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Conference Paper: Combination of radiological and biochemical methods to assess bone mineral density of mandible in fully edentulous patients after chemotherapy: A 5-year prospective study

TitleCombination of radiological and biochemical methods to assess bone mineral density of mandible in fully edentulous patients after chemotherapy: A 5-year prospective study
Authors
Issue Date2010
PublisherInforma Healthcare. The Journal's web site is located at http://www.expertopin.com/loi/eid
Citation
Expert Opinion On Investigational Drugs, 2010, v. 19 SUPPL. 1, p. S109-S115 How to Cite?
AbstractBackground: Osteoporosis is of concern in breast cancer patients who are undergoing chemotherapy. This study compared the bone mineral density (BMD) index of the mandible and hip hinge between patients who were undergoing chemotherapy or breast cancer, and fully edentulous Chinese patients without cancer over a period of 5 years. Method: 120 fully edentulous patients with an average age of 69 who had undergone mastectomy for grade two or three non-metastatic invasive breast ductal carcinoma. This was followed by administration of 5-fluorouracil, cyclophosphamide, and doxorubicin. The 118 fully edentulous cancer-free patients were included as a control group. The first assessment point was 6 months after chemotherapy treatment. The BMD and panoramic and side views of the mandible were measured by γ-ray and the BMD of left hip hinge was measured using dual energy X-ray absorptiometry. The serum and urine level of bone-specific alkaline phosphatase (BAP), carboxyterminal cross-linked telopeptide of type I collagen (ICTP), as well as liver and renal function tests were determined. These examinations were performed annually for 5 years. Result: The cancer patients demonstrated a statistically significant (p <0.05) increase in bone resorption of mandible and hip, and an increase in BAP and ICTP levels when compared with the control group. Although data were collected annually there was no statistical significance for the first 3 years. Conclusion: Breast cancer patients undergoing chemotherapy displayed significant resorption of mandibular bones compared with the healthy control, which might result in difficulties in fitting dentures, as it would cause pain and mucosal friction. Thus, concurrent therapy to decrease mandibular bone loss and special considerations in dentures are warranted for these patients. © 2010 Informa UK Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/154604
ISSN
2015 Impact Factor: 4.408
2015 SCImago Journal Rankings: 1.314
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLoo, WTYen_US
dc.contributor.authorJin, Len_US
dc.contributor.authorCheung, MNBen_US
dc.contributor.authorChow, LWCen_US
dc.contributor.authorWang, Men_US
dc.date.accessioned2012-08-08T08:26:27Z-
dc.date.available2012-08-08T08:26:27Z-
dc.date.issued2010en_US
dc.identifier.citationExpert Opinion On Investigational Drugs, 2010, v. 19 SUPPL. 1, p. S109-S115en_US
dc.identifier.issn1354-3784en_US
dc.identifier.urihttp://hdl.handle.net/10722/154604-
dc.description.abstractBackground: Osteoporosis is of concern in breast cancer patients who are undergoing chemotherapy. This study compared the bone mineral density (BMD) index of the mandible and hip hinge between patients who were undergoing chemotherapy or breast cancer, and fully edentulous Chinese patients without cancer over a period of 5 years. Method: 120 fully edentulous patients with an average age of 69 who had undergone mastectomy for grade two or three non-metastatic invasive breast ductal carcinoma. This was followed by administration of 5-fluorouracil, cyclophosphamide, and doxorubicin. The 118 fully edentulous cancer-free patients were included as a control group. The first assessment point was 6 months after chemotherapy treatment. The BMD and panoramic and side views of the mandible were measured by γ-ray and the BMD of left hip hinge was measured using dual energy X-ray absorptiometry. The serum and urine level of bone-specific alkaline phosphatase (BAP), carboxyterminal cross-linked telopeptide of type I collagen (ICTP), as well as liver and renal function tests were determined. These examinations were performed annually for 5 years. Result: The cancer patients demonstrated a statistically significant (p <0.05) increase in bone resorption of mandible and hip, and an increase in BAP and ICTP levels when compared with the control group. Although data were collected annually there was no statistical significance for the first 3 years. Conclusion: Breast cancer patients undergoing chemotherapy displayed significant resorption of mandibular bones compared with the healthy control, which might result in difficulties in fitting dentures, as it would cause pain and mucosal friction. Thus, concurrent therapy to decrease mandibular bone loss and special considerations in dentures are warranted for these patients. © 2010 Informa UK Ltd.en_US
dc.languageengen_US
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.expertopin.com/loi/eiden_US
dc.relation.ispartofExpert Opinion on Investigational Drugsen_US
dc.subject.meshAbsorptiometry, Photonen_US
dc.subject.meshAgeden_US
dc.subject.meshAntineoplastic Combined Chemotherapy Protocols - Adverse Effects - Therapeutic Useen_US
dc.subject.meshBone Density - Drug Effectsen_US
dc.subject.meshBone Resorption - Chemically Induceden_US
dc.subject.meshBreast Neoplasms - Drug Therapy - Surgeryen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshChinaen_US
dc.subject.meshCombined Modality Therapyen_US
dc.subject.meshCyclophosphamide - Administration & Dosageen_US
dc.subject.meshDenture, Completeen_US
dc.subject.meshDoxorubicin - Administration & Dosageen_US
dc.subject.meshFemaleen_US
dc.subject.meshFluorouracil - Administration & Dosageen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHip - Pathologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMandible - Pathologyen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMouth, Edentulous - Complicationsen_US
dc.subject.meshOsteoporosis - Chemically Induced - Diagnosisen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshProsthesis Fitting - Methodsen_US
dc.subject.meshTime Factorsen_US
dc.titleCombination of radiological and biochemical methods to assess bone mineral density of mandible in fully edentulous patients after chemotherapy: A 5-year prospective studyen_US
dc.typeConference_Paperen_US
dc.identifier.emailJin, L:ljjin@hkucc.hku.hken_US
dc.identifier.authorityJin, L=rp00028en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1517/13543781003727065en_US
dc.identifier.pmid20374022-
dc.identifier.scopuseid_2-s2.0-77950654276en_US
dc.identifier.hkuros180203-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77950654276&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume19en_US
dc.identifier.issueSUPPL. 1en_US
dc.identifier.spageS109en_US
dc.identifier.epageS115en_US
dc.identifier.isiWOS:000276415800014-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLoo, WTY=7003567474en_US
dc.identifier.scopusauthoridJin, L=7403328850en_US
dc.identifier.scopusauthoridCheung, MNB=7201897548en_US
dc.identifier.scopusauthoridChow, LWC=34975216600en_US
dc.identifier.scopusauthoridWang, M=36080215600en_US

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