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Article: Repeated oral hygiene instructions alone, or in combination with metronidazole dental gel with or without subgingival scaling in adult periodontitis patients: a one-year clinical study.

TitleRepeated oral hygiene instructions alone, or in combination with metronidazole dental gel with or without subgingival scaling in adult periodontitis patients: a one-year clinical study.
Authors
Issue Date2006
Citation
Journal Of The International Academy Of Periodontology, 2006, v. 8 n. 4, p. 125-135 How to Cite?
AbstractThe aims of the present study were to evaluate the clinical efficacy of, and to monitor microbiologically, repeated oral hygiene instructions alone or in combination with metronidazole 25% gel or subgingival scaling with or without metronidazole gel in treatment of new, residual or recurrent periodontal pockets in previously treated adult periodontitis patients. Ten suitable patients were included in this randomized single-blind clinical study with an intra-individual design. Clinical parameters were measured before and at 1, 3, 6, 9 and 12 months after treatment. Subgingival plaque samples were taken at every examination from one selected site in each quadrant. Smears from plaque samples were silver-stained and differential counting was performed under light microscopy at 1000X magnification. Four treatment modalities: (i) oral hygiene instruction (OHI) alone; (ii) OHI and metronidazole dental gel; (iii) OHI and subgingival scaling; (iv) OHI and subgingival scaling plus metronidazole gel, were randomly assigned to one quadrant of each patient. At the 12-month examination, the mean reductions in probing pocket depth were 2.6 mm after OHI alone, 2.8 mm after OHI and metronidazole gel, 3.3 mm after OHI and subgingival scaling and 2.6 mm after oral OHI and subgingival scaling plus metronidazole gel. The mean gains in probing attachment level were 2.2 mm, 1.9 mm, 2.7 mm and 1.6 mm, respectively. Although there were statistically significant differences in treatment responses between some treatment modalities at some time points, these were not considered to be clinically significant. Differential counts showed a shift towards a healthy microflora in response to all treatment modalities. From the 12-month results, it was concluded that the metronidazole 25% gel produced positive effects on the clinical parameters and on the subgingival plaque microbiological composition in new, residual or recurrent pockets in previously treated chronic periodontitis patients. However, the metronidazole gel alone or in combination with scaling does not seem to have any additional clinically significant therapeutic effects over and above those derived from improved oral hygiene resulting from monthly recalls, with or without subgingival scaling.
Persistent Identifierhttp://hdl.handle.net/10722/154480
ISSN
2015 SCImago Journal Rankings: 0.295

 

DC FieldValueLanguage
dc.contributor.authorZee, KYen_US
dc.contributor.authorLee, DHen_US
dc.contributor.authorCorbet, EFen_US
dc.date.accessioned2012-08-08T08:25:33Z-
dc.date.available2012-08-08T08:25:33Z-
dc.date.issued2006en_US
dc.identifier.citationJournal Of The International Academy Of Periodontology, 2006, v. 8 n. 4, p. 125-135en_US
dc.identifier.issn1466-2094en_US
dc.identifier.urihttp://hdl.handle.net/10722/154480-
dc.description.abstractThe aims of the present study were to evaluate the clinical efficacy of, and to monitor microbiologically, repeated oral hygiene instructions alone or in combination with metronidazole 25% gel or subgingival scaling with or without metronidazole gel in treatment of new, residual or recurrent periodontal pockets in previously treated adult periodontitis patients. Ten suitable patients were included in this randomized single-blind clinical study with an intra-individual design. Clinical parameters were measured before and at 1, 3, 6, 9 and 12 months after treatment. Subgingival plaque samples were taken at every examination from one selected site in each quadrant. Smears from plaque samples were silver-stained and differential counting was performed under light microscopy at 1000X magnification. Four treatment modalities: (i) oral hygiene instruction (OHI) alone; (ii) OHI and metronidazole dental gel; (iii) OHI and subgingival scaling; (iv) OHI and subgingival scaling plus metronidazole gel, were randomly assigned to one quadrant of each patient. At the 12-month examination, the mean reductions in probing pocket depth were 2.6 mm after OHI alone, 2.8 mm after OHI and metronidazole gel, 3.3 mm after OHI and subgingival scaling and 2.6 mm after oral OHI and subgingival scaling plus metronidazole gel. The mean gains in probing attachment level were 2.2 mm, 1.9 mm, 2.7 mm and 1.6 mm, respectively. Although there were statistically significant differences in treatment responses between some treatment modalities at some time points, these were not considered to be clinically significant. Differential counts showed a shift towards a healthy microflora in response to all treatment modalities. From the 12-month results, it was concluded that the metronidazole 25% gel produced positive effects on the clinical parameters and on the subgingival plaque microbiological composition in new, residual or recurrent pockets in previously treated chronic periodontitis patients. However, the metronidazole gel alone or in combination with scaling does not seem to have any additional clinically significant therapeutic effects over and above those derived from improved oral hygiene resulting from monthly recalls, with or without subgingival scaling.en_US
dc.languageengen_US
dc.relation.ispartofJournal of the International Academy of Periodontologyen_US
dc.subject.meshAdulten_US
dc.subject.meshAnti-Infective Agents - Therapeutic Useen_US
dc.subject.meshDental Scalingen_US
dc.subject.meshEpidemiologic Methodsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMetronidazole - Therapeutic Useen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOral Hygiene - Educationen_US
dc.subject.meshPeriodontal Pocket - Drug Therapy - Microbiology - Therapyen_US
dc.subject.meshPeriodontitis - Drug Therapy - Microbiology - Therapyen_US
dc.titleRepeated oral hygiene instructions alone, or in combination with metronidazole dental gel with or without subgingival scaling in adult periodontitis patients: a one-year clinical study.en_US
dc.typeArticleen_US
dc.identifier.emailCorbet, EF:efcorbet@hku.hken_US
dc.identifier.authorityCorbet, EF=rp00005en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid17042168-
dc.identifier.scopuseid_2-s2.0-34547884017en_US
dc.identifier.hkuros123857-
dc.identifier.volume8en_US
dc.identifier.issue4en_US
dc.identifier.spage125en_US
dc.identifier.epage135en_US
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridZee, KY=6603722366en_US
dc.identifier.scopusauthoridLee, DH=7406668292en_US
dc.identifier.scopusauthoridCorbet, EF=35609873200en_US

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