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Article: The association of the composite IL-1 genotype with periodontitis progression and/or treatment outcomes: A systematic review

TitleThe association of the composite IL-1 genotype with periodontitis progression and/or treatment outcomes: A systematic review
Authors
Issue Date2007
PublisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CPE
Citation
Journal Of Clinical Periodontology, 2007, v. 34 n. 4, p. 305-317 How to Cite?
AbstractBackground: Genetically transmitted traits such as cytokine gene polymorphisms may accentuate the host inflammatory response to the bacterial challenge and influence susceptibility to periodonlilis. Objective: To systematically review the evidence of an association between the interleukin-1 (IL-1) composite genotype, i.e. presence of the allele 2 in the gene clusters IL-IA-889 and in IL-IB +3953, and periodontitis progression and/or treatment outcomes. Material and Methods: Based on the focused question, a search was conducted for longitudinal clinical trials comparing progression of periodontitis and/or treatment outcomes in IL-I genotype-positive (carrying allele 2) and IL-I genotype-negative (not carrying allele 2) subjects. A search in the National Library of Medicine computerized bibliographic database MEDLINE and a manual search were performed. Selection of publications, extraction of data and validity assessment were made independently by two reviewers. Results: The search provided 122 titles of which 11 longitudinal publications were included. The heterogeneity of the dato prevented the performance of a meta-analysis. While findings from some publications rejected a possible role of IL-I composite genotype on progression of periodontitis after various therapies, other reported a prognostic value for disease progression of the positive IL-I genotype status. When assessed on a multivariatc risk assessment model, several publications concluded that the assessment of the IL-1 composite genotype in conjunction with other covariates (e.g. smoking and presence of specific bacteria) may provide additional information on disease progression. The small sample size of the available publications, however, requires caution in the interpretation of the results. Conclusion: Based on these findings, (i) there is insufficient evidence to establish if a positive IL-I genotype status contributes to progression of periodontitis and/or treatment outcomes. Therefore, (ii) results obtained with commercially available tests should be interpreted with caution. © 2007 Blackwell Munksgaard.
Persistent Identifierhttp://hdl.handle.net/10722/154450
ISSN
2015 Impact Factor: 3.915
2015 SCImago Journal Rankings: 1.848
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHuynhBa, Gen_US
dc.contributor.authorLang, NPen_US
dc.contributor.authorTonetti, MSen_US
dc.contributor.authorSalvi, GEen_US
dc.date.accessioned2012-08-08T08:25:24Z-
dc.date.available2012-08-08T08:25:24Z-
dc.date.issued2007en_US
dc.identifier.citationJournal Of Clinical Periodontology, 2007, v. 34 n. 4, p. 305-317en_US
dc.identifier.issn0303-6979en_US
dc.identifier.urihttp://hdl.handle.net/10722/154450-
dc.description.abstractBackground: Genetically transmitted traits such as cytokine gene polymorphisms may accentuate the host inflammatory response to the bacterial challenge and influence susceptibility to periodonlilis. Objective: To systematically review the evidence of an association between the interleukin-1 (IL-1) composite genotype, i.e. presence of the allele 2 in the gene clusters IL-IA-889 and in IL-IB +3953, and periodontitis progression and/or treatment outcomes. Material and Methods: Based on the focused question, a search was conducted for longitudinal clinical trials comparing progression of periodontitis and/or treatment outcomes in IL-I genotype-positive (carrying allele 2) and IL-I genotype-negative (not carrying allele 2) subjects. A search in the National Library of Medicine computerized bibliographic database MEDLINE and a manual search were performed. Selection of publications, extraction of data and validity assessment were made independently by two reviewers. Results: The search provided 122 titles of which 11 longitudinal publications were included. The heterogeneity of the dato prevented the performance of a meta-analysis. While findings from some publications rejected a possible role of IL-I composite genotype on progression of periodontitis after various therapies, other reported a prognostic value for disease progression of the positive IL-I genotype status. When assessed on a multivariatc risk assessment model, several publications concluded that the assessment of the IL-1 composite genotype in conjunction with other covariates (e.g. smoking and presence of specific bacteria) may provide additional information on disease progression. The small sample size of the available publications, however, requires caution in the interpretation of the results. Conclusion: Based on these findings, (i) there is insufficient evidence to establish if a positive IL-I genotype status contributes to progression of periodontitis and/or treatment outcomes. Therefore, (ii) results obtained with commercially available tests should be interpreted with caution. © 2007 Blackwell Munksgaard.en_US
dc.languageengen_US
dc.publisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CPEen_US
dc.relation.ispartofJournal of Clinical Periodontologyen_US
dc.subject.meshAllelesen_US
dc.subject.meshDental Scalingen_US
dc.subject.meshDisease Progressionen_US
dc.subject.meshGene Frequencyen_US
dc.subject.meshGenetic Predisposition To Diseaseen_US
dc.subject.meshGuided Tissue Regeneration, Periodontalen_US
dc.subject.meshHumansen_US
dc.subject.meshInterleukin-1 - Geneticsen_US
dc.subject.meshPeriodontal Indexen_US
dc.subject.meshPeriodontitis - Genetics - Therapyen_US
dc.subject.meshPolymorphism, Geneticen_US
dc.subject.meshReproducibility Of Resultsen_US
dc.subject.meshSmokingen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleThe association of the composite IL-1 genotype with periodontitis progression and/or treatment outcomes: A systematic reviewen_US
dc.typeArticleen_US
dc.identifier.emailLang, NP:nplang@hkucc.hku.hken_US
dc.identifier.authorityLang, NP=rp00031en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1600-051X.2007.01055.xen_US
dc.identifier.pmid17378887-
dc.identifier.scopuseid_2-s2.0-33947432485en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33947432485&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume34en_US
dc.identifier.issue4en_US
dc.identifier.spage305en_US
dc.identifier.epage317en_US
dc.identifier.isiWOS:000244978300006-
dc.publisher.placeDenmarken_US
dc.identifier.scopusauthoridHuynhBa, G=25825004200en_US
dc.identifier.scopusauthoridLang, NP=7201577367en_US
dc.identifier.scopusauthoridTonetti, MS=35602248900en_US
dc.identifier.scopusauthoridSalvi, GE=35600695300en_US
dc.identifier.citeulike1173170-

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