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Conference Paper: Rhodiola algida improves chemotherapy-induced oral mucositis in breast cancer patients

TitleRhodiola algida improves chemotherapy-induced oral mucositis in breast cancer patients
Authors
Issue Date2010
PublisherInforma Healthcare. The Journal's web site is located at http://www.expertopin.com/loi/eid
Citation
Expert Opinion On Investigational Drugs, 2010, v. 19 SUPPL. 1, p. S91-S100 How to Cite?
AbstractObjective: Oral ulcerative mucositis, a common adverse effect due to mainstream cytotoxic drugs, limits the nutritional intake of cancer patients. Rhodiola algida is widely used in traditional Chinese medicine to stimulate the immune system. The aim of this study is to investigate the effect of this herbal extract on healthy human lymphocytes in vitro, the homeostasis of cancer patients and the healing time of oral ulcers. Method: The constituents of Rhodiola algida were analyzed by RP-HPLC. Lymphocytes isolated from 462 healthy subjects were treated with 100 ug/ml Rhodiola algida for 48 h. The activity of the cells was measured by cell proliferation reagent and ATP assay. The level of various cytokines and mRNA content of lymphocytes were determined. Rhodiola algida demonstrated no toxicity in animals, which had been orally fed with 1 mg/ml Rhodiola algida for 30 days. 130 breast cancer patients from Huaxi Hospital of Sichuan University were recruited between 2006 and 2007. They received four cycles of 5-fluorouracil, epirubicin and cyclophosphamide after modified total mastectomy. These patients were randomly assigned to test and control groups. Rhodiola algida mixture was consumed by the test group for 14 consecutive days after each cycle of chemotherapy. All patients were given 0.2% chlorohexidine mouth wash to be used every day. Complete blood counts, liver and renal function tests together with the number and size of oral ulcerations were analyzed after each cycle. Weight loss, complaints of nausea or vomiting and degree of pain were noted. Results: The optimal concentration of Rhodiola algida favored the proliferation of lymphocytes. The levels of IL-2, IL-4, granulocyte-macrophage colony-stimulating factor and the mRNA content of these cytokines were also enhanced. White blood cell (WBC) levels returned to normal range in both groups 1 week after every cycle of chemotherapy. WBC count increased faster in patients using Rhodiola algida; they presented with smaller and fewer oral ulcers. There were no liver or renal complications observed in any patients. Conclusion: Rhodiola algida increases immunity of patients who are receiving chemotherapy post mastectomy and decreases the quantity of oral ulcers. Thus Rhodiola algida has the potential to be used concurrently with chemotherapy to alleviate the occurrence of oral ulcers. © 2010 Informa UK Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/154603
ISSN
2015 Impact Factor: 4.408
2015 SCImago Journal Rankings: 1.314
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLoo, WTYen_US
dc.contributor.authorJin, Len_US
dc.contributor.authorChow, LWCen_US
dc.contributor.authorCheung, MNBen_US
dc.contributor.authorWang, Men_US
dc.date.accessioned2012-08-08T08:26:27Z-
dc.date.available2012-08-08T08:26:27Z-
dc.date.issued2010en_US
dc.identifier.citationExpert Opinion On Investigational Drugs, 2010, v. 19 SUPPL. 1, p. S91-S100en_US
dc.identifier.issn1354-3784en_US
dc.identifier.urihttp://hdl.handle.net/10722/154603-
dc.description.abstractObjective: Oral ulcerative mucositis, a common adverse effect due to mainstream cytotoxic drugs, limits the nutritional intake of cancer patients. Rhodiola algida is widely used in traditional Chinese medicine to stimulate the immune system. The aim of this study is to investigate the effect of this herbal extract on healthy human lymphocytes in vitro, the homeostasis of cancer patients and the healing time of oral ulcers. Method: The constituents of Rhodiola algida were analyzed by RP-HPLC. Lymphocytes isolated from 462 healthy subjects were treated with 100 ug/ml Rhodiola algida for 48 h. The activity of the cells was measured by cell proliferation reagent and ATP assay. The level of various cytokines and mRNA content of lymphocytes were determined. Rhodiola algida demonstrated no toxicity in animals, which had been orally fed with 1 mg/ml Rhodiola algida for 30 days. 130 breast cancer patients from Huaxi Hospital of Sichuan University were recruited between 2006 and 2007. They received four cycles of 5-fluorouracil, epirubicin and cyclophosphamide after modified total mastectomy. These patients were randomly assigned to test and control groups. Rhodiola algida mixture was consumed by the test group for 14 consecutive days after each cycle of chemotherapy. All patients were given 0.2% chlorohexidine mouth wash to be used every day. Complete blood counts, liver and renal function tests together with the number and size of oral ulcerations were analyzed after each cycle. Weight loss, complaints of nausea or vomiting and degree of pain were noted. Results: The optimal concentration of Rhodiola algida favored the proliferation of lymphocytes. The levels of IL-2, IL-4, granulocyte-macrophage colony-stimulating factor and the mRNA content of these cytokines were also enhanced. White blood cell (WBC) levels returned to normal range in both groups 1 week after every cycle of chemotherapy. WBC count increased faster in patients using Rhodiola algida; they presented with smaller and fewer oral ulcers. There were no liver or renal complications observed in any patients. Conclusion: Rhodiola algida increases immunity of patients who are receiving chemotherapy post mastectomy and decreases the quantity of oral ulcers. Thus Rhodiola algida has the potential to be used concurrently with chemotherapy to alleviate the occurrence of oral ulcers. © 2010 Informa UK Ltd.en_US
dc.languageengen_US
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.expertopin.com/loi/eiden_US
dc.relation.ispartofExpert Opinion on Investigational Drugsen_US
dc.subject.meshAdulten_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntineoplastic Agents - Adverse Effects - Therapeutic Useen_US
dc.subject.meshBreast Neoplasms - Drug Therapy - Surgeryen_US
dc.subject.meshCell Proliferation - Drug Effectsen_US
dc.subject.meshChromatography, High Pressure Liquiden_US
dc.subject.meshCytokines - Metabolismen_US
dc.subject.meshDrugs, Chinese Herbal - Adverse Effects - Pharmacologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLymphocytes - Drug Effects - Metabolismen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPilot Projectsen_US
dc.subject.meshPlant Extracts - Adverse Effects - Pharmacologyen_US
dc.subject.meshRna, Messenger - Metabolismen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshRhodiola - Chemistryen_US
dc.subject.meshStomatitis - Chemically Induced - Drug Therapyen_US
dc.subject.meshYoung Adulten_US
dc.titleRhodiola algida improves chemotherapy-induced oral mucositis in breast cancer patientsen_US
dc.typeConference_Paperen_US
dc.identifier.emailJin, L:ljjin@hkucc.hku.hken_US
dc.identifier.authorityJin, L=rp00028en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1517/13543781003727057en_US
dc.identifier.pmid20374035-
dc.identifier.scopuseid_2-s2.0-77950631233en_US
dc.identifier.hkuros180194-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77950631233&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume19en_US
dc.identifier.issueSUPPL. 1en_US
dc.identifier.spageS91en_US
dc.identifier.epageS100en_US
dc.identifier.isiWOS:000276415800012-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLoo, WTY=7003567474en_US
dc.identifier.scopusauthoridJin, L=7403328850en_US
dc.identifier.scopusauthoridChow, LWC=7202532995en_US
dc.identifier.scopusauthoridCheung, MNB=7201897548en_US
dc.identifier.scopusauthoridWang, M=36080215600en_US

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