Article: Diagnostic value of nonlinear optical signals from collagen matrix in the detection of epithelial precancer

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TitleDiagnostic value of nonlinear optical signals from collagen matrix in the detection of epithelial precancer
AuthorsZheng, W1 3
Li, D3
Li, S2 4
Zeng, Y3
Yang, Y2
Qu, JY3
Issue Date2011
PublisherOptical Society of America. The Journal's web site is located at http://www.opticsinfobase.org/current.cfm?journal=3
CitationOptics Letters, 2011, v. 36 n. 18, p. 3620-3622 [How to Cite?]
DOI: http://dx.doi.org/10.1364/OL.36.003620
AbstractDuring precancer development in epithelium, neoplastic cells remodel the underlying stroma, for example, the basement membrane, capillaries, fibroblasts, and extracellular matrix. The purpose of this study is to investigate the relationship between the nonlinear optical signals from the collagen matrix in stroma and the progression of early epithelial carcinogenesis. Two-photon excited fluorescence (TPEF) and second harmonic generation (SHG) signals were measured from the stroma of hamster oral cheek pouch in vivo. We found that three features, including the intensity ratio of TPEF over SHG, the spatial frequency distribution, and the texture feature of SHG images, provide the quantitative identification of epithelial precancer at different pathologic stages. We demonstrated that the combination of all three features by using a support vector machine algorithm can significantly improve the accuracy in the detection of epithelial precancer.
ISSN0146-9592
2011 Impact Factor: 3.399
2011 SCImago Journal Rankings: 2.571
DOIhttp://dx.doi.org/10.1364/OL.36.003620
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorZheng, W
dc.contributor.authorLi, D
dc.contributor.authorLi, S
dc.contributor.authorZeng, Y
dc.contributor.authorYang, Y
dc.contributor.authorQu, JY
dc.date.accessioned2012-08-08T08:26:52Z
dc.date.available2012-08-08T08:26:52Z
dc.date.issued2011
dc.description.abstractDuring precancer development in epithelium, neoplastic cells remodel the underlying stroma, for example, the basement membrane, capillaries, fibroblasts, and extracellular matrix. The purpose of this study is to investigate the relationship between the nonlinear optical signals from the collagen matrix in stroma and the progression of early epithelial carcinogenesis. Two-photon excited fluorescence (TPEF) and second harmonic generation (SHG) signals were measured from the stroma of hamster oral cheek pouch in vivo. We found that three features, including the intensity ratio of TPEF over SHG, the spatial frequency distribution, and the texture feature of SHG images, provide the quantitative identification of epithelial precancer at different pathologic stages. We demonstrated that the combination of all three features by using a support vector machine algorithm can significantly improve the accuracy in the detection of epithelial precancer.
dc.description.naturepublished_or_final_version
dc.identifier.citationOptics Letters, 2011, v. 36 n. 18, p. 3620-3622 [How to Cite?]
DOI: http://dx.doi.org/10.1364/OL.36.003620
dc.identifier.doihttp://dx.doi.org/10.1364/OL.36.003620
dc.identifier.epage3622
dc.identifier.hkuros206870
dc.identifier.issn0146-9592
2011 Impact Factor: 3.399
2011 SCImago Journal Rankings: 2.571
dc.identifier.issue18
dc.identifier.pmid21931410
dc.identifier.scopuseid_2-s2.0-80052952921
dc.identifier.spage3620
dc.identifier.urihttp://hdl.handle.net/10722/154678
dc.identifier.volume36
dc.languageeng
dc.publisherOptical Society of America. The Journal's web site is located at http://www.opticsinfobase.org/current.cfm?journal=3
dc.publisher.placeUnited States
dc.relation.ispartofOptics Letters
dc.relation.referencesReferences in Scopus
dc.rightsThis paper was published in [Optics Letters] and is made available as an electronic reprint with the permission of OSA. The paper can be found at the following URL on the OSA website: [http://www.opticsinfobase.org/ol/abstract.cfm?uri=ol-36-18-3620]. Systematic or multiple reproduction or distribution to multiple locations via electronic or other means is prohibited and is subject to penalties under law.
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
dc.subject.meshCollagen - metabolism
dc.subject.meshNeoplasms, Glandular and Epithelial - diagnosis - metabolism - pathology
dc.subject.meshNonlinear Dynamics
dc.subject.meshOptical Processes
dc.subject.meshPrecancerous Conditions - diagnosis - metabolism - pathology
dc.titleDiagnostic value of nonlinear optical signals from collagen matrix in the detection of epithelial precancer
dc.typeArticle
Author Affiliations
  1. Shenzhen Institute of Advanced Technology
  2. The University of Hong Kong
  3. Hong Kong University of Science and Technology
  4. Capital Medical University China