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Article: Effect of amine fluoride-stannous fluoride preparations on oral yeasts in the elderly: A randomised placebo-controlled trial

TitleEffect of amine fluoride-stannous fluoride preparations on oral yeasts in the elderly: A randomised placebo-controlled trial
Authors
Issue Date2009
PublisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0734-0664&site=1
Citation
Gerodontology, 2009, v. 26 n. 3, p. 202-209 How to Cite?
AbstractObjectives: Oral yeast infections are an emerging problem among medically compromised and frail elderly. Antifungal drug resistance is also increasing because of an increase in non-albicans Candida strains in these populations. We therefore set out to study, in the randomised-controlled trial setting if the use of a topical amine fluoride-stannous luoride combination (AmF-SnF 2) could control oral Candida growth in the elderly. The hypothesis was based on earlier findings showing that in vitro this combination had antifungal efficacy. Methods: A total of 194 nursing home residents were randomised to receive either the test mouth rinse and toothpaste or a placebo twice daily for 8 months. Of these, 136 completed the trial. Saliva samples were taken using the oral rinse method, cultivated and the strain level identified with routine microbial methods. Compliance and use of preparations was assessed by a nurse. Results: Significantly at the end of the trial, less mucosal lesions were observed in the test group in comparison to controls. Total bacterial count decreased in both the groups during the trial. Candida albicans was the most prevalent strain detected both at baseline and 8 months later. Only a few subjects carried non-albicans strains. The AmF-SnF2 did not significantly affect mean oral Candida counts, but median Candida counts were reduced in the AmF-SnF2 group while an increase was seen in the placebo group. However, the differences observed were not statistically significant. Compliance among the regular elderly users slightly increased during the trial for both the groups. Conclusion: The number of subjects with high Candida counts decreased in the AmF-SnF2 group. Hence, the fluoride combination might be useful as a support therapy for oral candidiasis. Prevalence of non-albicans Candida strains was low in this population. © 2009 The Gerodontology Society and John Wiley & Sons A/S.
Persistent Identifierhttp://hdl.handle.net/10722/154581
ISSN
2015 Impact Factor: 1.396
2015 SCImago Journal Rankings: 0.643
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMeurman, JHen_US
dc.contributor.authorPärnänen, Pen_US
dc.contributor.authorKari, Ken_US
dc.contributor.authorSamaranayake, Len_US
dc.date.accessioned2012-08-08T08:26:18Z-
dc.date.available2012-08-08T08:26:18Z-
dc.date.issued2009en_US
dc.identifier.citationGerodontology, 2009, v. 26 n. 3, p. 202-209en_US
dc.identifier.issn0734-0664en_US
dc.identifier.urihttp://hdl.handle.net/10722/154581-
dc.description.abstractObjectives: Oral yeast infections are an emerging problem among medically compromised and frail elderly. Antifungal drug resistance is also increasing because of an increase in non-albicans Candida strains in these populations. We therefore set out to study, in the randomised-controlled trial setting if the use of a topical amine fluoride-stannous luoride combination (AmF-SnF 2) could control oral Candida growth in the elderly. The hypothesis was based on earlier findings showing that in vitro this combination had antifungal efficacy. Methods: A total of 194 nursing home residents were randomised to receive either the test mouth rinse and toothpaste or a placebo twice daily for 8 months. Of these, 136 completed the trial. Saliva samples were taken using the oral rinse method, cultivated and the strain level identified with routine microbial methods. Compliance and use of preparations was assessed by a nurse. Results: Significantly at the end of the trial, less mucosal lesions were observed in the test group in comparison to controls. Total bacterial count decreased in both the groups during the trial. Candida albicans was the most prevalent strain detected both at baseline and 8 months later. Only a few subjects carried non-albicans strains. The AmF-SnF2 did not significantly affect mean oral Candida counts, but median Candida counts were reduced in the AmF-SnF2 group while an increase was seen in the placebo group. However, the differences observed were not statistically significant. Compliance among the regular elderly users slightly increased during the trial for both the groups. Conclusion: The number of subjects with high Candida counts decreased in the AmF-SnF2 group. Hence, the fluoride combination might be useful as a support therapy for oral candidiasis. Prevalence of non-albicans Candida strains was low in this population. © 2009 The Gerodontology Society and John Wiley & Sons A/S.en_US
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0734-0664&site=1en_US
dc.relation.ispartofGerodontologyen_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshAmines - Therapeutic Useen_US
dc.subject.meshAntifungal Agents - Therapeutic Useen_US
dc.subject.meshCandida - Classification - Drug Effectsen_US
dc.subject.meshCandidiasis, Oral - Prevention & Controlen_US
dc.subject.meshDental Care For Aged - Methodsen_US
dc.subject.meshDrug Combinationsen_US
dc.subject.meshFemaleen_US
dc.subject.meshFluorides, Topical - Therapeutic Useen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMouth - Drug Effects - Microbiologyen_US
dc.subject.meshMouthwashes - Therapeutic Useen_US
dc.subject.meshNursing Homesen_US
dc.subject.meshOral Hygiene - Methodsen_US
dc.subject.meshTin Fluorides - Therapeutic Useen_US
dc.subject.meshToothpastes - Therapeutic Useen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleEffect of amine fluoride-stannous fluoride preparations on oral yeasts in the elderly: A randomised placebo-controlled trialen_US
dc.typeArticleen_US
dc.identifier.emailSamaranayake, L:lakshman@hku.hken_US
dc.identifier.authoritySamaranayake, L=rp00023en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1741-2358.2008.00246.xen_US
dc.identifier.pmid19702819en_US
dc.identifier.scopuseid_2-s2.0-68949083486en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-68949083486&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume26en_US
dc.identifier.issue3en_US
dc.identifier.spage202en_US
dc.identifier.epage209en_US
dc.identifier.isiWOS:000268926600007-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridMeurman, JH=7006469347en_US
dc.identifier.scopusauthoridPärnänen, P=24344880300en_US
dc.identifier.scopusauthoridKari, K=6603526983en_US
dc.identifier.scopusauthoridSamaranayake, L=7102761002en_US
dc.identifier.citeulike5441591-

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