Article: (B1) Candida and mycotic infections.

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Title(B1) Candida and mycotic infections.
AuthorsCoogan, MM1
Fidel Jr, PL1
Komesu, MC1
Maeda, N1
Samaranayake, LP1
Issue Date2006
PublisherInternational and American Associations for Dental Research. The Journal's web site is located at http://adr.sagepub.com/
CitationAdvances In Dental Research., 2006, v. 19 n. 1, p. 130-138 [How to Cite?]
DOI: http://dx.doi.org/10.1177/154407370601900124
AbstractOral candidiasis (OC) is the most common mucosal manifestation of HIV infection. This workshop examined OC and other mycoses associated with HIV infection. Historically, blood CD4 cell numbers were the primary prognosticator for the development of OC. However, a study that statistically evaluated the predictive role of HIV viral load vs. CD4 cell counts revealed viral load to be a stronger predictor for OC. The role of biofilms and antifungal resistance in recalcitrant OC is unclear at present. In general, micro-organisms including yeasts in biofilms are more resistant to antifungals than their planktonic counterparts. When the remaining organisms are eliminated, the few resistant organisms may not be problematic, because they are present in low numbers. Unusual exotic mycoses in HIV-infected patients are more common in patients from the developing than the developed world. These infections may be recurrent and recalcitrant to therapy, be present in multiple and uncommon sites, increase with the progression of HIV disease, and may play a role similar to that of the more common mycoses. Typing and subtyping of yeasts are probably not critical to the clinical management of candidiasis caused by Candida albicans and non-albicans strains, including C. dubliniensis, because it is responsive to antifungal therapy. C. glabrata is probably the only exception. The presence of oral thrush in infants younger than 6 months of age is associated with an increased post-natal transmission risk of HIV infection. Thus, perinatal retroviral therapy should be combined with the treatment of oral thrush to prevent the post-natal acquisition of HIV.
ISSN1544-0737
2011 SCImago Journal Rankings: 0.127
DOIhttp://dx.doi.org/10.1177/154407370601900124
DC Field
Value
dc.contributor.authorCoogan, MM
dc.contributor.authorFidel Jr, PL
dc.contributor.authorKomesu, MC
dc.contributor.authorMaeda, N
dc.contributor.authorSamaranayake, LP
dc.date.accessioned2012-08-08T08:25:10Z
dc.date.available2012-08-08T08:25:10Z
dc.date.issued2006
dc.description.abstractOral candidiasis (OC) is the most common mucosal manifestation of HIV infection. This workshop examined OC and other mycoses associated with HIV infection. Historically, blood CD4 cell numbers were the primary prognosticator for the development of OC. However, a study that statistically evaluated the predictive role of HIV viral load vs. CD4 cell counts revealed viral load to be a stronger predictor for OC. The role of biofilms and antifungal resistance in recalcitrant OC is unclear at present. In general, micro-organisms including yeasts in biofilms are more resistant to antifungals than their planktonic counterparts. When the remaining organisms are eliminated, the few resistant organisms may not be problematic, because they are present in low numbers. Unusual exotic mycoses in HIV-infected patients are more common in patients from the developing than the developed world. These infections may be recurrent and recalcitrant to therapy, be present in multiple and uncommon sites, increase with the progression of HIV disease, and may play a role similar to that of the more common mycoses. Typing and subtyping of yeasts are probably not critical to the clinical management of candidiasis caused by Candida albicans and non-albicans strains, including C. dubliniensis, because it is responsive to antifungal therapy. C. glabrata is probably the only exception. The presence of oral thrush in infants younger than 6 months of age is associated with an increased post-natal transmission risk of HIV infection. Thus, perinatal retroviral therapy should be combined with the treatment of oral thrush to prevent the post-natal acquisition of HIV.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationAdvances In Dental Research., 2006, v. 19 n. 1, p. 130-138 [How to Cite?]
DOI: http://dx.doi.org/10.1177/154407370601900124
dc.identifier.doihttp://dx.doi.org/10.1177/154407370601900124
dc.identifier.epage138
dc.identifier.hkuros115938
dc.identifier.issn1544-0737
2011 SCImago Journal Rankings: 0.127
dc.identifier.issue1
dc.identifier.pmid16672563
dc.identifier.scopuseid_2-s2.0-33745942709
dc.identifier.spage130
dc.identifier.urihttp://hdl.handle.net/10722/154410
dc.identifier.volume19
dc.languageeng
dc.publisherInternational and American Associations for Dental Research. The Journal's web site is located at http://adr.sagepub.com/
dc.publisher.placeUnited States
dc.relation.ispartofAdvances in dental research.
dc.subject.meshAids-Related Opportunistic Infections - Epidemiology - Microbiology
dc.subject.meshAntifungal Agents - Therapeutic Use
dc.subject.meshBiofilms
dc.subject.meshCd4 Lymphocyte Count
dc.subject.meshCandida - Classification - Genetics
dc.subject.meshCandidiasis, Oral - Microbiology
dc.subject.meshDeveloping Countries
dc.subject.meshDrug Resistance, Fungal
dc.subject.meshHiv Infections - Transmission
dc.subject.meshHumans
dc.subject.meshInfant
dc.subject.meshMycological Typing Techniques
dc.subject.meshMycoses - Complications - Drug Therapy - Epidemiology
dc.subject.meshPrevalence
dc.subject.meshPrognosis
dc.subject.meshViral Load
dc.title(B1) Candida and mycotic infections.
dc.typeArticle
Author Affiliations
  1. University of Witwatersrand