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Article: Adjunctive local antibiotic therapy in the treatment of peri-implantitis II: Clinical and radiographic outcomes

TitleAdjunctive local antibiotic therapy in the treatment of peri-implantitis II: Clinical and radiographic outcomes
Authors
Issue Date2007
PublisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CLR
Citation
Clinical Oral Implants Research, 2007, v. 18 n. 3, p. 281-285 How to Cite?
AbstractAim: To monitor over 12 months clinical and radiographic changes occurring after adjunctive local delivery of minocycline microspheres for the treatment of peri-implantitis. Material and methods: In 25 partially edentulous subjects, 31 implants diagnosed with peri-implantitis were treated. Three weeks after oral hygiene instruction, mechanical debridement and local antiseptic cleansing using 0.2% chlorhexidine gel, baseline (Day 0) parameters were recorded. Minocycline microspheres (Arestin®) were locally delivered to each implant site with bone loss and a probing pocket depth (PPD) ≥5 mm. Rescue therapy with Arestin® was allowed at Days 180 and 270 at any site exhibiting an increase in PPD≥2 mm from the previous visit. The following clinical parameters were recorded at four sites/implant at Day 0, 10, 30, 60, 90, 180, 270 and 360: PPD, clinical attachment level (CAL), bleeding on probing (BOP) and plaque index (PlI). Results: Six implants in six subjects were either rescued or exited because of persisting active peri-implantitis. Successful implants showed a statistically significant reduction in both PPD and percentage of sites with BOP between baseline and Day 360 (P<0.05). At mesial implant sites, the mean PPD reduction amounted to 1.6 mm (95% CI: 0.9-2.2 mm, P<0.001) and was accompanied by a statistically significant reduction of the BOP value (P<0.001). Binary regression analysis showed that the clinical parameters and smoking history could not discriminate between successfully treated and rescued or exited implants at any observation time point. Conclusion: Non-surgical mechanical treatment of peri-implantitis lesions with adjunctive local delivery of microencapsulated minocycline led to positive effects on clinical parameters up to 12 months. © 2007 Blackwell Munksgaard.
Persistent Identifierhttp://hdl.handle.net/10722/154472
ISSN
2015 Impact Factor: 3.464
2015 SCImago Journal Rankings: 1.427
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSalvi, GEen_US
dc.contributor.authorPersson, GRen_US
dc.contributor.authorHeitzMayfield, LJAen_US
dc.contributor.authorFrei, Men_US
dc.contributor.authorLang, NPen_US
dc.date.accessioned2012-08-08T08:25:31Z-
dc.date.available2012-08-08T08:25:31Z-
dc.date.issued2007en_US
dc.identifier.citationClinical Oral Implants Research, 2007, v. 18 n. 3, p. 281-285en_US
dc.identifier.issn0905-7161en_US
dc.identifier.urihttp://hdl.handle.net/10722/154472-
dc.description.abstractAim: To monitor over 12 months clinical and radiographic changes occurring after adjunctive local delivery of minocycline microspheres for the treatment of peri-implantitis. Material and methods: In 25 partially edentulous subjects, 31 implants diagnosed with peri-implantitis were treated. Three weeks after oral hygiene instruction, mechanical debridement and local antiseptic cleansing using 0.2% chlorhexidine gel, baseline (Day 0) parameters were recorded. Minocycline microspheres (Arestin®) were locally delivered to each implant site with bone loss and a probing pocket depth (PPD) ≥5 mm. Rescue therapy with Arestin® was allowed at Days 180 and 270 at any site exhibiting an increase in PPD≥2 mm from the previous visit. The following clinical parameters were recorded at four sites/implant at Day 0, 10, 30, 60, 90, 180, 270 and 360: PPD, clinical attachment level (CAL), bleeding on probing (BOP) and plaque index (PlI). Results: Six implants in six subjects were either rescued or exited because of persisting active peri-implantitis. Successful implants showed a statistically significant reduction in both PPD and percentage of sites with BOP between baseline and Day 360 (P<0.05). At mesial implant sites, the mean PPD reduction amounted to 1.6 mm (95% CI: 0.9-2.2 mm, P<0.001) and was accompanied by a statistically significant reduction of the BOP value (P<0.001). Binary regression analysis showed that the clinical parameters and smoking history could not discriminate between successfully treated and rescued or exited implants at any observation time point. Conclusion: Non-surgical mechanical treatment of peri-implantitis lesions with adjunctive local delivery of microencapsulated minocycline led to positive effects on clinical parameters up to 12 months. © 2007 Blackwell Munksgaard.en_US
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CLRen_US
dc.relation.ispartofClinical Oral Implants Researchen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAlveolar Bone Loss - Drug Therapy - Etiology - Radiographyen_US
dc.subject.meshAnti-Bacterial Agents - Therapeutic Useen_US
dc.subject.meshDental Implants - Adverse Effectsen_US
dc.subject.meshEpidemiologic Methodsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMandibular Diseases - Drug Therapy - Etiology - Radiographyen_US
dc.subject.meshMaxillary Diseases - Drug Therapy - Etiology - Radiographyen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMinocycline - Therapeutic Useen_US
dc.titleAdjunctive local antibiotic therapy in the treatment of peri-implantitis II: Clinical and radiographic outcomesen_US
dc.typeArticleen_US
dc.identifier.emailLang, NP:nplang@hkucc.hku.hken_US
dc.identifier.authorityLang, NP=rp00031en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1600-0501.2007.01377.xen_US
dc.identifier.pmid17355354-
dc.identifier.scopuseid_2-s2.0-34547181757en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34547181757&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume18en_US
dc.identifier.issue3en_US
dc.identifier.spage281en_US
dc.identifier.epage285en_US
dc.identifier.isiWOS:000247240800003-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridSalvi, GE=35600695300en_US
dc.identifier.scopusauthoridPersson, GR=7101853867en_US
dc.identifier.scopusauthoridHeitzMayfield, LJA=6602309146en_US
dc.identifier.scopusauthoridFrei, M=17345791500en_US
dc.identifier.scopusauthoridLang, NP=7201577367en_US
dc.identifier.citeulike1313243-

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