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Article: A randomized, controlled clinical trial on the clinical, microbiological, and staining effects of a novel 0.05% chlorhexidine/herbal extract and a 0.1% chlorhexidine mouthrinse adjunct to periodontal surgery

TitleA randomized, controlled clinical trial on the clinical, microbiological, and staining effects of a novel 0.05% chlorhexidine/herbal extract and a 0.1% chlorhexidine mouthrinse adjunct to periodontal surgery
Authors
Issue Date2010
PublisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CPE
Citation
Journal Of Clinical Periodontology, 2010, v. 37 n. 11, p. 988-997 How to Cite?
AbstractBackground: Chlorhexidine (CHX) rinsing after periodontal surgery is common. We assessed the clinical and microbiological effects of two CHX concentrations following periodontal surgery. Materials and methods: In a randomized, controlled clinical trial, 45 subjects were assigned to 4 weeks rinsing with a 0.05 CHX/herbal extract combination (test) or a 0.1% CHX solution. Clinical and staining effects were studied. Subgingival bacteria were assessed using the DNA-DNA checkerboard. Statistics included parametric and non-parametric tests (p<0001 to declare significance at 80% power). Results: At weeks 4 and 12, more staining was found in the control group (p<0.05 and p<0.001, respectively). A higher risk for staining was found in the control group (crude OR: 2.3:1, 95% CI: 1.3 to 4.4, p<0.01). The absolute staining reduction in the test group was 21.1% (9 5% CI: 9.4-32.8%). Probing pocket depth (PPD) decreases were significant (p<0.001) in both groups and similar (p=0.92). No rinse group differences in changes of bacterial counts for any species were found between baseline and week 12. Conclusions: The test CHX rinse resulted in less tooth staining. At the study endpoint, similar and high counts of periodontal pathogens were found. © 2010 John Wiley & Sons A/S.
Persistent Identifierhttp://hdl.handle.net/10722/154642
ISSN
2015 Impact Factor: 3.915
2015 SCImago Journal Rankings: 1.848
ISI Accession Number ID
Funding AgencyGrant Number
Tentan AG, Switzerland
Clinical Research Foundation (CRF) for the Promotion of Oral Health, Brienz, Switzerland
Funding Information:

The present study was partly funded by a grant from Tentan AG, Switzerland, and by the Clinical Research Foundation (CRF) for the Promotion of Oral Health, CH-3855 Brienz, Switzerland.

References

 

DC FieldValueLanguage
dc.contributor.authorDuss, Cen_US
dc.contributor.authorLang, NPen_US
dc.contributor.authorCosyn, Jen_US
dc.contributor.authorPersson, GRen_US
dc.date.accessioned2012-08-08T08:26:40Z-
dc.date.available2012-08-08T08:26:40Z-
dc.date.issued2010en_US
dc.identifier.citationJournal Of Clinical Periodontology, 2010, v. 37 n. 11, p. 988-997en_US
dc.identifier.issn0303-6979en_US
dc.identifier.urihttp://hdl.handle.net/10722/154642-
dc.description.abstractBackground: Chlorhexidine (CHX) rinsing after periodontal surgery is common. We assessed the clinical and microbiological effects of two CHX concentrations following periodontal surgery. Materials and methods: In a randomized, controlled clinical trial, 45 subjects were assigned to 4 weeks rinsing with a 0.05 CHX/herbal extract combination (test) or a 0.1% CHX solution. Clinical and staining effects were studied. Subgingival bacteria were assessed using the DNA-DNA checkerboard. Statistics included parametric and non-parametric tests (p<0001 to declare significance at 80% power). Results: At weeks 4 and 12, more staining was found in the control group (p<0.05 and p<0.001, respectively). A higher risk for staining was found in the control group (crude OR: 2.3:1, 95% CI: 1.3 to 4.4, p<0.01). The absolute staining reduction in the test group was 21.1% (9 5% CI: 9.4-32.8%). Probing pocket depth (PPD) decreases were significant (p<0.001) in both groups and similar (p=0.92). No rinse group differences in changes of bacterial counts for any species were found between baseline and week 12. Conclusions: The test CHX rinse resulted in less tooth staining. At the study endpoint, similar and high counts of periodontal pathogens were found. © 2010 John Wiley & Sons A/S.en_US
dc.languageengen_US
dc.publisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CPEen_US
dc.relation.ispartofJournal of Clinical Periodontologyen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAnti-Infective Agents, Local - Administration & Dosage - Adverse Effectsen_US
dc.subject.meshBacterial Load - Drug Effectsen_US
dc.subject.meshChlorhexidine - Administration & Dosage - Adverse Effects - Analogs & Derivativesen_US
dc.subject.meshChronic Periodontitis - Drug Therapy - Microbiology - Surgeryen_US
dc.subject.meshColony Count, Microbialen_US
dc.subject.meshDna, Bacterial - Analysisen_US
dc.subject.meshDental Plaque - Microbiologyen_US
dc.subject.meshDouble-Blind Methoden_US
dc.subject.meshDrug Combinationsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLogistic Modelsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMouthwashes - Adverse Effects - Chemistry - Therapeutic Useen_US
dc.subject.meshOdds Ratioen_US
dc.subject.meshPeriodontal Debridementen_US
dc.subject.meshPhytotherapyen_US
dc.subject.meshPlant Oils - Therapeutic Useen_US
dc.subject.meshPlant Preparations - Therapeutic Useen_US
dc.subject.meshSalviaen_US
dc.subject.meshSodium Fluoride - Therapeutic Useen_US
dc.subject.meshStatistics, Nonparametricen_US
dc.subject.meshTerpenes - Therapeutic Useen_US
dc.subject.meshTooth Discoloration - Chemically Induceden_US
dc.titleA randomized, controlled clinical trial on the clinical, microbiological, and staining effects of a novel 0.05% chlorhexidine/herbal extract and a 0.1% chlorhexidine mouthrinse adjunct to periodontal surgeryen_US
dc.typeArticleen_US
dc.identifier.emailLang, NP:nplang@hkucc.hku.hken_US
dc.identifier.authorityLang, NP=rp00031en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1600-051X.2010.01609.xen_US
dc.identifier.pmid20738456-
dc.identifier.scopuseid_2-s2.0-78449264166en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78449264166&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume37en_US
dc.identifier.issue11en_US
dc.identifier.spage988en_US
dc.identifier.epage997en_US
dc.identifier.isiWOS:000283321400006-
dc.publisher.placeDenmarken_US
dc.identifier.scopusauthoridDuss, C=37033745400en_US
dc.identifier.scopusauthoridLang, NP=7201577367en_US
dc.identifier.scopusauthoridCosyn, J=8619615500en_US
dc.identifier.scopusauthoridPersson, GR=7101853867en_US
dc.identifier.citeulike8126674-

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