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Article: Salivary Epstein-Barr virus DNA level in patients with nasopharyngeal carcinoma following radiotherapy

TitleSalivary Epstein-Barr virus DNA level in patients with nasopharyngeal carcinoma following radiotherapy
Authors
Issue Date2011
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/oraloncology
Citation
Oral Oncology, 2011, v. 47 n. 9, p. 879-882 How to Cite?
AbstractNasopharyngeal carcinoma (NPC) is a solid tumor closely associated with Epstein-Barr virus (EBV) infection. The purpose of this investigation was to detect and quantify the EBV DNA level in salivary samples of NPC patients following treatment using real-time PCR. A total of 175 consecutive newly diagnosed NPC patients' whole saliva samples were collected before treatment, and the EBV DNA level was measured by real-time PCR, with the primers and probe targeting the BamHI-W region of the EBV genome. The post-treatment salivary EBV DNA level was also assessed in 46 patients. The change of EBV DNA level before and after treatment and relationship of EBV DNA level to demographic data and tumor staging were tested by Wilcoxon signed-rank test and Mann-Whitney U test, respectively with the level of significance set at 0.05. The EBV detection rate of pre-treatment saliva samples was 80%. The EBV DNA level of post-treatment saliva samples was significantly higher than the pre-treatment ones (P < 0.01). There is a trend that patients with advanced-stage showed a higher EBV DNA level than patients with early-stage. The detection of EBV DNA in saliva using real-time PCR might be a feasible and non-invasive method for early diagnosis of NPC. © 2010 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/154674
ISSN
2015 Impact Factor: 4.286
2015 SCImago Journal Rankings: 1.764
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPow, EHNen_US
dc.contributor.authorLaw, MYTen_US
dc.contributor.authorTsang, PCSen_US
dc.contributor.authorPerera, RAPMen_US
dc.contributor.authorKwong, DLWen_US
dc.date.accessioned2012-08-08T08:26:51Z-
dc.date.available2012-08-08T08:26:51Z-
dc.date.issued2011en_US
dc.identifier.citationOral Oncology, 2011, v. 47 n. 9, p. 879-882en_US
dc.identifier.issn1368-8375en_US
dc.identifier.urihttp://hdl.handle.net/10722/154674-
dc.description.abstractNasopharyngeal carcinoma (NPC) is a solid tumor closely associated with Epstein-Barr virus (EBV) infection. The purpose of this investigation was to detect and quantify the EBV DNA level in salivary samples of NPC patients following treatment using real-time PCR. A total of 175 consecutive newly diagnosed NPC patients' whole saliva samples were collected before treatment, and the EBV DNA level was measured by real-time PCR, with the primers and probe targeting the BamHI-W region of the EBV genome. The post-treatment salivary EBV DNA level was also assessed in 46 patients. The change of EBV DNA level before and after treatment and relationship of EBV DNA level to demographic data and tumor staging were tested by Wilcoxon signed-rank test and Mann-Whitney U test, respectively with the level of significance set at 0.05. The EBV detection rate of pre-treatment saliva samples was 80%. The EBV DNA level of post-treatment saliva samples was significantly higher than the pre-treatment ones (P < 0.01). There is a trend that patients with advanced-stage showed a higher EBV DNA level than patients with early-stage. The detection of EBV DNA in saliva using real-time PCR might be a feasible and non-invasive method for early diagnosis of NPC. © 2010 Elsevier Ltd. All rights reserved.en_US
dc.languageengen_US
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/oraloncologyen_US
dc.relation.ispartofOral Oncologyen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshDna, Viral - Isolation & Purificationen_US
dc.subject.meshFemaleen_US
dc.subject.meshHerpesvirus 4, Human - Isolation & Purificationen_US
dc.subject.meshHong Kongen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNasopharyngeal Neoplasms - Diagnosis - Radiotherapy - Virologyen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshSaliva - Chemistryen_US
dc.subject.meshYoung Adulten_US
dc.titleSalivary Epstein-Barr virus DNA level in patients with nasopharyngeal carcinoma following radiotherapyen_US
dc.typeArticleen_US
dc.identifier.emailPow, EHN:ehnpow@hku.hken_US
dc.identifier.emailKwong, DLW:dlwkwong@hku.hken_US
dc.identifier.authorityPow, EHN=rp00030en_US
dc.identifier.authorityKwong, DLW=rp00414en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.oraloncology.2011.06.507en_US
dc.identifier.pmid21767975-
dc.identifier.scopuseid_2-s2.0-80052270971en_US
dc.identifier.hkuros197573-
dc.identifier.hkuros217043-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80052270971&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume47en_US
dc.identifier.issue9en_US
dc.identifier.spage879en_US
dc.identifier.epage882en_US
dc.identifier.eissn1879-0593-
dc.identifier.isiWOS:000294299600017-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridPow, EHN=6603825799en_US
dc.identifier.scopusauthoridLaw, MYT=54393251500en_US
dc.identifier.scopusauthoridTsang, PCS=54394585000en_US
dc.identifier.scopusauthoridPerera, RAPM=43861730800en_US
dc.identifier.scopusauthoridKwong, DLW=15744231600en_US
dc.identifier.citeulike9631416-

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