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Article: Bone Regeneration after Radiotherapy in an Animal Model

TitleBone Regeneration after Radiotherapy in an Animal Model
Authors
Issue Date2010
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/joms
Citation
Journal Of Oral And Maxillofacial Surgery, 2010, v. 68 n. 11, p. 2802-2809 How to Cite?
AbstractPurpose: The study aimed to evaluate dosage-dependent effects of irradiation on bone regeneration and established a radiation-compromised rabbit model of mandibular distraction osteogenesis. Materials and Methods: Twenty-three rabbits were divided randomly into 7 groups. Group A served as the control group, whereas experimental groups B, C, D, E, F, and G received preoperative irradiation at doses of 6.5, 7.0, 7.5, 8.0, 8.5, and 9.0 Gy, respectively, for 5 fractions. After 1 month, all rabbits underwent osteotomy and distraction osteogenesis with 7 days of latency, 11 days of active distraction at a rate of 0.9 mm/d, and 4 weeks of consolidation; rabbit mandibles were subsequently subjected to histologic, radiographic, and microcomputed tomography analysis. Results: With increasing doses of irradiation, bone regeneration was markedly hampered. Radiographically, the high-dose groups (8.5 and 9.0 Gy) presented obscure cortical lines. Histologically, in the 8.5- and 9.0-Gy groups, cortical bones were not completely formed, and in the medullary cavity, there existed a large amount of fibrous tissue. Conclusion: Radiotherapy compromises bone regeneration during distraction osteogenesis, and the adverse effect is dose dependent. © 2010 American Association of Oral and Maxillofacial Surgeons.
Persistent Identifierhttp://hdl.handle.net/10722/154638
ISSN
2015 Impact Factor: 1.631
2015 SCImago Journal Rankings: 0.824
ISI Accession Number ID
Funding AgencyGrant Number
University of Hong Kong
Funding Information:

Supported by funding from The University of Hong Kong.

References

 

DC FieldValueLanguage
dc.contributor.authorZhang, WBen_HK
dc.contributor.authorZheng, LWen_HK
dc.contributor.authorChua, Den_HK
dc.contributor.authorCheung, LKen_HK
dc.date.accessioned2012-08-08T08:26:38Z-
dc.date.available2012-08-08T08:26:38Z-
dc.date.issued2010en_HK
dc.identifier.citationJournal Of Oral And Maxillofacial Surgery, 2010, v. 68 n. 11, p. 2802-2809en_HK
dc.identifier.issn0278-2391en_HK
dc.identifier.urihttp://hdl.handle.net/10722/154638-
dc.description.abstractPurpose: The study aimed to evaluate dosage-dependent effects of irradiation on bone regeneration and established a radiation-compromised rabbit model of mandibular distraction osteogenesis. Materials and Methods: Twenty-three rabbits were divided randomly into 7 groups. Group A served as the control group, whereas experimental groups B, C, D, E, F, and G received preoperative irradiation at doses of 6.5, 7.0, 7.5, 8.0, 8.5, and 9.0 Gy, respectively, for 5 fractions. After 1 month, all rabbits underwent osteotomy and distraction osteogenesis with 7 days of latency, 11 days of active distraction at a rate of 0.9 mm/d, and 4 weeks of consolidation; rabbit mandibles were subsequently subjected to histologic, radiographic, and microcomputed tomography analysis. Results: With increasing doses of irradiation, bone regeneration was markedly hampered. Radiographically, the high-dose groups (8.5 and 9.0 Gy) presented obscure cortical lines. Histologically, in the 8.5- and 9.0-Gy groups, cortical bones were not completely formed, and in the medullary cavity, there existed a large amount of fibrous tissue. Conclusion: Radiotherapy compromises bone regeneration during distraction osteogenesis, and the adverse effect is dose dependent. © 2010 American Association of Oral and Maxillofacial Surgeons.en_HK
dc.languageengen_US
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/jomsen_HK
dc.relation.ispartofJournal of Oral and Maxillofacial Surgeryen_HK
dc.subject.meshAnimalsen_US
dc.subject.meshBone Density - Radiation Effectsen_US
dc.subject.meshBone Marrow - Pathology - Radiation Effectsen_US
dc.subject.meshBone Regeneration - Radiation Effectsen_US
dc.subject.meshBone Remodeling - Radiation Effectsen_US
dc.subject.meshCalcification, Physiologic - Radiation Effectsen_US
dc.subject.meshDose Fractionationen_US
dc.subject.meshDose-Response Relationship, Radiationen_US
dc.subject.meshFemaleen_US
dc.subject.meshMandible - Pathology - Radiation Effects - Surgeryen_US
dc.subject.meshModels, Animalen_US
dc.subject.meshOsteogenesis - Radiation Effectsen_US
dc.subject.meshOsteogenesis, Distractionen_US
dc.subject.meshOsteotomyen_US
dc.subject.meshPreoperative Careen_US
dc.subject.meshRabbitsen_US
dc.subject.meshRadiotherapy Dosageen_US
dc.subject.meshRandom Allocationen_US
dc.subject.meshTime Factorsen_US
dc.subject.meshX-Ray Microtomographyen_US
dc.titleBone Regeneration after Radiotherapy in an Animal Modelen_HK
dc.typeArticleen_HK
dc.identifier.emailZheng, LW: lwzheng@hku.hken_HK
dc.identifier.emailChua, D: dttchua@hkucc.hku.hken_HK
dc.identifier.emailCheung, LK: lkcheung@hkucc.hku.hken_HK
dc.identifier.authorityZheng, LW=rp01411en_HK
dc.identifier.authorityChua, D=rp00415en_HK
dc.identifier.authorityCheung, LK=rp00013en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.joms.2010.04.024en_HK
dc.identifier.pmid20727641-
dc.identifier.scopuseid_2-s2.0-77958616274en_HK
dc.identifier.hkuros170975-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77958616274&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume68en_HK
dc.identifier.issue11en_HK
dc.identifier.spage2802en_HK
dc.identifier.epage2809en_HK
dc.identifier.isiWOS:000283971400021-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridZhang, WB=37022069200en_HK
dc.identifier.scopusauthoridZheng, LW=11241247300en_HK
dc.identifier.scopusauthoridChua, D=7006773480en_HK
dc.identifier.scopusauthoridCheung, LK=7102302747en_HK

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