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Article: Effect of genistin on bone formation.

TitleEffect of genistin on bone formation.
Authors
Issue Date2010
Citation
Frontiers In Bioscience (Elite Edition), 2010, v. 2, p. 764-770 How to Cite?
AbstractThe amount of new bone produced by grafting genistin in collagen matrix was compared to the bone produced by collagen matrix alone. A total of 18 bone defects (5 mm by 10 mm) were created in the parietal bone of 9 New Zealand White rabbits. Six defects were grafted with genistin mixed with collagen matrix, while 6 were grafted with collagen matrix alone (positive control) and 6 were left empty (negative control). Animals were killed on day 14 and defects were prepared histologically. Quantitative analysis of new bone formation and bone cells was carried out on 100 sections (50 sections for each group) using image analysis. A total of 520 per cent more new bone was present in defects grafted with genistin in collagen matrix than in defects grafted with collagen matrix alone (p less than 0.0001), while no bone was formed in the negative control group. The amount of bone forming osteoblasts was also significantly greater in the genistin group than the positive control group. Therefore, genistin in collagen matrix can increase new bone formation locally in vivo.
Persistent Identifierhttp://hdl.handle.net/10722/154620
ISSN
2015 SCImago Journal Rankings: 0.900

 

DC FieldValueLanguage
dc.contributor.authorWong, RWen_US
dc.contributor.authorRabie, ABen_US
dc.date.accessioned2012-08-08T08:26:31Z-
dc.date.available2012-08-08T08:26:31Z-
dc.date.issued2010en_US
dc.identifier.citationFrontiers In Bioscience (Elite Edition), 2010, v. 2, p. 764-770en_US
dc.identifier.issn1945-0508en_US
dc.identifier.urihttp://hdl.handle.net/10722/154620-
dc.description.abstractThe amount of new bone produced by grafting genistin in collagen matrix was compared to the bone produced by collagen matrix alone. A total of 18 bone defects (5 mm by 10 mm) were created in the parietal bone of 9 New Zealand White rabbits. Six defects were grafted with genistin mixed with collagen matrix, while 6 were grafted with collagen matrix alone (positive control) and 6 were left empty (negative control). Animals were killed on day 14 and defects were prepared histologically. Quantitative analysis of new bone formation and bone cells was carried out on 100 sections (50 sections for each group) using image analysis. A total of 520 per cent more new bone was present in defects grafted with genistin in collagen matrix than in defects grafted with collagen matrix alone (p less than 0.0001), while no bone was formed in the negative control group. The amount of bone forming osteoblasts was also significantly greater in the genistin group than the positive control group. Therefore, genistin in collagen matrix can increase new bone formation locally in vivo.en_US
dc.languageengen_US
dc.relation.ispartofFrontiers in bioscience (Elite edition)en_US
dc.subject.meshAnimalsen_US
dc.subject.meshBone Transplantation - Methodsen_US
dc.subject.meshCollagenen_US
dc.subject.meshIsoflavones - Pharmacologyen_US
dc.subject.meshOsteogenesis - Drug Effects - Physiologyen_US
dc.subject.meshRabbitsen_US
dc.titleEffect of genistin on bone formation.en_US
dc.typeArticleen_US
dc.identifier.emailWong, RW:fyoung@hkucc.hku.hken_US
dc.identifier.emailRabie, AB:rabie@hku.hken_US
dc.identifier.authorityWong, RW=rp00038en_US
dc.identifier.authorityRabie, AB=rp00029en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid20036920-
dc.identifier.scopuseid_2-s2.0-77954517233en_US
dc.identifier.hkuros168791-
dc.identifier.volume2en_US
dc.identifier.spage764en_US
dc.identifier.epage770en_US
dc.identifier.scopusauthoridWong, RW=7402127170en_US
dc.identifier.scopusauthoridRabie, AB=7007172734en_US

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