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Article: Experimental superficial candidiasis on tissue models: Review article

TitleExperimental superficial candidiasis on tissue models: Review article
Authors
Issue Date2010
PublisherWiley-Blackwell Verlag GmbH. The Journal's web site is located at http://www.blackwellpublishing.com/journals/MYC
Citation
Mycoses, 2010, v. 53 n. 4, p. 285-295 How to Cite?
AbstractSummary Candida species are common pathogens causing superficial mycoses primarily affecting the mucosa and the skin in humans. Crucial steps during pathogenesis of superficial candidiasis comprise fungal adhesion, colonisation and subsequent penetration of the respective tissues. Exploring these pathological events and perhaps fungal and tissue responses towards drug treatment is imperative in the management of this infection. Unfortunately, pathological biopsies of superficial candidiasis do not exhibit the early changes in the host-pathogen interaction as the tissues are already invaded by the fungi. In vivo experimental assessments of pathological processes of superficial candidiasis are also limited because of the difficulties in providing reproducible and comparable conditions in the host environment. Conversely, in vitro models have helped studying fungal-host interactions under more defined and controlled conditions. Some common in vitro models used to simulate superficial candidiasis are chick chorioallantoic membrane, mucosal explants and single layer or multiple layer cell cultures. Interestingly, these experimental approaches share advantages as well as disadvantages when compared with in vivo conditions. Hence, this review intends to discuss about the experimental superficial candidiasis produced in various tissue models and their advantages as well as disadvantages with a particular reference to further improvement of validity and reliability of such experiments. © 2010 Blackwell Verlag GmbH.
Persistent Identifierhttp://hdl.handle.net/10722/154611
ISSN
2015 Impact Factor: 2.332
2015 SCImago Journal Rankings: 0.921
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorJayatilake, JAMSen_US
dc.contributor.authorSamaranayake, LPen_US
dc.date.accessioned2012-08-08T08:26:29Z-
dc.date.available2012-08-08T08:26:29Z-
dc.date.issued2010en_US
dc.identifier.citationMycoses, 2010, v. 53 n. 4, p. 285-295en_US
dc.identifier.issn0933-7407en_US
dc.identifier.urihttp://hdl.handle.net/10722/154611-
dc.description.abstractSummary Candida species are common pathogens causing superficial mycoses primarily affecting the mucosa and the skin in humans. Crucial steps during pathogenesis of superficial candidiasis comprise fungal adhesion, colonisation and subsequent penetration of the respective tissues. Exploring these pathological events and perhaps fungal and tissue responses towards drug treatment is imperative in the management of this infection. Unfortunately, pathological biopsies of superficial candidiasis do not exhibit the early changes in the host-pathogen interaction as the tissues are already invaded by the fungi. In vivo experimental assessments of pathological processes of superficial candidiasis are also limited because of the difficulties in providing reproducible and comparable conditions in the host environment. Conversely, in vitro models have helped studying fungal-host interactions under more defined and controlled conditions. Some common in vitro models used to simulate superficial candidiasis are chick chorioallantoic membrane, mucosal explants and single layer or multiple layer cell cultures. Interestingly, these experimental approaches share advantages as well as disadvantages when compared with in vivo conditions. Hence, this review intends to discuss about the experimental superficial candidiasis produced in various tissue models and their advantages as well as disadvantages with a particular reference to further improvement of validity and reliability of such experiments. © 2010 Blackwell Verlag GmbH.en_US
dc.languageengen_US
dc.publisherWiley-Blackwell Verlag GmbH. The Journal's web site is located at http://www.blackwellpublishing.com/journals/MYCen_US
dc.relation.ispartofMycosesen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCandida - Pathogenicityen_US
dc.subject.meshCandidiasis - Microbiologyen_US
dc.subject.meshHost-Pathogen Interactionsen_US
dc.subject.meshHumansen_US
dc.subject.meshOrgan Culture Techniquesen_US
dc.titleExperimental superficial candidiasis on tissue models: Review articleen_US
dc.typeArticleen_US
dc.identifier.emailSamaranayake, LP:lakshman@hku.hken_US
dc.identifier.authoritySamaranayake, LP=rp00023en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1439-0507.2010.01879.xen_US
dc.identifier.pmid20406388-
dc.identifier.scopuseid_2-s2.0-77953330987en_US
dc.identifier.hkuros181173-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77953330987&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume53en_US
dc.identifier.issue4en_US
dc.identifier.spage285en_US
dc.identifier.epage295en_US
dc.identifier.isiWOS:000278567800001-
dc.publisher.placeGermanyen_US
dc.identifier.scopusauthoridJayatilake, JAMS=8441671500en_US
dc.identifier.scopusauthoridSamaranayake, LP=7102761002en_US
dc.identifier.citeulike7406313-

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