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Article: The development of a novel automated taste stimulus delivery system for fMRI studies on the human cortical segregation of taste
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TitleThe development of a novel automated taste stimulus delivery system for fMRI studies on the human cortical segregation of taste
 
AuthorsKami, YN1
Goto, TK1
Tokumori, K1
Yoshiura, T1
Kobayashi, K2
Nakamura, Y2
Honda, H1
Ninomiya, Y1
Yoshiura, K1
 
Issue Date2008
 
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jneumeth
 
CitationJournal Of Neuroscience Methods, 2008, v. 172 n. 1, p. 48-53 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.jneumeth.2008.04.009
 
AbstractfMRI indicated that the primary taste cortex is activated not only by taste but also by non-taste information from oral stimuli. Head movements caused by swallowing are very critical problem in fMRI and inherent difficulties to modulate taste stimuli in the mouth exist to elucidate functional segregation of human brain. We developed a novel automated taste stimulus delivery system for fMRI studies to segregate the pure taste area in the primary taste cortex in humans. As a novel intra-oral device, an elliptic cylinder was attached to an individual mouthpiece and then subject placed the tongue tip in it. Using a computer-controlled extra-oral device, the solutions ran through the intra-oral device in constant conditions. Three adult volunteers participated in the experimental session, alternately consisting of 30 pairs of taste stimuli (0.5 mol/l sucrose solution) and control (water) blocks. The typical findings of the three subjects revealed activation only in the primary taste cortex (P < 0.001), and none in the secondary taste cortex. This is the first system that delivers the taste stimuli automatically to a standardized area on the subject's tongue under constant conditions, thus allowing us to successfully segregate the pure taste area in the primary taste cortex in humans. © 2008 Elsevier B.V. All rights reserved.
 
ISSN0165-0270
2013 Impact Factor: 1.959
2013 SCImago Journal Rankings: 1.208
 
DOIhttp://dx.doi.org/10.1016/j.jneumeth.2008.04.009
 
ISI Accession Number IDWOS:000257485800009
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorKami, YN
 
dc.contributor.authorGoto, TK
 
dc.contributor.authorTokumori, K
 
dc.contributor.authorYoshiura, T
 
dc.contributor.authorKobayashi, K
 
dc.contributor.authorNakamura, Y
 
dc.contributor.authorHonda, H
 
dc.contributor.authorNinomiya, Y
 
dc.contributor.authorYoshiura, K
 
dc.date.accessioned2012-08-08T08:25:57Z
 
dc.date.available2012-08-08T08:25:57Z
 
dc.date.issued2008
 
dc.description.abstractfMRI indicated that the primary taste cortex is activated not only by taste but also by non-taste information from oral stimuli. Head movements caused by swallowing are very critical problem in fMRI and inherent difficulties to modulate taste stimuli in the mouth exist to elucidate functional segregation of human brain. We developed a novel automated taste stimulus delivery system for fMRI studies to segregate the pure taste area in the primary taste cortex in humans. As a novel intra-oral device, an elliptic cylinder was attached to an individual mouthpiece and then subject placed the tongue tip in it. Using a computer-controlled extra-oral device, the solutions ran through the intra-oral device in constant conditions. Three adult volunteers participated in the experimental session, alternately consisting of 30 pairs of taste stimuli (0.5 mol/l sucrose solution) and control (water) blocks. The typical findings of the three subjects revealed activation only in the primary taste cortex (P < 0.001), and none in the secondary taste cortex. This is the first system that delivers the taste stimuli automatically to a standardized area on the subject's tongue under constant conditions, thus allowing us to successfully segregate the pure taste area in the primary taste cortex in humans. © 2008 Elsevier B.V. All rights reserved.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationJournal Of Neuroscience Methods, 2008, v. 172 n. 1, p. 48-53 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.jneumeth.2008.04.009
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.jneumeth.2008.04.009
 
dc.identifier.eissn1872-678X
 
dc.identifier.epage53
 
dc.identifier.isiWOS:000257485800009
 
dc.identifier.issn0165-0270
2013 Impact Factor: 1.959
2013 SCImago Journal Rankings: 1.208
 
dc.identifier.issue1
 
dc.identifier.pmid18511125
 
dc.identifier.scopuseid_2-s2.0-44449151475
 
dc.identifier.spage48
 
dc.identifier.urihttp://hdl.handle.net/10722/154521
 
dc.identifier.volume172
 
dc.languageeng
 
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jneumeth
 
dc.publisher.placeNetherlands
 
dc.relation.ispartofJournal of Neuroscience Methods
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAdministration, Oral
 
dc.subject.meshAdult
 
dc.subject.meshBrain Mapping
 
dc.subject.meshCerebral Cortex - Blood Supply - Physiology
 
dc.subject.meshDrug Delivery Systems - Instrumentation - Methods
 
dc.subject.meshFemale
 
dc.subject.meshFlavoring Agents - Administration & Dosage
 
dc.subject.meshHumans
 
dc.subject.meshImage Processing, Computer-Assisted - Methods
 
dc.subject.meshMagnetic Resonance Imaging
 
dc.subject.meshOxygen - Blood
 
dc.subject.meshSucrose - Administration & Dosage
 
dc.subject.meshTaste - Drug Effects - Physiology
 
dc.titleThe development of a novel automated taste stimulus delivery system for fMRI studies on the human cortical segregation of taste
 
dc.typeArticle
 
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<description.abstract>fMRI indicated that the primary taste cortex is activated not only by taste but also by non-taste information from oral stimuli. Head movements caused by swallowing are very critical problem in fMRI and inherent difficulties to modulate taste stimuli in the mouth exist to elucidate functional segregation of human brain. We developed a novel automated taste stimulus delivery system for fMRI studies to segregate the pure taste area in the primary taste cortex in humans. As a novel intra-oral device, an elliptic cylinder was attached to an individual mouthpiece and then subject placed the tongue tip in it. Using a computer-controlled extra-oral device, the solutions ran through the intra-oral device in constant conditions. Three adult volunteers participated in the experimental session, alternately consisting of 30 pairs of taste stimuli (0.5 mol/l sucrose solution) and control (water) blocks. The typical findings of the three subjects revealed activation only in the primary taste cortex (P &lt; 0.001), and none in the secondary taste cortex. This is the first system that delivers the taste stimuli automatically to a standardized area on the subject&apos;s tongue under constant conditions, thus allowing us to successfully segregate the pure taste area in the primary taste cortex in humans. &#169; 2008 Elsevier B.V. All rights reserved.</description.abstract>
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Author Affiliations
  1. Kyushu University
  2. Kyushu University Hospital