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Article: The effect of enamel matrix proteins and deproteinized bovine bone mineral on heterotopic bone formation

TitleThe effect of enamel matrix proteins and deproteinized bovine bone mineral on heterotopic bone formation
Authors
Issue Date2006
PublisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CLR
Citation
Clinical Oral Implants Research, 2006, v. 17 n. 4, p. 434-438 How to Cite?
AbstractAim: To evaluate the osteoinductive potential of deproteinized bovine bone mineral (DBBM) and an enamel matrix derivative (EMD) in the muscle of rats. Material and methods: Sixteen rats were used in this study. The animals were divided in three groups. Group A: a pouch was created in one of the pectoralis profundis muscles of the thorax of the rats and DBBM particles (Bio-Oss®) were placed into the pouch. Healing: 60 days. Group B: a small pouch was created on both pectoralis profundis muscles at each side of the thorax midline. In one side, a mixture of EMD (Emdogain®) mixed with DBBM was placed into one of the pouches, whereas in the contralateral side of the thorax the pouch was implanted with DBBM mixed with the propylene glycol alginate (PGA - carrier for enamel matrix proteins of EMD). Healing: 60 days. Group C: the same procedure as group B, but with a healing period of 120 days. Qualitative histological analysis of the results was performed. Results: At 60 days, the histological appearance of the DBBM particles implanted alone was similar to that of the particles implanted together with EMD or PGA at both 60 and 120 days. The DBBM particles were encapsulated into a connective tissue stroma and an inflammatory infiltrate. At 120 days, the DBBM particles implanted together with EMD or PGA exhibited the presence of resorption lacunae in some cases. Intramuscular bone formation was not encountered in any group. Conclusion: The implantation of DBBM particles alone, combined with EMD or its carrier (PGA) failed to exhibit extraskeletal, bone-inductive properties. Copyright © Blackwell Munksgaard 2006.
Persistent Identifierhttp://hdl.handle.net/10722/154414
ISSN
2015 Impact Factor: 3.464
2015 SCImago Journal Rankings: 1.427
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorDonos, Nen_US
dc.contributor.authorKostopoulos, Len_US
dc.contributor.authorTonetti, Men_US
dc.contributor.authorKarring, Ten_US
dc.contributor.authorLang, NPen_US
dc.date.accessioned2012-08-08T08:25:11Z-
dc.date.available2012-08-08T08:25:11Z-
dc.date.issued2006en_US
dc.identifier.citationClinical Oral Implants Research, 2006, v. 17 n. 4, p. 434-438en_US
dc.identifier.issn0905-7161en_US
dc.identifier.urihttp://hdl.handle.net/10722/154414-
dc.description.abstractAim: To evaluate the osteoinductive potential of deproteinized bovine bone mineral (DBBM) and an enamel matrix derivative (EMD) in the muscle of rats. Material and methods: Sixteen rats were used in this study. The animals were divided in three groups. Group A: a pouch was created in one of the pectoralis profundis muscles of the thorax of the rats and DBBM particles (Bio-Oss®) were placed into the pouch. Healing: 60 days. Group B: a small pouch was created on both pectoralis profundis muscles at each side of the thorax midline. In one side, a mixture of EMD (Emdogain®) mixed with DBBM was placed into one of the pouches, whereas in the contralateral side of the thorax the pouch was implanted with DBBM mixed with the propylene glycol alginate (PGA - carrier for enamel matrix proteins of EMD). Healing: 60 days. Group C: the same procedure as group B, but with a healing period of 120 days. Qualitative histological analysis of the results was performed. Results: At 60 days, the histological appearance of the DBBM particles implanted alone was similar to that of the particles implanted together with EMD or PGA at both 60 and 120 days. The DBBM particles were encapsulated into a connective tissue stroma and an inflammatory infiltrate. At 120 days, the DBBM particles implanted together with EMD or PGA exhibited the presence of resorption lacunae in some cases. Intramuscular bone formation was not encountered in any group. Conclusion: The implantation of DBBM particles alone, combined with EMD or its carrier (PGA) failed to exhibit extraskeletal, bone-inductive properties. Copyright © Blackwell Munksgaard 2006.en_US
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CLRen_US
dc.relation.ispartofClinical Oral Implants Researchen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBone Substitutes - Pharmacologyen_US
dc.subject.meshCattleen_US
dc.subject.meshDental Enamel Proteins - Pharmacologyen_US
dc.subject.meshMinerals - Pharmacologyen_US
dc.subject.meshMuscles - Drug Effectsen_US
dc.subject.meshMuscular Diseases - Etiologyen_US
dc.subject.meshOssification, Heterotopic - Etiologyen_US
dc.subject.meshOsteogenesis - Physiologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.titleThe effect of enamel matrix proteins and deproteinized bovine bone mineral on heterotopic bone formationen_US
dc.typeArticleen_US
dc.identifier.emailLang, NP:nplang@hkucc.hku.hken_US
dc.identifier.authorityLang, NP=rp00031en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1600-0501.2006.01260.xen_US
dc.identifier.pmid16907775-
dc.identifier.scopuseid_2-s2.0-33746350770en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33746350770&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume17en_US
dc.identifier.issue4en_US
dc.identifier.spage434en_US
dc.identifier.epage438en_US
dc.identifier.isiWOS:000239187900012-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridDonos, N=7004314492en_US
dc.identifier.scopusauthoridKostopoulos, L=6603960784en_US
dc.identifier.scopusauthoridTonetti, M=35602248900en_US
dc.identifier.scopusauthoridKarring, T=35560651200en_US
dc.identifier.scopusauthoridLang, NP=7201577367en_US
dc.identifier.citeulike774020-

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