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Article: Diagnostic value of nonlinear optical signals from collagen matrix in the detection of epithelial precancer

TitleDiagnostic value of nonlinear optical signals from collagen matrix in the detection of epithelial precancer
Authors
Issue Date2011
PublisherOptical Society of America. The Journal's web site is located at http://www.opticsinfobase.org/current.cfm?journal=3
Citation
Optics Letters, 2011, v. 36 n. 18, p. 3620-3622 How to Cite?
Abstract
During precancer development in epithelium, neoplastic cells remodel the underlying stroma, for example, the basement membrane, capillaries, fibroblasts, and extracellular matrix. The purpose of this study is to investigate the relationship between the nonlinear optical signals from the collagen matrix in stroma and the progression of early epithelial carcinogenesis. Two-photon excited fluorescence (TPEF) and second harmonic generation (SHG) signals were measured from the stroma of hamster oral cheek pouch in vivo. We found that three features, including the intensity ratio of TPEF over SHG, the spatial frequency distribution, and the texture feature of SHG images, provide the quantitative identification of epithelial precancer at different pathologic stages. We demonstrated that the combination of all three features by using a support vector machine algorithm can significantly improve the accuracy in the detection of epithelial precancer.
Persistent Identifierhttp://hdl.handle.net/10722/154678
ISSN
2013 Impact Factor: 3.179
References

 

Author Affiliations
  1. Shenzhen Institute of Advanced Technology
  2. The University of Hong Kong
  3. Hong Kong University of Science and Technology
  4. Capital Medical University China
DC FieldValueLanguage
dc.contributor.authorZheng, Wen_US
dc.contributor.authorLi, Den_US
dc.contributor.authorLi, Sen_US
dc.contributor.authorZeng, Yen_US
dc.contributor.authorYang, Yen_US
dc.contributor.authorQu, JYen_US
dc.date.accessioned2012-08-08T08:26:52Z-
dc.date.available2012-08-08T08:26:52Z-
dc.date.issued2011en_US
dc.identifier.citationOptics Letters, 2011, v. 36 n. 18, p. 3620-3622en_US
dc.identifier.issn0146-9592en_US
dc.identifier.urihttp://hdl.handle.net/10722/154678-
dc.description.abstractDuring precancer development in epithelium, neoplastic cells remodel the underlying stroma, for example, the basement membrane, capillaries, fibroblasts, and extracellular matrix. The purpose of this study is to investigate the relationship between the nonlinear optical signals from the collagen matrix in stroma and the progression of early epithelial carcinogenesis. Two-photon excited fluorescence (TPEF) and second harmonic generation (SHG) signals were measured from the stroma of hamster oral cheek pouch in vivo. We found that three features, including the intensity ratio of TPEF over SHG, the spatial frequency distribution, and the texture feature of SHG images, provide the quantitative identification of epithelial precancer at different pathologic stages. We demonstrated that the combination of all three features by using a support vector machine algorithm can significantly improve the accuracy in the detection of epithelial precancer.en_US
dc.languageengen_US
dc.publisherOptical Society of America. The Journal's web site is located at http://www.opticsinfobase.org/current.cfm?journal=3en_US
dc.relation.ispartofOptics Lettersen_US
dc.rightsThis paper was published in [Optics Letters] and is made available as an electronic reprint with the permission of OSA. The paper can be found at the following URL on the OSA website: [http://www.opticsinfobase.org/ol/abstract.cfm?uri=ol-36-18-3620]. Systematic or multiple reproduction or distribution to multiple locations via electronic or other means is prohibited and is subject to penalties under law.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshCollagen - metabolism-
dc.subject.meshNeoplasms, Glandular and Epithelial - diagnosis - metabolism - pathology-
dc.subject.meshNonlinear Dynamics-
dc.subject.meshOptical Processes-
dc.subject.meshPrecancerous Conditions - diagnosis - metabolism - pathology-
dc.titleDiagnostic value of nonlinear optical signals from collagen matrix in the detection of epithelial precanceren_US
dc.typeArticleen_US
dc.identifier.emailYang, Y: yangyanq@hkucc.hku.hken_US
dc.identifier.emailQu, JY: eequ@ust.hk-
dc.identifier.authorityYang, Y=rp00045en_US
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1364/OL.36.003620en_US
dc.identifier.pmid21931410-
dc.identifier.scopuseid_2-s2.0-80052952921en_US
dc.identifier.hkuros206870-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80052952921&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume36en_US
dc.identifier.issue18en_US
dc.identifier.spage3620en_US
dc.identifier.epage3622en_US
dc.identifier.eissn1539-4794-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridQu, JY=7201534954en_US
dc.identifier.scopusauthoridYang, Y=36623085300en_US
dc.identifier.scopusauthoridZeng, Y=36774006000en_US
dc.identifier.scopusauthoridLi, S=52463882000en_US
dc.identifier.scopusauthoridLi, D=36068588000en_US
dc.identifier.scopusauthoridZheng, W=35373761000en_US

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