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Article: Morphogenesis of the peri-implant mucosa: An experimental study in dogs

TitleMorphogenesis of the peri-implant mucosa: An experimental study in dogs
Authors
Issue Date2007
PublisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CLR
Citation
Clinical Oral Implants Research, 2007, v. 18 n. 1, p. 1-8 How to Cite?
AbstractPurpose: The objective of the present experiment was to study the morphogenesis of the mucosal attachment to implants made of c.p. titanium. Material and methods: All mandibular premolars were extracted in 20 Labrador dogs. After a healing period of 3 months, four implants (ITI® Dental Implant System) were placed in the right and left sides of the mandible. A non-submerged implant installation technique was used and the mucosal tissues were secured to the conical marginal portion of the implants with interrupted sutures. The sutures were removed after 2 weeks and a plaque control program including daily cleaning of the remaining teeth and the implants was initiated. The animals were sacrificed and biopsies were obtained at various intervals to provide healing periods extending from Day 0 (2 h) to 12 weeks. The mandibles were removed and placed in the fixative. The implant sites were dissected using a diamond saw and processed for histological analysis. Results: Large numbers of neutrophils infiltrated and degraded the coagulum that occupied the compartment between the mucosa and the implant during the initial phase of healing. At 2 weeks after surgery, fibroblasts were the dominating cell population in the connective tissue interface but at 4 weeks the density of fibroblasts had decreased. Furthermore, the first signs of epithelial proliferation were observed in specimens representing 1-2 weeks of healing and a mature barrier epithelium occurred after 6-8 weeks of healing. The collagen fibers of the mucosa were organized after 4-6 weeks of healing. Conclusion: It is suggested that the soft-tissue attachment to implants placed using a non-submerged installation procedure is properly established after several weeks following surgery. Copyright © Blackwell Munksgaard 2007.
Persistent Identifierhttp://hdl.handle.net/10722/154437
ISSN
2015 Impact Factor: 3.464
2015 SCImago Journal Rankings: 1.427
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorBerglundh, Ten_US
dc.contributor.authorAbrahamsson, Ien_US
dc.contributor.authorWelander, Men_US
dc.contributor.authorLang, NPen_US
dc.contributor.authorLindhe, Jen_US
dc.date.accessioned2012-08-08T08:25:19Z-
dc.date.available2012-08-08T08:25:19Z-
dc.date.issued2007en_US
dc.identifier.citationClinical Oral Implants Research, 2007, v. 18 n. 1, p. 1-8en_US
dc.identifier.issn0905-7161en_US
dc.identifier.urihttp://hdl.handle.net/10722/154437-
dc.description.abstractPurpose: The objective of the present experiment was to study the morphogenesis of the mucosal attachment to implants made of c.p. titanium. Material and methods: All mandibular premolars were extracted in 20 Labrador dogs. After a healing period of 3 months, four implants (ITI® Dental Implant System) were placed in the right and left sides of the mandible. A non-submerged implant installation technique was used and the mucosal tissues were secured to the conical marginal portion of the implants with interrupted sutures. The sutures were removed after 2 weeks and a plaque control program including daily cleaning of the remaining teeth and the implants was initiated. The animals were sacrificed and biopsies were obtained at various intervals to provide healing periods extending from Day 0 (2 h) to 12 weeks. The mandibles were removed and placed in the fixative. The implant sites were dissected using a diamond saw and processed for histological analysis. Results: Large numbers of neutrophils infiltrated and degraded the coagulum that occupied the compartment between the mucosa and the implant during the initial phase of healing. At 2 weeks after surgery, fibroblasts were the dominating cell population in the connective tissue interface but at 4 weeks the density of fibroblasts had decreased. Furthermore, the first signs of epithelial proliferation were observed in specimens representing 1-2 weeks of healing and a mature barrier epithelium occurred after 6-8 weeks of healing. The collagen fibers of the mucosa were organized after 4-6 weeks of healing. Conclusion: It is suggested that the soft-tissue attachment to implants placed using a non-submerged installation procedure is properly established after several weeks following surgery. Copyright © Blackwell Munksgaard 2007.en_US
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CLRen_US
dc.relation.ispartofClinical Oral Implants Researchen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBlood Coagulation - Physiologyen_US
dc.subject.meshCollagenen_US
dc.subject.meshConnective Tissue - Growth & Development - Pathologyen_US
dc.subject.meshDental Implantsen_US
dc.subject.meshDental Materialsen_US
dc.subject.meshDogsen_US
dc.subject.meshEpithelial Attachment - Growth & Development - Pathologyen_US
dc.subject.meshEpithelium - Growth & Development - Pathologyen_US
dc.subject.meshFibroblasts - Pathology - Physiologyen_US
dc.subject.meshMandible - Surgeryen_US
dc.subject.meshModels, Animalen_US
dc.subject.meshMorphogenesis - Physiologyen_US
dc.subject.meshNeutrophils - Pathology - Physiologyen_US
dc.subject.meshPeriodontium - Growth & Development - Pathologyen_US
dc.subject.meshTitaniumen_US
dc.subject.meshWound Healing - Physiologyen_US
dc.titleMorphogenesis of the peri-implant mucosa: An experimental study in dogsen_US
dc.typeArticleen_US
dc.identifier.emailLang, NP:nplang@hkucc.hku.hken_US
dc.identifier.authorityLang, NP=rp00031en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1600-0501.2006.01380.xen_US
dc.identifier.pmid17224016-
dc.identifier.scopuseid_2-s2.0-33846191511en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33846191511&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume18en_US
dc.identifier.issue1en_US
dc.identifier.spage1en_US
dc.identifier.epage8en_US
dc.identifier.isiWOS:000243442100001-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridBerglundh, T=26643204700en_US
dc.identifier.scopusauthoridAbrahamsson, I=9635463000en_US
dc.identifier.scopusauthoridWelander, M=36973506000en_US
dc.identifier.scopusauthoridLang, NP=7201577367en_US
dc.identifier.scopusauthoridLindhe, J=7101988857en_US

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