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Article: Analysis of genetic polymorphisms in skeletal Class i crowding

TitleAnalysis of genetic polymorphisms in skeletal Class i crowding
Authors
Issue Date2011
PublisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/ajodo
Citation
American Journal Of Orthodontics And Dentofacial Orthopedics, 2011, v. 140 n. 1, p. e9-e15 How to Cite?
AbstractIntroduction: Dental crowding is a problem for both adolescents and adults in modern society. The purpose of this research was to identify single nucleotide polymorphisms (SNPs) responsible for crowding in subjects with skeletal Class I relationships. Methods: The case subjects consisted of healthy Chinese people living in Hong Kong with skeletal Class I relationships and at least 5 mm of crowding in either arch. The control subjects met the same requirements but lacked crowding or spacing. SNP genotyping was performed on the MassARRAY platform. The chi-square test was used to compare genotype and allele type distributions between the case and the control groups. Logistic regression was used to calculate odds ratios with 95% confidence intervals, and the effects of age and sex for each SNP. Analyses of linkage disequilibrium and haplotype associations between SNPs were performed with software. Results: Five SNPs were found to be significantly different in genotype or allele type distributions. SNP rs372024 was significantly associated with crowding (P = 0.004). Two SNPs, rs3764746 and rs3795170, on the EDA gene were found to be associated marginally. SNPs rs1005464 and rs15705 also exhibited marginal association with crowding. The effects of associated SNPs remained significant after adjustments for age and sex factors. Conclusions: This study suggests an association for the genes EDA and XEDAR in dental crowding in the Hong Kong Chinese population. Copyright © 2011 by the American Association of Orthodontists.
Persistent Identifierhttp://hdl.handle.net/10722/154670
ISSN
2014 Impact Factor: 1.382
2014 SCImago Journal Rankings: 1.046
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTing, TYen_US
dc.contributor.authorWong, RWKen_US
dc.contributor.authorRabie, ABMen_US
dc.date.accessioned2012-08-08T08:26:50Z-
dc.date.available2012-08-08T08:26:50Z-
dc.date.issued2011en_US
dc.identifier.citationAmerican Journal Of Orthodontics And Dentofacial Orthopedics, 2011, v. 140 n. 1, p. e9-e15en_US
dc.identifier.issn0889-5406en_US
dc.identifier.urihttp://hdl.handle.net/10722/154670-
dc.description.abstractIntroduction: Dental crowding is a problem for both adolescents and adults in modern society. The purpose of this research was to identify single nucleotide polymorphisms (SNPs) responsible for crowding in subjects with skeletal Class I relationships. Methods: The case subjects consisted of healthy Chinese people living in Hong Kong with skeletal Class I relationships and at least 5 mm of crowding in either arch. The control subjects met the same requirements but lacked crowding or spacing. SNP genotyping was performed on the MassARRAY platform. The chi-square test was used to compare genotype and allele type distributions between the case and the control groups. Logistic regression was used to calculate odds ratios with 95% confidence intervals, and the effects of age and sex for each SNP. Analyses of linkage disequilibrium and haplotype associations between SNPs were performed with software. Results: Five SNPs were found to be significantly different in genotype or allele type distributions. SNP rs372024 was significantly associated with crowding (P = 0.004). Two SNPs, rs3764746 and rs3795170, on the EDA gene were found to be associated marginally. SNPs rs1005464 and rs15705 also exhibited marginal association with crowding. The effects of associated SNPs remained significant after adjustments for age and sex factors. Conclusions: This study suggests an association for the genes EDA and XEDAR in dental crowding in the Hong Kong Chinese population. Copyright © 2011 by the American Association of Orthodontists.en_US
dc.languageengen_US
dc.publisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/ajodoen_US
dc.relation.ispartofAmerican Journal of Orthodontics and Dentofacial Orthopedicsen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAsian Continental Ancestry Group - Geneticsen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshChi-Square Distributionen_US
dc.subject.meshDna Mutational Analysis - Methodsen_US
dc.subject.meshEctodysplasins - Geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Frequencyen_US
dc.subject.meshHong Kongen_US
dc.subject.meshHumansen_US
dc.subject.meshLinkage Disequilibriumen_US
dc.subject.meshLogistic Modelsen_US
dc.subject.meshMaleen_US
dc.subject.meshMalocclusion, Angle Class I - Geneticsen_US
dc.subject.meshMass Spectrometry - Methodsen_US
dc.subject.meshOligonucleotide Array Sequence Analysis - Methodsen_US
dc.subject.meshPolymorphism, Single Nucleotideen_US
dc.subject.meshXedar Receptor - Geneticsen_US
dc.titleAnalysis of genetic polymorphisms in skeletal Class i crowdingen_US
dc.typeArticleen_US
dc.identifier.emailRabie, ABM:rabie@hku.hken_US
dc.identifier.authorityRabie, ABM=rp00029en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.ajodo.2010.12.015en_US
dc.identifier.pmid21724072-
dc.identifier.scopuseid_2-s2.0-79959925202en_US
dc.identifier.hkuros195745-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79959925202&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume140en_US
dc.identifier.issue1en_US
dc.identifier.spagee9en_US
dc.identifier.epagee15en_US
dc.identifier.isiWOS:000292304100002-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridTing, TY=50162501000en_US
dc.identifier.scopusauthoridWong, RWK=36642905800en_US
dc.identifier.scopusauthoridRabie, ABM=7007172734en_US

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