File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Hyphal invasion of Candida albicans inhibits the expression of human β-defensins in experimental oral candidiasis

TitleHyphal invasion of Candida albicans inhibits the expression of human β-defensins in experimental oral candidiasis
Authors
Issue Date2006
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/jid/index.html
Citation
Journal Of Investigative Dermatology, 2006, v. 126 n. 9, p. 2049-2056 How to Cite?
AbstractOral epithelium reacts to microbial challenges by eliciting a defensive response that includes the production of antimicrobial peptides. This study investigated the expression of human β-defensins-1, 2, and 3 in reconstituted human oral epithelia during experimental oral infections with six different Candida species, and a wild-type C. albicans isolate and five of its mutants. The expression of defensins was induced after 12 hours infection with the wild-type C. albicans, but this response was not seen for the noninvasive hyphal mutants nor the secreted aspartyl proteinase mutants. Furthermore, defensin expression was not detected after 48 hours in epithelia infected with either C. albicans wild-type isolate or its invasive hyphal and proteinase mutants. Most of the non-albicans Candida were capable of inducing the expression of defensins in epithelia after 24 or 48 hours of infection. These Candida-host interaction patterns suggest that the oral epithelia possess mechanisms for sensing the early invasion of C. albicans through recognition of the presence of hyphae and proteinases of Candida and respond to the insult by producing antimicrobial peptides. This hyphal-invasion-dependent inhibition of defensin expression in oral epithelium that undermines the host surveillance system represents a hitherto undescribed novel pathogenic mechanism of C. albicans. © 2006 The Society for Investigative Dermatology.
Persistent Identifierhttp://hdl.handle.net/10722/154419
ISSN
2015 Impact Factor: 6.915
2015 SCImago Journal Rankings: 2.612
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLu, Qen_US
dc.contributor.authorJayatilake, JAMSen_US
dc.contributor.authorSamaranayake, LPen_US
dc.contributor.authorJin, Len_US
dc.date.accessioned2012-08-08T08:25:13Z-
dc.date.available2012-08-08T08:25:13Z-
dc.date.issued2006en_US
dc.identifier.citationJournal Of Investigative Dermatology, 2006, v. 126 n. 9, p. 2049-2056en_US
dc.identifier.issn0022-202Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/154419-
dc.description.abstractOral epithelium reacts to microbial challenges by eliciting a defensive response that includes the production of antimicrobial peptides. This study investigated the expression of human β-defensins-1, 2, and 3 in reconstituted human oral epithelia during experimental oral infections with six different Candida species, and a wild-type C. albicans isolate and five of its mutants. The expression of defensins was induced after 12 hours infection with the wild-type C. albicans, but this response was not seen for the noninvasive hyphal mutants nor the secreted aspartyl proteinase mutants. Furthermore, defensin expression was not detected after 48 hours in epithelia infected with either C. albicans wild-type isolate or its invasive hyphal and proteinase mutants. Most of the non-albicans Candida were capable of inducing the expression of defensins in epithelia after 24 or 48 hours of infection. These Candida-host interaction patterns suggest that the oral epithelia possess mechanisms for sensing the early invasion of C. albicans through recognition of the presence of hyphae and proteinases of Candida and respond to the insult by producing antimicrobial peptides. This hyphal-invasion-dependent inhibition of defensin expression in oral epithelium that undermines the host surveillance system represents a hitherto undescribed novel pathogenic mechanism of C. albicans. © 2006 The Society for Investigative Dermatology.en_US
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/jid/index.htmlen_US
dc.relation.ispartofJournal of Investigative Dermatologyen_US
dc.subject.meshAspartic Acid Endopeptidases - Geneticsen_US
dc.subject.meshCandida Albicans - Genetics - Physiology - Ultrastructureen_US
dc.subject.meshCandidiasis, Oral - Microbiology - Physiopathologyen_US
dc.subject.meshCells, Cultureden_US
dc.subject.meshFungal Proteins - Geneticsen_US
dc.subject.meshGene Expression - Physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshHyphae - Physiologyen_US
dc.subject.meshKeratinocytes - Cytology - Microbiology - Physiologyen_US
dc.subject.meshKeratins - Geneticsen_US
dc.subject.meshMutationen_US
dc.subject.meshRna, Messenger - Metabolismen_US
dc.subject.meshBeta-Defensins - Genetics - Metabolismen_US
dc.titleHyphal invasion of Candida albicans inhibits the expression of human β-defensins in experimental oral candidiasisen_US
dc.typeArticleen_US
dc.identifier.emailSamaranayake, LP:lakshman@hku.hken_US
dc.identifier.emailJin, L:ljjin@hkucc.hku.hken_US
dc.identifier.authoritySamaranayake, LP=rp00023en_US
dc.identifier.authorityJin, L=rp00028en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1038/sj.jid.5700346en_US
dc.identifier.pmid16741514-
dc.identifier.scopuseid_2-s2.0-33747339180en_US
dc.identifier.hkuros119372-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33747339180&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume126en_US
dc.identifier.issue9en_US
dc.identifier.spage2049en_US
dc.identifier.epage2056en_US
dc.identifier.eissn1523-1747-
dc.identifier.isiWOS:000241359200017-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLu, Q=36128876000en_US
dc.identifier.scopusauthoridJayatilake, JAMS=8441671500en_US
dc.identifier.scopusauthoridSamaranayake, LP=7102761002en_US
dc.identifier.scopusauthoridJin, L=7403328850en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats