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Article: Chlorhexidine release and water sorption characteristics of chlorhexidine-incorporated hydrophobic/hydrophilic resins

TitleChlorhexidine release and water sorption characteristics of chlorhexidine-incorporated hydrophobic/hydrophilic resins
Authors
KeywordsChlorhexidine
Drug release
Hoy's solubility parameters
Hydrophilic resin
Hydrophobic resin
Solubility
Water sorption
Issue Date2008
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/dental
Citation
Dental Materials, 2008, v. 24 n. 10, p. 1391-1399 How to Cite?
AbstractObjectives: The aim of this study was to evaluate chlorhexidine release from unfilled non-solvated methacrylate-based resins of increasing hydrophilicity and to examine relationships among Hoy's solubility parameters, water sorption, solubility and the rate of chlorhexidine release. Methods: Resin discs were prepared from light-cured, experimental resin blends (R1, R2, R3, R4 and R5) containing 0.0, 0.2, 1.0 and 2.0 wt.% chlorhexidine diacetate (CDA). Discs were immersed in distilled water at 37 °C, and mass changes were recorded at different periods. Spectral measurements were made to follow change in optical densities of storage solution to examine chlorhexidine release kinetics. After a 28-day period, water sorption, solubility, and the cumulative chlorhexidine release were obtained. Additionally, antibacterial study was performed by observing the presence of inhibition zone against Streptococcus mutans. Results: The most hydrophilic resin (R5) exhibited the highest chlorhexidine release rate. The most hydrophobic resin (R1) exhibited the lowest rate. However, no inhibition zone was produced by any specimens stored in water for 2 weeks. The addition of CDA increased solubility significantly but had no effect on water sorption. Significant positive correlations were seen between water sorption and the cumulative chlorhexidine release. Significance: Chlorhexidine release from resins may be related to water-induced swelling, which in turn is enhanced by the hydrophilicity of cured polymer matrix. © 2008 Academy of Dental Materials.
Persistent Identifierhttp://hdl.handle.net/10722/154538
ISSN
2015 Impact Factor: 3.931
2015 SCImago Journal Rankings: 1.339
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
University of Hong Kong10207401/14207/08004/323/01
10207821.14207.8004.324.01
NIDCRDE 014911
DE 015306
Funding Information:

The resin blends used in this study were generous gifts from Bisco, Inc. This study was supported in part, by grant 10207401/14207/08004/323/01 and 10207821.14207. 8004.324.01, Faculty of Dentistry, The University of Hong Kong, and by grants DE 014911 and DE 015306 from NIDCR to DHP (PI). The authors are grateful to Zinnia Pang and Michelle Barnes for their secretarial assistance.

References

 

DC FieldValueLanguage
dc.contributor.authorHiraishi, Nen_HK
dc.contributor.authorYiu, CKYen_HK
dc.contributor.authorKing, NMen_HK
dc.contributor.authorTay, FRCMen_HK
dc.contributor.authorPashley, DHen_HK
dc.date.accessioned2012-08-08T08:26:03Z-
dc.date.available2012-08-08T08:26:03Z-
dc.date.issued2008en_HK
dc.identifier.citationDental Materials, 2008, v. 24 n. 10, p. 1391-1399en_HK
dc.identifier.issn0109-5641en_HK
dc.identifier.urihttp://hdl.handle.net/10722/154538-
dc.description.abstractObjectives: The aim of this study was to evaluate chlorhexidine release from unfilled non-solvated methacrylate-based resins of increasing hydrophilicity and to examine relationships among Hoy's solubility parameters, water sorption, solubility and the rate of chlorhexidine release. Methods: Resin discs were prepared from light-cured, experimental resin blends (R1, R2, R3, R4 and R5) containing 0.0, 0.2, 1.0 and 2.0 wt.% chlorhexidine diacetate (CDA). Discs were immersed in distilled water at 37 °C, and mass changes were recorded at different periods. Spectral measurements were made to follow change in optical densities of storage solution to examine chlorhexidine release kinetics. After a 28-day period, water sorption, solubility, and the cumulative chlorhexidine release were obtained. Additionally, antibacterial study was performed by observing the presence of inhibition zone against Streptococcus mutans. Results: The most hydrophilic resin (R5) exhibited the highest chlorhexidine release rate. The most hydrophobic resin (R1) exhibited the lowest rate. However, no inhibition zone was produced by any specimens stored in water for 2 weeks. The addition of CDA increased solubility significantly but had no effect on water sorption. Significant positive correlations were seen between water sorption and the cumulative chlorhexidine release. Significance: Chlorhexidine release from resins may be related to water-induced swelling, which in turn is enhanced by the hydrophilicity of cured polymer matrix. © 2008 Academy of Dental Materials.en_HK
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/dentalen_HK
dc.relation.ispartofDental Materialsen_HK
dc.rightsDental Materials. Copyright © Elsevier Inc.-
dc.subjectChlorhexidineen_HK
dc.subjectDrug releaseen_HK
dc.subjectHoy's solubility parametersen_HK
dc.subjectHydrophilic resinen_HK
dc.subjectHydrophobic resinen_HK
dc.subjectSolubilityen_HK
dc.subjectWater sorptionen_HK
dc.subject.mesh4-Aminobenzoic Acid - Analogs & Derivatives - Chemistryen_US
dc.subject.meshAbsorptionen_US
dc.subject.meshAcrylic Resins - Chemistryen_US
dc.subject.meshAdsorptionen_US
dc.subject.meshAnti-Infective Agents, Local - Chemistry - Pharmacologyen_US
dc.subject.meshBisphenol A-Glycidyl Methacrylate - Chemistryen_US
dc.subject.meshChlorhexidine - Chemistry - Pharmacologyen_US
dc.subject.meshCyclohexenes - Chemistryen_US
dc.subject.meshDental Materials - Chemistryen_US
dc.subject.meshDiffusionen_US
dc.subject.meshHumansen_US
dc.subject.meshHydrophobic And Hydrophilic Interactionsen_US
dc.subject.meshMaterials Testingen_US
dc.subject.meshMethacrylates - Chemistryen_US
dc.subject.meshPolyethylene Glycols - Chemistryen_US
dc.subject.meshPolyhydroxyethyl Methacrylate - Analogs & Derivatives - Chemistryen_US
dc.subject.meshPolymethacrylic Acids - Chemistryen_US
dc.subject.meshSolubilityen_US
dc.subject.meshSpectrum Analysisen_US
dc.subject.meshStreptococcus Mutans - Drug Effectsen_US
dc.subject.meshTemperatureen_US
dc.subject.meshTime Factorsen_US
dc.subject.meshWater - Chemistryen_US
dc.subject.meshWettabilityen_US
dc.titleChlorhexidine release and water sorption characteristics of chlorhexidine-incorporated hydrophobic/hydrophilic resinsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0109-5641&volume=24&spage=1391&epage=9&date=2008&atitle=Chlorhexidine+release+and+water+sorption+characterisitcs+of+chlorhexidine-incorporated+hydrophobic/hydrophilic+resins.-
dc.identifier.emailHiraishi, N: hiraishinoriko@yahoo.comen_HK
dc.identifier.emailYiu, CKY: ckyyiu@hkucc.hku.hken_HK
dc.identifier.emailKing, NM: hhdbknm@hkucc.hku.hk-
dc.identifier.emailTay, FRCM: franktay@HKUCC.hku.hk-
dc.identifier.authorityYiu, CKY=rp00018en_HK
dc.identifier.authorityKing, NM=rp00006en_HK
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1016/j.dental.2008.03.011en_HK
dc.identifier.pmid18439668-
dc.identifier.pmcidPMC3886642-
dc.identifier.scopuseid_2-s2.0-48749102387en_HK
dc.identifier.hkuros147098-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-48749102387&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume24en_HK
dc.identifier.issue10en_HK
dc.identifier.spage1391en_HK
dc.identifier.epage1399en_HK
dc.identifier.isiWOS:000259359800013-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHiraishi, N=8925934400en_HK
dc.identifier.scopusauthoridYiu, CKY=7007115156en_HK
dc.identifier.scopusauthoridKing, NM=7201762850en_HK
dc.identifier.scopusauthoridTay, FR=7102091962en_HK
dc.identifier.scopusauthoridPashley, DH=35448600800en_HK

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