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Article: Neuroprotective effect of preadministration with Ganoderma lucidum spore on rat hippocampus

TitleNeuroprotective effect of preadministration with Ganoderma lucidum spore on rat hippocampus
Authors
KeywordsAlzheimer's Disease
Ganoderma Lucidum
Intracerebroventricular Streptozotocin
Learning And Memory
Neuroprotective Effect
Oxidative Stress
Issue Date2012
PublisherUrban und Fischer Verlag. The Journal's web site is located at http://www.elsevier.com/locate/exptoxpath
Citation
Experimental And Toxicologic Pathology, 2012, v. 64 n. 7-8, p. 673-680 How to Cite?
AbstractThe aim of this study was to investigate if preadministration with Ganoderma lucidum spore (GLS) could (1) alleviate oxidative stress and mitochondrial dysfunction in rat hippocampus of intracerebroventricular (ICV) injection of streptozotocin (STZ), (2) protect neurons from apoptosis, and (3) improve cognitive dysfunction. Three groups of Sprague-Dawley rats were preadministrated with GLS at doses of 2.0, 4.0 and 8.0 g/kg, respectively, for 3 weeks before the ICV STZ injury. Thereafter the rats were operated with ICV STZ (1.5 mg/kg) bilaterally on days 1 and 3. The behavioral alterations, oxidative stress indexes, ATP, cytochrome oxidase (CytOx), and histopathology of hippocampal neurons were studied. The results showed that ICV STZ model rats exhibited a significant increase of malondialdehyde (MDA), a significant decrease of glutathione reductase (GR), reduced glutathione (GSH), ATP and CytOx, accompanied with marked impairments in spatial learning and memory, and severe damage of hippocampal neuron. In conclusion, preadministration with GLS at dose of 8.0 g/kg in ICV STZ rats significantly reversed these abnormalities. In conclusion, preadministration with GLS might protect hippocampus from oxidative impairment and energy metabolism disturbance of ICV STZ. This may also provide useful information for future research on the pathogenesis and prevention of Alzheimer's disease (AD). © 2011.
Persistent Identifierhttp://hdl.handle.net/10722/154654
ISSN
2014 Impact Factor: 1.860
2013 SCImago Journal Rankings: 0.694
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhou, Yen_US
dc.contributor.authorQu, Zqen_US
dc.contributor.authorZeng, Ysen_US
dc.contributor.authorLin, Yken_US
dc.contributor.authorLi, Yen_US
dc.contributor.authorChung, Pen_US
dc.contributor.authorWong, Ren_US
dc.contributor.authorHägg, Uen_US
dc.date.accessioned2012-08-08T08:26:44Z-
dc.date.available2012-08-08T08:26:44Z-
dc.date.issued2012en_US
dc.identifier.citationExperimental And Toxicologic Pathology, 2012, v. 64 n. 7-8, p. 673-680en_US
dc.identifier.issn0940-2993en_US
dc.identifier.urihttp://hdl.handle.net/10722/154654-
dc.description.abstractThe aim of this study was to investigate if preadministration with Ganoderma lucidum spore (GLS) could (1) alleviate oxidative stress and mitochondrial dysfunction in rat hippocampus of intracerebroventricular (ICV) injection of streptozotocin (STZ), (2) protect neurons from apoptosis, and (3) improve cognitive dysfunction. Three groups of Sprague-Dawley rats were preadministrated with GLS at doses of 2.0, 4.0 and 8.0 g/kg, respectively, for 3 weeks before the ICV STZ injury. Thereafter the rats were operated with ICV STZ (1.5 mg/kg) bilaterally on days 1 and 3. The behavioral alterations, oxidative stress indexes, ATP, cytochrome oxidase (CytOx), and histopathology of hippocampal neurons were studied. The results showed that ICV STZ model rats exhibited a significant increase of malondialdehyde (MDA), a significant decrease of glutathione reductase (GR), reduced glutathione (GSH), ATP and CytOx, accompanied with marked impairments in spatial learning and memory, and severe damage of hippocampal neuron. In conclusion, preadministration with GLS at dose of 8.0 g/kg in ICV STZ rats significantly reversed these abnormalities. In conclusion, preadministration with GLS might protect hippocampus from oxidative impairment and energy metabolism disturbance of ICV STZ. This may also provide useful information for future research on the pathogenesis and prevention of Alzheimer's disease (AD). © 2011.en_US
dc.languageengen_US
dc.publisherUrban und Fischer Verlag. The Journal's web site is located at http://www.elsevier.com/locate/exptoxpathen_US
dc.relation.ispartofExperimental and Toxicologic Pathologyen_US
dc.subjectAlzheimer's Diseaseen_US
dc.subjectGanoderma Lucidumen_US
dc.subjectIntracerebroventricular Streptozotocinen_US
dc.subjectLearning And Memoryen_US
dc.subjectNeuroprotective Effecten_US
dc.subjectOxidative Stressen_US
dc.titleNeuroprotective effect of preadministration with Ganoderma lucidum spore on rat hippocampusen_US
dc.typeArticleen_US
dc.identifier.emailWong, R:fyoung@hkucc.hku.hken_US
dc.identifier.emailHägg, U:euohagg@hkusua.hku.hken_US
dc.identifier.authorityWong, R=rp00038en_US
dc.identifier.authorityHägg, U=rp00020en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.etp.2010.12.011en_US
dc.identifier.pmid21242065-
dc.identifier.scopuseid_2-s2.0-84867702952en_US
dc.identifier.hkuros215081-
dc.identifier.isiWOS:000311073100002-
dc.publisher.placeGermanyen_US
dc.identifier.scopusauthoridZhou, Y=36769909200en_US
dc.identifier.scopusauthoridQu, Zq=14068003100en_US
dc.identifier.scopusauthoridZeng, Ys=8236229300en_US
dc.identifier.scopusauthoridLin, Yk=36768461300en_US
dc.identifier.scopusauthoridLi, Y=36078298200en_US
dc.identifier.scopusauthoridChung, P=35204745900en_US
dc.identifier.scopusauthoridWong, R=7402127170en_US
dc.identifier.scopusauthoridHägg, U=7006790279en_US

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