Article: The development of a novel automated taste stimulus delivery system for fMRI studies on the human cortical segregation of taste

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TitleThe development of a novel automated taste stimulus delivery system for fMRI studies on the human cortical segregation of taste
AuthorsKami, YN1
Goto, TK1
Tokumori, K1
Yoshiura, T1
Kobayashi, K2
Nakamura, Y2
Honda, H1
Ninomiya, Y1
Yoshiura, K1
Issue Date2008
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jneumeth
CitationJournal Of Neuroscience Methods, 2008, v. 172 n. 1, p. 48-53 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.jneumeth.2008.04.009
AbstractfMRI indicated that the primary taste cortex is activated not only by taste but also by non-taste information from oral stimuli. Head movements caused by swallowing are very critical problem in fMRI and inherent difficulties to modulate taste stimuli in the mouth exist to elucidate functional segregation of human brain. We developed a novel automated taste stimulus delivery system for fMRI studies to segregate the pure taste area in the primary taste cortex in humans. As a novel intra-oral device, an elliptic cylinder was attached to an individual mouthpiece and then subject placed the tongue tip in it. Using a computer-controlled extra-oral device, the solutions ran through the intra-oral device in constant conditions. Three adult volunteers participated in the experimental session, alternately consisting of 30 pairs of taste stimuli (0.5 mol/l sucrose solution) and control (water) blocks. The typical findings of the three subjects revealed activation only in the primary taste cortex (P < 0.001), and none in the secondary taste cortex. This is the first system that delivers the taste stimuli automatically to a standardized area on the subject's tongue under constant conditions, thus allowing us to successfully segregate the pure taste area in the primary taste cortex in humans. © 2008 Elsevier B.V. All rights reserved.
ISSN0165-0270
2011 Impact Factor: 1.98
2011 SCImago Journal Rankings: 0.227
DOIhttp://dx.doi.org/10.1016/j.jneumeth.2008.04.009
ISI Accession Number IDWOS:000257485800009
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorKami, YN
dc.contributor.authorGoto, TK
dc.contributor.authorTokumori, K
dc.contributor.authorYoshiura, T
dc.contributor.authorKobayashi, K
dc.contributor.authorNakamura, Y
dc.contributor.authorHonda, H
dc.contributor.authorNinomiya, Y
dc.contributor.authorYoshiura, K
dc.date.accessioned2012-08-08T08:25:57Z
dc.date.available2012-08-08T08:25:57Z
dc.date.issued2008
dc.description.abstractfMRI indicated that the primary taste cortex is activated not only by taste but also by non-taste information from oral stimuli. Head movements caused by swallowing are very critical problem in fMRI and inherent difficulties to modulate taste stimuli in the mouth exist to elucidate functional segregation of human brain. We developed a novel automated taste stimulus delivery system for fMRI studies to segregate the pure taste area in the primary taste cortex in humans. As a novel intra-oral device, an elliptic cylinder was attached to an individual mouthpiece and then subject placed the tongue tip in it. Using a computer-controlled extra-oral device, the solutions ran through the intra-oral device in constant conditions. Three adult volunteers participated in the experimental session, alternately consisting of 30 pairs of taste stimuli (0.5 mol/l sucrose solution) and control (water) blocks. The typical findings of the three subjects revealed activation only in the primary taste cortex (P < 0.001), and none in the secondary taste cortex. This is the first system that delivers the taste stimuli automatically to a standardized area on the subject's tongue under constant conditions, thus allowing us to successfully segregate the pure taste area in the primary taste cortex in humans. © 2008 Elsevier B.V. All rights reserved.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationJournal Of Neuroscience Methods, 2008, v. 172 n. 1, p. 48-53 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.jneumeth.2008.04.009
dc.identifier.doihttp://dx.doi.org/10.1016/j.jneumeth.2008.04.009
dc.identifier.epage53
dc.identifier.isiWOS:000257485800009
dc.identifier.issn0165-0270
2011 Impact Factor: 1.98
2011 SCImago Journal Rankings: 0.227
dc.identifier.issue1
dc.identifier.pmid18511125
dc.identifier.scopuseid_2-s2.0-44449151475
dc.identifier.spage48
dc.identifier.urihttp://hdl.handle.net/10722/154521
dc.identifier.volume172
dc.languageeng
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jneumeth
dc.publisher.placeNetherlands
dc.relation.ispartofJournal of Neuroscience Methods
dc.relation.referencesReferences in Scopus
dc.subject.meshAdministration, Oral
dc.subject.meshAdult
dc.subject.meshBrain Mapping
dc.subject.meshCerebral Cortex - Blood Supply - Physiology
dc.subject.meshDrug Delivery Systems - Instrumentation - Methods
dc.subject.meshFemale
dc.subject.meshFlavoring Agents - Administration & Dosage
dc.subject.meshHumans
dc.subject.meshImage Processing, Computer-Assisted - Methods
dc.subject.meshMagnetic Resonance Imaging
dc.subject.meshOxygen - Blood
dc.subject.meshSucrose - Administration & Dosage
dc.subject.meshTaste - Drug Effects - Physiology
dc.titleThe development of a novel automated taste stimulus delivery system for fMRI studies on the human cortical segregation of taste
dc.typeArticle
Author Affiliations
  1. Kyushu University
  2. Kyushu University Hospital