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Article: Neuroprotective effect of preadministration with Ganoderma lucidum spore on rat hippocampus
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TitleNeuroprotective effect of preadministration with Ganoderma lucidum spore on rat hippocampus
 
AuthorsZhou, Y3
Qu, Zq3
Zeng, Ys3
Lin, Yk3
Li, Y3
Chung, P2
Wong, R1
Hägg, U1
 
KeywordsAlzheimer's Disease
Ganoderma Lucidum
Intracerebroventricular Streptozotocin
Learning And Memory
Neuroprotective Effect
Oxidative Stress
 
Issue Date2012
 
PublisherUrban und Fischer Verlag. The Journal's web site is located at http://www.elsevier.com/locate/exptoxpath
 
CitationExperimental And Toxicologic Pathology, 2012, v. 64 n. 7-8, p. 673-680 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.etp.2010.12.011
 
AbstractThe aim of this study was to investigate if preadministration with Ganoderma lucidum spore (GLS) could (1) alleviate oxidative stress and mitochondrial dysfunction in rat hippocampus of intracerebroventricular (ICV) injection of streptozotocin (STZ), (2) protect neurons from apoptosis, and (3) improve cognitive dysfunction. Three groups of Sprague-Dawley rats were preadministrated with GLS at doses of 2.0, 4.0 and 8.0 g/kg, respectively, for 3 weeks before the ICV STZ injury. Thereafter the rats were operated with ICV STZ (1.5 mg/kg) bilaterally on days 1 and 3. The behavioral alterations, oxidative stress indexes, ATP, cytochrome oxidase (CytOx), and histopathology of hippocampal neurons were studied. The results showed that ICV STZ model rats exhibited a significant increase of malondialdehyde (MDA), a significant decrease of glutathione reductase (GR), reduced glutathione (GSH), ATP and CytOx, accompanied with marked impairments in spatial learning and memory, and severe damage of hippocampal neuron. In conclusion, preadministration with GLS at dose of 8.0 g/kg in ICV STZ rats significantly reversed these abnormalities. In conclusion, preadministration with GLS might protect hippocampus from oxidative impairment and energy metabolism disturbance of ICV STZ. This may also provide useful information for future research on the pathogenesis and prevention of Alzheimer's disease (AD). © 2011.
 
ISSN0940-2993
2012 Impact Factor: 2.622
2012 SCImago Journal Rankings: 0.622
 
DOIhttp://dx.doi.org/10.1016/j.etp.2010.12.011
 
DC FieldValue
dc.contributor.authorZhou, Y
 
dc.contributor.authorQu, Zq
 
dc.contributor.authorZeng, Ys
 
dc.contributor.authorLin, Yk
 
dc.contributor.authorLi, Y
 
dc.contributor.authorChung, P
 
dc.contributor.authorWong, R
 
dc.contributor.authorHägg, U
 
dc.date.accessioned2012-08-08T08:26:44Z
 
dc.date.available2012-08-08T08:26:44Z
 
dc.date.issued2012
 
dc.description.abstractThe aim of this study was to investigate if preadministration with Ganoderma lucidum spore (GLS) could (1) alleviate oxidative stress and mitochondrial dysfunction in rat hippocampus of intracerebroventricular (ICV) injection of streptozotocin (STZ), (2) protect neurons from apoptosis, and (3) improve cognitive dysfunction. Three groups of Sprague-Dawley rats were preadministrated with GLS at doses of 2.0, 4.0 and 8.0 g/kg, respectively, for 3 weeks before the ICV STZ injury. Thereafter the rats were operated with ICV STZ (1.5 mg/kg) bilaterally on days 1 and 3. The behavioral alterations, oxidative stress indexes, ATP, cytochrome oxidase (CytOx), and histopathology of hippocampal neurons were studied. The results showed that ICV STZ model rats exhibited a significant increase of malondialdehyde (MDA), a significant decrease of glutathione reductase (GR), reduced glutathione (GSH), ATP and CytOx, accompanied with marked impairments in spatial learning and memory, and severe damage of hippocampal neuron. In conclusion, preadministration with GLS at dose of 8.0 g/kg in ICV STZ rats significantly reversed these abnormalities. In conclusion, preadministration with GLS might protect hippocampus from oxidative impairment and energy metabolism disturbance of ICV STZ. This may also provide useful information for future research on the pathogenesis and prevention of Alzheimer's disease (AD). © 2011.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationExperimental And Toxicologic Pathology, 2012, v. 64 n. 7-8, p. 673-680 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.etp.2010.12.011
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.etp.2010.12.011
 
dc.identifier.hkuros215081
 
dc.identifier.issn0940-2993
2012 Impact Factor: 2.622
2012 SCImago Journal Rankings: 0.622
 
dc.identifier.pmid21242065
 
dc.identifier.scopuseid_2-s2.0-84867702952
 
dc.identifier.urihttp://hdl.handle.net/10722/154654
 
dc.languageeng
 
dc.publisherUrban und Fischer Verlag. The Journal's web site is located at http://www.elsevier.com/locate/exptoxpath
 
dc.publisher.placeGermany
 
dc.relation.ispartofExperimental and Toxicologic Pathology
 
dc.subjectAlzheimer's Disease
 
dc.subjectGanoderma Lucidum
 
dc.subjectIntracerebroventricular Streptozotocin
 
dc.subjectLearning And Memory
 
dc.subjectNeuroprotective Effect
 
dc.subjectOxidative Stress
 
dc.titleNeuroprotective effect of preadministration with Ganoderma lucidum spore on rat hippocampus
 
dc.typeArticle
 
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<item><contributor.author>Zhou, Y</contributor.author>
<contributor.author>Qu, Zq</contributor.author>
<contributor.author>Zeng, Ys</contributor.author>
<contributor.author>Lin, Yk</contributor.author>
<contributor.author>Li, Y</contributor.author>
<contributor.author>Chung, P</contributor.author>
<contributor.author>Wong, R</contributor.author>
<contributor.author>H&#228;gg, U</contributor.author>
<date.accessioned>2012-08-08T08:26:44Z</date.accessioned>
<date.available>2012-08-08T08:26:44Z</date.available>
<date.issued>2012</date.issued>
<identifier.citation>Experimental And Toxicologic Pathology, 2012, v. 64 n. 7-8, p. 673-680</identifier.citation>
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<description.abstract>The aim of this study was to investigate if preadministration with Ganoderma lucidum spore (GLS) could (1) alleviate oxidative stress and mitochondrial dysfunction in rat hippocampus of intracerebroventricular (ICV) injection of streptozotocin (STZ), (2) protect neurons from apoptosis, and (3) improve cognitive dysfunction. Three groups of Sprague-Dawley rats were preadministrated with GLS at doses of 2.0, 4.0 and 8.0 g/kg, respectively, for 3 weeks before the ICV STZ injury. Thereafter the rats were operated with ICV STZ (1.5 mg/kg) bilaterally on days 1 and 3. The behavioral alterations, oxidative stress indexes, ATP, cytochrome oxidase (CytOx), and histopathology of hippocampal neurons were studied. The results showed that ICV STZ model rats exhibited a significant increase of malondialdehyde (MDA), a significant decrease of glutathione reductase (GR), reduced glutathione (GSH), ATP and CytOx, accompanied with marked impairments in spatial learning and memory, and severe damage of hippocampal neuron. In conclusion, preadministration with GLS at dose of 8.0 g/kg in ICV STZ rats significantly reversed these abnormalities. In conclusion, preadministration with GLS might protect hippocampus from oxidative impairment and energy metabolism disturbance of ICV STZ. This may also provide useful information for future research on the pathogenesis and prevention of Alzheimer&apos;s disease (AD). &#169; 2011.</description.abstract>
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<subject>Alzheimer&apos;s Disease</subject>
<subject>Ganoderma Lucidum</subject>
<subject>Intracerebroventricular Streptozotocin</subject>
<subject>Learning And Memory</subject>
<subject>Neuroprotective Effect</subject>
<subject>Oxidative Stress</subject>
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Author Affiliations
  1. The University of Hong Kong
  2. null
  3. Sun Yat-Sen University