detection of epithelial precancer
 
dc.typeArticle
 
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<contributor.author>Yang, Y</contributor.author>
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Author Affiliations
  1. Shenzhen Institute of Advanced Technology
  2. The University of Hong Kong
  3. Hong Kong University of Science and Technology
  4. Capital Medical University China