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Article: Evaluation of an in situ formed synthetic hydrogel as a biodegradable membrane for guided bone regeneration

TitleEvaluation of an in situ formed synthetic hydrogel as a biodegradable membrane for guided bone regeneration
Authors
Issue Date2006
PublisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CLR
Citation
Clinical Oral Implants Research, 2006, v. 17 n. 4, p. 426-433 How to Cite?
AbstractThe aim of the present study was to test whether or not the application of an in situ formed synthetic hydrogel made of polyethylene glycol (PEG) used as a biodegradable membrane for guided bone regeneration will result in the same amount of bone regeneration as with the use of an expanded polytetrafluoro- ethylene (ePTFE) membrane. In eight New Zealand White rabbits, four evenly distributed 6 mm diameter defects were drilled into the calvarial bone. Three treatment modalities were evenly distributed among the 32 defects: hydroxyapatite (HA)/tricalciumphosphate (TCP) granules covered at the outer and inner surface with a PEG membrane (test), HA/TCP granules covered at the outer and inner surface with an ePTFE membrane (positive control) and HA/ TCP granules alone without membranes (negative control). After 4 weeks, the animals were sacrificed and the calvarial bones were removed. The area fraction of newly formed bone was determined by histomorphometrical analysis of the vertical sections from the middle of the defect and by micro-computed tomography of the entire defect. Multiple regression analysis (SAS® GLM) was used to model the amount of new bone formation. The quantitative histomorphometric analysis clearly revealed higher values of newly formed bone for the two membrane groups compared with the negative control group. The average area fractions of newly formed bone measured within the former defect amounted to 20.3 ± 9.5% for the PEG membrane, 18.9 ± 9.9% for the ePTFE membrane, and 7.3 ± 5.3% for the sites with no membrane. The micro-computed tomography also showed higher values of new bone formation for the PEG and for the ePTFE groups compared with the negative control group. The GLM revealed a highly significant effect of the treatment on the amount of bone formation (P = 0.0048). The values for the negative control group were significantly lower than the ones found in the PEG membrane group (P = 0.0017), whereas the ePTFE membrane group showed no significant difference from the PEG membrane group. It is concluded that the PEG membrane can be used successfully as a biodegradable barrier membrane in the treatment of non-critical-size defects in the rabbit skull, and leads to similar amounts of bone regeneration as an ePTFE membrane. Copyright © Blackwell Munksgaard 2006.
Persistent Identifierhttp://hdl.handle.net/10722/154413
ISSN
2015 Impact Factor: 3.464
2015 SCImago Journal Rankings: 1.427
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorJung, REen_US
dc.contributor.authorZwahlen, Ren_US
dc.contributor.authorWeber, FEen_US
dc.contributor.authorMolenberg, Aen_US
dc.contributor.authorVan Lenthe, GHen_US
dc.contributor.authorHammerle, CHFen_US
dc.date.accessioned2012-08-08T08:25:11Z-
dc.date.available2012-08-08T08:25:11Z-
dc.date.issued2006en_US
dc.identifier.citationClinical Oral Implants Research, 2006, v. 17 n. 4, p. 426-433en_US
dc.identifier.issn0905-7161en_US
dc.identifier.urihttp://hdl.handle.net/10722/154413-
dc.description.abstractThe aim of the present study was to test whether or not the application of an in situ formed synthetic hydrogel made of polyethylene glycol (PEG) used as a biodegradable membrane for guided bone regeneration will result in the same amount of bone regeneration as with the use of an expanded polytetrafluoro- ethylene (ePTFE) membrane. In eight New Zealand White rabbits, four evenly distributed 6 mm diameter defects were drilled into the calvarial bone. Three treatment modalities were evenly distributed among the 32 defects: hydroxyapatite (HA)/tricalciumphosphate (TCP) granules covered at the outer and inner surface with a PEG membrane (test), HA/TCP granules covered at the outer and inner surface with an ePTFE membrane (positive control) and HA/ TCP granules alone without membranes (negative control). After 4 weeks, the animals were sacrificed and the calvarial bones were removed. The area fraction of newly formed bone was determined by histomorphometrical analysis of the vertical sections from the middle of the defect and by micro-computed tomography of the entire defect. Multiple regression analysis (SAS® GLM) was used to model the amount of new bone formation. The quantitative histomorphometric analysis clearly revealed higher values of newly formed bone for the two membrane groups compared with the negative control group. The average area fractions of newly formed bone measured within the former defect amounted to 20.3 ± 9.5% for the PEG membrane, 18.9 ± 9.9% for the ePTFE membrane, and 7.3 ± 5.3% for the sites with no membrane. The micro-computed tomography also showed higher values of new bone formation for the PEG and for the ePTFE groups compared with the negative control group. The GLM revealed a highly significant effect of the treatment on the amount of bone formation (P = 0.0048). The values for the negative control group were significantly lower than the ones found in the PEG membrane group (P = 0.0017), whereas the ePTFE membrane group showed no significant difference from the PEG membrane group. It is concluded that the PEG membrane can be used successfully as a biodegradable barrier membrane in the treatment of non-critical-size defects in the rabbit skull, and leads to similar amounts of bone regeneration as an ePTFE membrane. Copyright © Blackwell Munksgaard 2006.en_US
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CLRen_US
dc.relation.ispartofClinical Oral Implants Researchen_US
dc.subject.meshAbsorbable Implantsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshGuided Tissue Regeneration - Methodsen_US
dc.subject.meshHydrogelsen_US
dc.subject.meshLinear Modelsen_US
dc.subject.meshMembranes, Artificialen_US
dc.subject.meshOsteogenesisen_US
dc.subject.meshRabbitsen_US
dc.subject.meshSkull - Surgeryen_US
dc.titleEvaluation of an in situ formed synthetic hydrogel as a biodegradable membrane for guided bone regenerationen_US
dc.typeArticleen_US
dc.identifier.emailZwahlen, R:zwahlen@hku.hken_US
dc.identifier.authorityZwahlen, R=rp00055en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1600-0501.2005.01228.xen_US
dc.identifier.pmid16907774-
dc.identifier.scopuseid_2-s2.0-33746339908en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33746339908&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume17en_US
dc.identifier.issue4en_US
dc.identifier.spage426en_US
dc.identifier.epage433en_US
dc.identifier.isiWOS:000239187900011-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridJung, RE=7201892502en_US
dc.identifier.scopusauthoridZwahlen, R=7004217269en_US
dc.identifier.scopusauthoridWeber, FE=7201702808en_US
dc.identifier.scopusauthoridMolenberg, A=35248543300en_US
dc.identifier.scopusauthoridVan Lenthe, GH=6603207667en_US
dc.identifier.scopusauthoridHammerle, CHF=7005331848en_US
dc.identifier.citeulike774021-

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