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Article: Clinical outcomes following treatment of human intrabony defects with GTR/bone replacement material or access flap alone: A multicenter randomized controlled clinical trial

TitleClinical outcomes following treatment of human intrabony defects with GTR/bone replacement material or access flap alone: A multicenter randomized controlled clinical trial
Authors
Issue Date2004
PublisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CPE
Citation
Journal Of Clinical Periodontology, 2004, v. 31 n. 9, p. 770-776 How to Cite?
AbstractAim: This prospective multicenter randomized controlled clinical trial was designed to compare the clinical outcomes of papilla preservation flap surgery with or without the application of a guided tissue regeneration (GTR)/bone replacement material. Materials and Methods: One hundred and twenty-four patients with advanced chronic periodontitis were recruited in 10 centers in seven countries. All patients had at least one intrabony defect of ≥ 3 mm. The surgical procedures included access for root instrumentation using either the simplified or the modified papilla preservation flap in order to obtain optimal tissue adaptation and primary closure. After debridement, the regenerative material was applied in the test subjects, and omitted in the controls. At baseline and 1 year following the interventions, clinical attachment levels (CALs), probing pocket depths (PPDs), recession, full-mouth plaque scores and full-mouth bleeding scores (FMBS) were assessed. Results: One year after treatment, the test defects gained 3.3 ± 1.7mm of CAL, while the control defects yielded a significantly lower CAL gain of 2.5 ± 1.5 mm. Pocket reduction was also significantly higher in the test group (3.7 ± 1.8 mm) when compared with the controls (3.2 ± 1.5 mm). A multivariate analysis indicated that the treatment, the clinical centers, baseline PPD and baseline FMBS significantly influenced CAL gains. Odds ratios (ORs) of achieving above-median CAL gains were significantly improved by the test procedure (OR = 2.6, 95% CI 1.2-5.4) and by starting with deeper PPD (OR = 1.7, 1.3-2.2) but were decreased by receiving treatment at the worst-performing clinical center (OR = 0.9, 0.76-0.99). Conclusions: The results of this trial indicated that regenerative periodontal surgery with a GTR/bone replacement material offers an additional benefit in terms of CAL gains, PPD reductions and predictability of outcomes with respect to papilla preservation flaps alone. © Blackwell Munksgaard, 2004.
Persistent Identifierhttp://hdl.handle.net/10722/154517
ISSN
2015 Impact Factor: 3.915
2015 SCImago Journal Rankings: 1.848
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTonetti, MSen_US
dc.contributor.authorCortellini, Pen_US
dc.contributor.authorLang, NPen_US
dc.contributor.authorSuvan, JEen_US
dc.contributor.authorAdriaens, Pen_US
dc.contributor.authorDubravec, Den_US
dc.contributor.authorFonzar, Aen_US
dc.contributor.authorFourmousis, Ien_US
dc.contributor.authorRasperini, Gen_US
dc.contributor.authorRossi, Ren_US
dc.contributor.authorSilvestri, Men_US
dc.contributor.authorTopoll, Hen_US
dc.contributor.authorWallkamm, Ben_US
dc.contributor.authorZybutz, Men_US
dc.date.accessioned2012-08-08T08:25:55Z-
dc.date.available2012-08-08T08:25:55Z-
dc.date.issued2004en_US
dc.identifier.citationJournal Of Clinical Periodontology, 2004, v. 31 n. 9, p. 770-776en_US
dc.identifier.issn0303-6979en_US
dc.identifier.urihttp://hdl.handle.net/10722/154517-
dc.description.abstractAim: This prospective multicenter randomized controlled clinical trial was designed to compare the clinical outcomes of papilla preservation flap surgery with or without the application of a guided tissue regeneration (GTR)/bone replacement material. Materials and Methods: One hundred and twenty-four patients with advanced chronic periodontitis were recruited in 10 centers in seven countries. All patients had at least one intrabony defect of ≥ 3 mm. The surgical procedures included access for root instrumentation using either the simplified or the modified papilla preservation flap in order to obtain optimal tissue adaptation and primary closure. After debridement, the regenerative material was applied in the test subjects, and omitted in the controls. At baseline and 1 year following the interventions, clinical attachment levels (CALs), probing pocket depths (PPDs), recession, full-mouth plaque scores and full-mouth bleeding scores (FMBS) were assessed. Results: One year after treatment, the test defects gained 3.3 ± 1.7mm of CAL, while the control defects yielded a significantly lower CAL gain of 2.5 ± 1.5 mm. Pocket reduction was also significantly higher in the test group (3.7 ± 1.8 mm) when compared with the controls (3.2 ± 1.5 mm). A multivariate analysis indicated that the treatment, the clinical centers, baseline PPD and baseline FMBS significantly influenced CAL gains. Odds ratios (ORs) of achieving above-median CAL gains were significantly improved by the test procedure (OR = 2.6, 95% CI 1.2-5.4) and by starting with deeper PPD (OR = 1.7, 1.3-2.2) but were decreased by receiving treatment at the worst-performing clinical center (OR = 0.9, 0.76-0.99). Conclusions: The results of this trial indicated that regenerative periodontal surgery with a GTR/bone replacement material offers an additional benefit in terms of CAL gains, PPD reductions and predictability of outcomes with respect to papilla preservation flaps alone. © Blackwell Munksgaard, 2004.en_US
dc.languageengen_US
dc.publisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CPEen_US
dc.relation.ispartofJournal of Clinical Periodontologyen_US
dc.subject.meshAlveolar Bone Loss - Surgeryen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBone Substitutesen_US
dc.subject.meshCattleen_US
dc.subject.meshCollagenen_US
dc.subject.meshDental Scalingen_US
dc.subject.meshFemaleen_US
dc.subject.meshGingivaen_US
dc.subject.meshGuided Tissue Regeneration - Methodsen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMembranes, Artificialen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMineralsen_US
dc.subject.meshOral Surgical Procedures - Methodsen_US
dc.subject.meshPeriodontal Indexen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshRegression Analysisen_US
dc.subject.meshSurgical Flapsen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleClinical outcomes following treatment of human intrabony defects with GTR/bone replacement material or access flap alone: A multicenter randomized controlled clinical trialen_US
dc.typeArticleen_US
dc.identifier.emailLang, NP:nplang@hkucc.hku.hken_US
dc.identifier.authorityLang, NP=rp00031en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1600-051X.2004.00562.xen_US
dc.identifier.pmid15312100-
dc.identifier.scopuseid_2-s2.0-4444235986en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-4444235986&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume31en_US
dc.identifier.issue9en_US
dc.identifier.spage770en_US
dc.identifier.epage776en_US
dc.identifier.isiWOS:000223282600011-
dc.publisher.placeDenmarken_US
dc.identifier.scopusauthoridTonetti, MS=35602248900en_US
dc.identifier.scopusauthoridCortellini, P=7004422576en_US
dc.identifier.scopusauthoridLang, NP=7201577367en_US
dc.identifier.scopusauthoridSuvan, JE=19637686000en_US
dc.identifier.scopusauthoridAdriaens, P=7007006026en_US
dc.identifier.scopusauthoridDubravec, D=36963026500en_US
dc.identifier.scopusauthoridFonzar, A=6506961336en_US
dc.identifier.scopusauthoridFourmousis, I=6602718088en_US
dc.identifier.scopusauthoridRasperini, G=6603453130en_US
dc.identifier.scopusauthoridRossi, R=8061093400en_US
dc.identifier.scopusauthoridSilvestri, M=7006617344en_US
dc.identifier.scopusauthoridTopoll, H=7004437263en_US
dc.identifier.scopusauthoridWallkamm, B=6603265034en_US
dc.identifier.scopusauthoridZybutz, M=9633474500en_US

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