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Article: Postoperative IMRT in head and neck cancer

TitlePostoperative IMRT in head and neck cancer
Authors
Issue Date2006
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.ro-journal.com
Citation
Radiation Oncology, 2006, v. 1, article no. 40 How to Cite?
AbstractBackground: Aim of this work was to assess loco-regional disease control in head and neck cancer (HNC) patients treated with postoperative intensity modulated radiation therapy (pIMRT). For comparative purposes, risk features of our series have been analysed with respect to histopathologic adverse factors. Results were compared with an own historic conventional radiation (3DCRT) series, and with 3DCRT and pIMRT data from other centres. Between January 2002 and August 2006, 71 patients were consecutively treated with pIMRT for a squamous cell carcinoma (SCC) of the oropharynx (32), oral cavity (22), hypopharynx (7), larynx (6), paranasal sinus (3), and an unknown primary, respectively. Mean and median follow up was 19 months (2-48), and 17.6 months. 83% were treated with IMRT-chemotherapy. Mean prescribed dose was 66.3 Gy (60-70), delivered with doses per fraction of 2-2.3 Gy, respectively. Results: 2-year local, nodal, and distant control rates were 95%, 91%, and 96%, disease free and overall survival 90% and 83%, respectively. The corresponding survival rates for the subgroup of patients with a follow up time >12 months (n = 43) were 98%, 95%, 98%, 93%, and 88%, respectively. Distribution according to histopathologic risk features revealed 15% and 85% patients with intermediate and high risk, respectively. All loco-regional events occurred in the high risk subgroup. Conclusion: Surgery followed by postoperative IMRT in patients with substantial risk for recurrence resulted in high loco-regional tumor control rates compared with large prospective 3DCRT trials. © 2006 Studer et al; licensee BioMed Central Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/154458
ISSN
2015 Impact Factor: 2.466
2015 SCImago Journal Rankings: 1.278
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
Zurich Cancer League
Funding Information:

Financial support: This work was in part supported by the 'Zurich Cancer League'

References

 

DC FieldValueLanguage
dc.contributor.authorStuder, Gen_US
dc.contributor.authorFurrer, Ken_US
dc.contributor.authorDavis, BJen_US
dc.contributor.authorStoeckli, SSen_US
dc.contributor.authorZwahlen, RAen_US
dc.contributor.authorLuetolf, UMen_US
dc.contributor.authorGlanzmann, Cen_US
dc.date.accessioned2012-08-08T08:25:26Z-
dc.date.available2012-08-08T08:25:26Z-
dc.date.issued2006en_US
dc.identifier.citationRadiation Oncology, 2006, v. 1, article no. 40en_US
dc.identifier.issn1748-717Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/154458-
dc.description.abstractBackground: Aim of this work was to assess loco-regional disease control in head and neck cancer (HNC) patients treated with postoperative intensity modulated radiation therapy (pIMRT). For comparative purposes, risk features of our series have been analysed with respect to histopathologic adverse factors. Results were compared with an own historic conventional radiation (3DCRT) series, and with 3DCRT and pIMRT data from other centres. Between January 2002 and August 2006, 71 patients were consecutively treated with pIMRT for a squamous cell carcinoma (SCC) of the oropharynx (32), oral cavity (22), hypopharynx (7), larynx (6), paranasal sinus (3), and an unknown primary, respectively. Mean and median follow up was 19 months (2-48), and 17.6 months. 83% were treated with IMRT-chemotherapy. Mean prescribed dose was 66.3 Gy (60-70), delivered with doses per fraction of 2-2.3 Gy, respectively. Results: 2-year local, nodal, and distant control rates were 95%, 91%, and 96%, disease free and overall survival 90% and 83%, respectively. The corresponding survival rates for the subgroup of patients with a follow up time >12 months (n = 43) were 98%, 95%, 98%, 93%, and 88%, respectively. Distribution according to histopathologic risk features revealed 15% and 85% patients with intermediate and high risk, respectively. All loco-regional events occurred in the high risk subgroup. Conclusion: Surgery followed by postoperative IMRT in patients with substantial risk for recurrence resulted in high loco-regional tumor control rates compared with large prospective 3DCRT trials. © 2006 Studer et al; licensee BioMed Central Ltd.en_US
dc.languageengen_US
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.ro-journal.comen_US
dc.relation.ispartofRadiation Oncologyen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshCarcinoma, Squamous Cell - radiotherapy - surgery-
dc.subject.meshCombined Modality Therapy - methods-
dc.subject.meshDose-Response Relationship, Drug-
dc.subject.meshHead and Neck Neoplasms - radiotherapy - surgery-
dc.subject.meshRadiotherapy, Intensity-Modulated - methods-
dc.titlePostoperative IMRT in head and neck canceren_US
dc.typeArticleen_US
dc.identifier.emailZwahlen, RA:zwahlen@hku.hken_US
dc.identifier.authorityZwahlen, RA=rp00055en_US
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/1748-717X-1-40en_US
dc.identifier.pmid17052346-
dc.identifier.pmcidPMC1626476-
dc.identifier.scopuseid_2-s2.0-34248366580en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34248366580&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume1, article no. 40en_US
dc.identifier.isiWOS:000204479500040-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridStuder, G=16231684900en_US
dc.identifier.scopusauthoridFurrer, K=19733298000en_US
dc.identifier.scopusauthoridDavis, BJ=7403922286en_US
dc.identifier.scopusauthoridStoeckli, SS=7003882748en_US
dc.identifier.scopusauthoridZwahlen, RA=7004217269en_US
dc.identifier.scopusauthoridLuetolf, UM=6602285520en_US
dc.identifier.scopusauthoridGlanzmann, C=7005122985en_US
dc.identifier.citeulike907228-

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