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Article: (B1) Candida and mycotic infections.
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Title(B1) Candida and mycotic infections.
 
AuthorsCoogan, MM1
Fidel Jr, PL1
Komesu, MC1
Maeda, N1
Samaranayake, LP1
 
Issue Date2006
 
PublisherInternational and American Associations for Dental Research. The Journal's web site is located at http://adr.sagepub.com/
 
CitationAdvances In Dental Research., 2006, v. 19 n. 1, p. 130-138 [How to Cite?]
DOI: http://dx.doi.org/10.1177/154407370601900124
 
AbstractOral candidiasis (OC) is the most common mucosal manifestation of HIV infection. This workshop examined OC and other mycoses associated with HIV infection. Historically, blood CD4 cell numbers were the primary prognosticator for the development of OC. However, a study that statistically evaluated the predictive role of HIV viral load vs. CD4 cell counts revealed viral load to be a stronger predictor for OC. The role of biofilms and antifungal resistance in recalcitrant OC is unclear at present. In general, micro-organisms including yeasts in biofilms are more resistant to antifungals than their planktonic counterparts. When the remaining organisms are eliminated, the few resistant organisms may not be problematic, because they are present in low numbers. Unusual exotic mycoses in HIV-infected patients are more common in patients from the developing than the developed world. These infections may be recurrent and recalcitrant to therapy, be present in multiple and uncommon sites, increase with the progression of HIV disease, and may play a role similar to that of the more common mycoses. Typing and subtyping of yeasts are probably not critical to the clinical management of candidiasis caused by Candida albicans and non-albicans strains, including C. dubliniensis, because it is responsive to antifungal therapy. C. glabrata is probably the only exception. The presence of oral thrush in infants younger than 6 months of age is associated with an increased post-natal transmission risk of HIV infection. Thus, perinatal retroviral therapy should be combined with the treatment of oral thrush to prevent the post-natal acquisition of HIV.
 
ISSN1544-0737
2013 SCImago Journal Rankings: 0.745
 
DOIhttp://dx.doi.org/10.1177/154407370601900124
 
DC FieldValue
dc.contributor.authorCoogan, MM
 
dc.contributor.authorFidel Jr, PL
 
dc.contributor.authorKomesu, MC
 
dc.contributor.authorMaeda, N
 
dc.contributor.authorSamaranayake, LP
 
dc.date.accessioned2012-08-08T08:25:10Z
 
dc.date.available2012-08-08T08:25:10Z
 
dc.date.issued2006
 
dc.description.abstractOral candidiasis (OC) is the most common mucosal manifestation of HIV infection. This workshop examined OC and other mycoses associated with HIV infection. Historically, blood CD4 cell numbers were the primary prognosticator for the development of OC. However, a study that statistically evaluated the predictive role of HIV viral load vs. CD4 cell counts revealed viral load to be a stronger predictor for OC. The role of biofilms and antifungal resistance in recalcitrant OC is unclear at present. In general, micro-organisms including yeasts in biofilms are more resistant to antifungals than their planktonic counterparts. When the remaining organisms are eliminated, the few resistant organisms may not be problematic, because they are present in low numbers. Unusual exotic mycoses in HIV-infected patients are more common in patients from the developing than the developed world. These infections may be recurrent and recalcitrant to therapy, be present in multiple and uncommon sites, increase with the progression of HIV disease, and may play a role similar to that of the more common mycoses. Typing and subtyping of yeasts are probably not critical to the clinical management of candidiasis caused by Candida albicans and non-albicans strains, including C. dubliniensis, because it is responsive to antifungal therapy. C. glabrata is probably the only exception. The presence of oral thrush in infants younger than 6 months of age is associated with an increased post-natal transmission risk of HIV infection. Thus, perinatal retroviral therapy should be combined with the treatment of oral thrush to prevent the post-natal acquisition of HIV.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationAdvances In Dental Research., 2006, v. 19 n. 1, p. 130-138 [How to Cite?]
DOI: http://dx.doi.org/10.1177/154407370601900124
 
dc.identifier.doihttp://dx.doi.org/10.1177/154407370601900124
 
dc.identifier.epage138
 
dc.identifier.hkuros115938
 
dc.identifier.issn1544-0737
2013 SCImago Journal Rankings: 0.745
 
dc.identifier.issue1
 
dc.identifier.pmid16672563
 
dc.identifier.scopuseid_2-s2.0-33745942709
 
dc.identifier.spage130
 
dc.identifier.urihttp://hdl.handle.net/10722/154410
 
dc.identifier.volume19
 
dc.languageeng
 
dc.publisherInternational and American Associations for Dental Research. The Journal's web site is located at http://adr.sagepub.com/
 
dc.publisher.placeUnited States
 
dc.relation.ispartofAdvances in dental research.
 
dc.subject.meshAids-Related Opportunistic Infections - Epidemiology - Microbiology
 
dc.subject.meshAntifungal Agents - Therapeutic Use
 
dc.subject.meshBiofilms
 
dc.subject.meshCd4 Lymphocyte Count
 
dc.subject.meshCandida - Classification - Genetics
 
dc.subject.meshCandidiasis, Oral - Microbiology
 
dc.subject.meshDeveloping Countries
 
dc.subject.meshDrug Resistance, Fungal
 
dc.subject.meshHiv Infections - Transmission
 
dc.subject.meshHumans
 
dc.subject.meshInfant
 
dc.subject.meshMycological Typing Techniques
 
dc.subject.meshMycoses - Complications - Drug Therapy - Epidemiology
 
dc.subject.meshPrevalence
 
dc.subject.meshPrognosis
 
dc.subject.meshViral Load
 
dc.title(B1) Candida and mycotic infections.
 
dc.typeArticle
 
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<item><contributor.author>Coogan, MM</contributor.author>
<contributor.author>Fidel Jr, PL</contributor.author>
<contributor.author>Komesu, MC</contributor.author>
<contributor.author>Maeda, N</contributor.author>
<contributor.author>Samaranayake, LP</contributor.author>
<date.accessioned>2012-08-08T08:25:10Z</date.accessioned>
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<identifier.citation>Advances In Dental Research., 2006, v. 19 n. 1, p. 130-138</identifier.citation>
<identifier.issn>1544-0737</identifier.issn>
<identifier.uri>http://hdl.handle.net/10722/154410</identifier.uri>
<description.abstract>Oral candidiasis (OC) is the most common mucosal manifestation of HIV infection. This workshop examined OC and other mycoses associated with HIV infection. Historically, blood CD4 cell numbers were the primary prognosticator for the development of OC. However, a study that statistically evaluated the predictive role of HIV viral load vs. CD4 cell counts revealed viral load to be a stronger predictor for OC. The role of biofilms and antifungal resistance in recalcitrant OC is unclear at present. In general, micro-organisms including yeasts in biofilms are more resistant to antifungals than their planktonic counterparts. When the remaining organisms are eliminated, the few resistant organisms may not be problematic, because they are present in low numbers. Unusual exotic mycoses in HIV-infected patients are more common in patients from the developing than the developed world. These infections may be recurrent and recalcitrant to therapy, be present in multiple and uncommon sites, increase with the progression of HIV disease, and may play a role similar to that of the more common mycoses. Typing and subtyping of yeasts are probably not critical to the clinical management of candidiasis caused by Candida albicans and non-albicans strains, including C. dubliniensis, because it is responsive to antifungal therapy. C. glabrata is probably the only exception. The presence of oral thrush in infants younger than 6 months of age is associated with an increased post-natal transmission risk of HIV infection. Thus, perinatal retroviral therapy should be combined with the treatment of oral thrush to prevent the post-natal acquisition of HIV.</description.abstract>
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<publisher>International and American Associations for Dental Research. The Journal&apos;s web site is located at http://adr.sagepub.com/</publisher>
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<subject.mesh>Aids-Related Opportunistic Infections - Epidemiology - Microbiology</subject.mesh>
<subject.mesh>Antifungal Agents - Therapeutic Use</subject.mesh>
<subject.mesh>Biofilms</subject.mesh>
<subject.mesh>Cd4 Lymphocyte Count</subject.mesh>
<subject.mesh>Candida - Classification - Genetics</subject.mesh>
<subject.mesh>Candidiasis, Oral - Microbiology</subject.mesh>
<subject.mesh>Developing Countries</subject.mesh>
<subject.mesh>Drug Resistance, Fungal</subject.mesh>
<subject.mesh>Hiv Infections - Transmission</subject.mesh>
<subject.mesh>Humans</subject.mesh>
<subject.mesh>Infant</subject.mesh>
<subject.mesh>Mycological Typing Techniques</subject.mesh>
<subject.mesh>Mycoses - Complications - Drug Therapy - Epidemiology</subject.mesh>
<subject.mesh>Prevalence</subject.mesh>
<subject.mesh>Prognosis</subject.mesh>
<subject.mesh>Viral Load</subject.mesh>
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Author Affiliations
  1. University of Witwatersrand