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Article: Comparison of the effects of cetylpyridinium chloride with an essential oil mouth rinse on dental plaque and gingivitis - a six-month randomized controlled clinical trial

TitleComparison of the effects of cetylpyridinium chloride with an essential oil mouth rinse on dental plaque and gingivitis - a six-month randomized controlled clinical trial
Authors
Issue Date2007
PublisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CPE
Citation
Journal Of Clinical Periodontology, 2007, v. 34 n. 8, p. 658-667 How to Cite?
AbstractObjective: To compare the effects of an experimental mouth rinse containing 0.07? cetylpyridinium chloride (CPC) (Crest Pro-Health®) with those provided by a commercially available mouth rinse containing essential oils (EOs) (Listerine®) on dental plaque accumulation and prevention of gingivitis in an unsupervised 6-month randomized clinical trial. Material and Methods: This double-blind, 6-month, parallel group, positively controlled study involved 151 subjects balanced and randomly assigned to either positive control (EO) or experimental (CPC) mouth rinse treatment groups. At baseline, subjects received a dental prophylaxis procedure and began unsupervised rinsing twice a day with 20 ml of their assigned mouthwash for 30 s after brushing their teeth for 1 min. Subjects were assessed for gingivitis and gingival bleeding by the Gingival index (GI) of Löe & Silness (1963) and plaque by the Silness & Löe (1964) Plaque index at baseline and after 3 and 6 months of rinsing. At 3 and 6 months, oral soft tissue health was assessed. Microbiological samples were also taken for community profiling by the DNA checkerboard method. Results: Results show that after 3 and 6 months of rinsing, there were no significant differences (p=0.05) between the experimental (CPC) and the positive control mouth rinse treatment groups for overall gingivitis status, gingival bleeding, and plaque accumulation. At 6 months, the covariant (baseline) adjusted mean GI and bleeding sites percentages for the CPC and the EO rinses were 0.52 and 0.53 and 8.7 and 9.3, respectively. Both mouth rinses were well tolerated by the subjects. Microbiological community profiles were similar for the two treatment groups. Statistically, a significant greater reduction in bleeding sites was observed for the CPC rinse versus the EO rinse. Conclusion: The essential findings of this study indicated that there was no statistically significant difference in the anti-plaque and anti-gingivitis benefits between the experimental CPC mouth rinse and the positive control EO mouth rinse over a 6-month period. © 2007 Blackwell Munksgaard.
Persistent Identifierhttp://hdl.handle.net/10722/154474
ISSN
2015 Impact Factor: 3.915
2015 SCImago Journal Rankings: 1.848
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorAlbertKiszely, Aen_US
dc.contributor.authorPjetursson, BEen_US
dc.contributor.authorSalvi, GEen_US
dc.contributor.authorWitt, Jen_US
dc.contributor.authorHamilton, Aen_US
dc.contributor.authorPersson, GRen_US
dc.contributor.authorLang, NPen_US
dc.date.accessioned2012-08-08T08:25:32Z-
dc.date.available2012-08-08T08:25:32Z-
dc.date.issued2007en_US
dc.identifier.citationJournal Of Clinical Periodontology, 2007, v. 34 n. 8, p. 658-667en_US
dc.identifier.issn0303-6979en_US
dc.identifier.urihttp://hdl.handle.net/10722/154474-
dc.description.abstractObjective: To compare the effects of an experimental mouth rinse containing 0.07? cetylpyridinium chloride (CPC) (Crest Pro-Health®) with those provided by a commercially available mouth rinse containing essential oils (EOs) (Listerine®) on dental plaque accumulation and prevention of gingivitis in an unsupervised 6-month randomized clinical trial. Material and Methods: This double-blind, 6-month, parallel group, positively controlled study involved 151 subjects balanced and randomly assigned to either positive control (EO) or experimental (CPC) mouth rinse treatment groups. At baseline, subjects received a dental prophylaxis procedure and began unsupervised rinsing twice a day with 20 ml of their assigned mouthwash for 30 s after brushing their teeth for 1 min. Subjects were assessed for gingivitis and gingival bleeding by the Gingival index (GI) of Löe & Silness (1963) and plaque by the Silness & Löe (1964) Plaque index at baseline and after 3 and 6 months of rinsing. At 3 and 6 months, oral soft tissue health was assessed. Microbiological samples were also taken for community profiling by the DNA checkerboard method. Results: Results show that after 3 and 6 months of rinsing, there were no significant differences (p=0.05) between the experimental (CPC) and the positive control mouth rinse treatment groups for overall gingivitis status, gingival bleeding, and plaque accumulation. At 6 months, the covariant (baseline) adjusted mean GI and bleeding sites percentages for the CPC and the EO rinses were 0.52 and 0.53 and 8.7 and 9.3, respectively. Both mouth rinses were well tolerated by the subjects. Microbiological community profiles were similar for the two treatment groups. Statistically, a significant greater reduction in bleeding sites was observed for the CPC rinse versus the EO rinse. Conclusion: The essential findings of this study indicated that there was no statistically significant difference in the anti-plaque and anti-gingivitis benefits between the experimental CPC mouth rinse and the positive control EO mouth rinse over a 6-month period. © 2007 Blackwell Munksgaard.en_US
dc.languageengen_US
dc.publisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CPEen_US
dc.relation.ispartofJournal of Clinical Periodontologyen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAnti-Infective Agents, Local - Therapeutic Useen_US
dc.subject.meshCetylpyridinium - Therapeutic Useen_US
dc.subject.meshDental Plaque - Drug Therapy - Microbiologyen_US
dc.subject.meshEpidemiologic Methodsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGingivitis - Drug Therapy - Prevention & Controlen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMouthwashes - Therapeutic Useen_US
dc.subject.meshOils, Volatile - Therapeutic Useen_US
dc.titleComparison of the effects of cetylpyridinium chloride with an essential oil mouth rinse on dental plaque and gingivitis - a six-month randomized controlled clinical trialen_US
dc.typeArticleen_US
dc.identifier.emailLang, NP:nplang@hkucc.hku.hken_US
dc.identifier.authorityLang, NP=rp00031en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1600-051X.2007.01103.xen_US
dc.identifier.pmid17635245-
dc.identifier.scopuseid_2-s2.0-34547222417en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34547222417&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume34en_US
dc.identifier.issue8en_US
dc.identifier.spage658en_US
dc.identifier.epage667en_US
dc.identifier.isiWOS:000248451400004-
dc.publisher.placeDenmarken_US
dc.identifier.scopusauthoridAlbertKiszely, A=17344985000en_US
dc.identifier.scopusauthoridPjetursson, BE=6506841442en_US
dc.identifier.scopusauthoridSalvi, GE=35600695300en_US
dc.identifier.scopusauthoridWitt, J=8953251000en_US
dc.identifier.scopusauthoridHamilton, A=36871314200en_US
dc.identifier.scopusauthoridPersson, GR=7101853867en_US
dc.identifier.scopusauthoridLang, NP=7201577367en_US
dc.identifier.citeulike1463139-

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