Article: Analysis of genetic polymorphisms in skeletal Class i crowding

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TitleAnalysis of genetic polymorphisms in skeletal Class i crowding
AuthorsTing, TY1
Wong, RWK1
Rabie, ABM1
Issue Date2011
PublisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/ajodo
CitationAmerican Journal Of Orthodontics And Dentofacial Orthopedics, 2011, v. 140 n. 1, p. e9-e15 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.ajodo.2010.12.015
AbstractIntroduction: Dental crowding is a problem for both adolescents and adults in modern society. The purpose of this research was to identify single nucleotide polymorphisms (SNPs) responsible for crowding in subjects with skeletal Class I relationships. Methods: The case subjects consisted of healthy Chinese people living in Hong Kong with skeletal Class I relationships and at least 5 mm of crowding in either arch. The control subjects met the same requirements but lacked crowding or spacing. SNP genotyping was performed on the MassARRAY platform. The chi-square test was used to compare genotype and allele type distributions between the case and the control groups. Logistic regression was used to calculate odds ratios with 95% confidence intervals, and the effects of age and sex for each SNP. Analyses of linkage disequilibrium and haplotype associations between SNPs were performed with software. Results: Five SNPs were found to be significantly different in genotype or allele type distributions. SNP rs372024 was significantly associated with crowding (P = 0.004). Two SNPs, rs3764746 and rs3795170, on the EDA gene were found to be associated marginally. SNPs rs1005464 and rs15705 also exhibited marginal association with crowding. The effects of associated SNPs remained significant after adjustments for age and sex factors. Conclusions: This study suggests an association for the genes EDA and XEDAR in dental crowding in the Hong Kong Chinese population. Copyright © 2011 by the American Association of Orthodontists.
ISSN0889-5406
2011 Impact Factor: 1.381
2011 SCImago Journal Rankings: 0.062
DOIhttp://dx.doi.org/10.1016/j.ajodo.2010.12.015
ISI Accession Number IDWOS:000292304100002
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorTing, TY
dc.contributor.authorWong, RWK
dc.contributor.authorRabie, ABM
dc.date.accessioned2012-08-08T08:26:50Z
dc.date.available2012-08-08T08:26:50Z
dc.date.issued2011
dc.description.abstractIntroduction: Dental crowding is a problem for both adolescents and adults in modern society. The purpose of this research was to identify single nucleotide polymorphisms (SNPs) responsible for crowding in subjects with skeletal Class I relationships. Methods: The case subjects consisted of healthy Chinese people living in Hong Kong with skeletal Class I relationships and at least 5 mm of crowding in either arch. The control subjects met the same requirements but lacked crowding or spacing. SNP genotyping was performed on the MassARRAY platform. The chi-square test was used to compare genotype and allele type distributions between the case and the control groups. Logistic regression was used to calculate odds ratios with 95% confidence intervals, and the effects of age and sex for each SNP. Analyses of linkage disequilibrium and haplotype associations between SNPs were performed with software. Results: Five SNPs were found to be significantly different in genotype or allele type distributions. SNP rs372024 was significantly associated with crowding (P = 0.004). Two SNPs, rs3764746 and rs3795170, on the EDA gene were found to be associated marginally. SNPs rs1005464 and rs15705 also exhibited marginal association with crowding. The effects of associated SNPs remained significant after adjustments for age and sex factors. Conclusions: This study suggests an association for the genes EDA and XEDAR in dental crowding in the Hong Kong Chinese population. Copyright © 2011 by the American Association of Orthodontists.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationAmerican Journal Of Orthodontics And Dentofacial Orthopedics, 2011, v. 140 n. 1, p. e9-e15 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.ajodo.2010.12.015
dc.identifier.doihttp://dx.doi.org/10.1016/j.ajodo.2010.12.015
dc.identifier.epagee15
dc.identifier.hkuros195745
dc.identifier.isiWOS:000292304100002
dc.identifier.issn0889-5406
2011 Impact Factor: 1.381
2011 SCImago Journal Rankings: 0.062
dc.identifier.issue1
dc.identifier.pmid21724072
dc.identifier.scopuseid_2-s2.0-79959925202
dc.identifier.spagee9
dc.identifier.urihttp://hdl.handle.net/10722/154670
dc.identifier.volume140
dc.languageeng
dc.publisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/ajodo
dc.publisher.placeUnited States
dc.relation.ispartofAmerican Journal of Orthodontics and Dentofacial Orthopedics
dc.relation.referencesReferences in Scopus
dc.subject.meshAdolescent
dc.subject.meshAsian Continental Ancestry Group - Genetics
dc.subject.meshCase-Control Studies
dc.subject.meshChi-Square Distribution
dc.subject.meshDna Mutational Analysis - Methods
dc.subject.meshEctodysplasins - Genetics
dc.subject.meshFemale
dc.subject.meshGene Frequency
dc.subject.meshHong Kong
dc.subject.meshHumans
dc.subject.meshLinkage Disequilibrium
dc.subject.meshLogistic Models
dc.subject.meshMale
dc.subject.meshMalocclusion, Angle Class I - Genetics
dc.subject.meshMass Spectrometry - Methods
dc.subject.meshOligonucleotide Array Sequence Analysis - Methods
dc.subject.meshPolymorphism, Single Nucleotide
dc.subject.meshXedar Receptor - Genetics
dc.titleAnalysis of genetic polymorphisms in skeletal Class i crowding
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong