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Article: Effect of mechanical and antiseptic therapy on peri-implant mucositis: An experimental study in monkeys

TitleEffect of mechanical and antiseptic therapy on peri-implant mucositis: An experimental study in monkeys
Authors
Issue Date2006
PublisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CLR
Citation
Clinical Oral Implants Research, 2006, v. 17 n. 3, p. 294-304 How to Cite?
AbstractObjectives: This experiment was performed to evaluate clinically and histologically the effect of mechanical therapy with or without antiseptic therapy on peri-implant mucositis lesions in nine cynomolgus monkeys. Material and methods: Two ITI titanium implants were inserted into each side of the mandibles. After 90 days of plaque control and soft tissue healing, a baseline clinical examination was completed. Peri-implant lesions were induced by placing silk ligatures and allowing plaque to accumulate for 6 weeks. The clinical examination was then repeated, and the monkeys were randomly assigned to three treatment groups: group A, mechanical cleansing only; group B, mechanical cleansing and local irrigation with 0.12% chlorhexidine (CHX) and application of 0.2% CHX gel; and group C, control, no treatment. The implants in treatment groups A and B were treated and maintained according to the assigned treatment for two additional months. At the end of the maintenance period, a final clinical examination was performed and the animals were sacrificed for biopsies. Results: The mean probing depths (PD) values at mucositis were: 3.5, 3.7, and 3.4 mm, and clinical attachment level (CAL)=3.8, 4.1, and 3.9 mm for treatment groups A, B and C, respectively. The corresponding values after treatment were: PD=1.7, 2.1, and 2.5 mm, and CAL=2.6, 2.6, and 3.1 mm. ANOVA of mean changes (Δ) in PD and CAL after treatment showed no statistical difference between the treatment groups. Comparison of the mean changes in PD and CAL after treatment yielded statistical differences between the control and treatment groups P<0.01. According to the t-test, no statistical difference was found between treatment groups A and B for the PD reduction but there was a significant difference for the CAL change, P<0.03. Group A had significantly more recession and less CAL gain than group B. Non-parametric tests yielded no significant differences in modified plaque index (mPlI) and gingival index (GI) after treatment between both treatment groups. Frequencies and percent distributions of the mPlI and GI scores changed considerably for both treatment groups when compared with the changes in the control group after treatment. With regard to the histological evaluation, no statistical differences existed between the treatments for any linear measurement. The proportion of inflammation found in the mucosal tissues of the control implants was greater than the one found for both treatment groups, P<0.01. More importantly, both treatment groups showed a similar low proportion of inflammation after 2 months of treatment. Conclusions: Within the limitations of this experiment, and considering the supportive plaque control rendered, it can be concluded that for pockets of 3-4 mm: (1) mechanical therapy alone or combined with CHX results in the clinical resolution of peri-implant mucositis lesions, (2) histologically, both treatments result in minimal inflammation compatible with health, and (3) the mechanical effect alone is sufficient to achieve clinical and histologic resolution of mucositis lesions. Copyright © Blackwell Munksgaard 2006.
Persistent Identifierhttp://hdl.handle.net/10722/154404
ISSN
2015 Impact Factor: 3.464
2015 SCImago Journal Rankings: 1.427
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTrejo, PMen_US
dc.contributor.authorBonaventura, Gen_US
dc.contributor.authorWeng, Den_US
dc.contributor.authorCaffesse, RGen_US
dc.contributor.authorBragger, Uen_US
dc.contributor.authorLang, NPen_US
dc.date.accessioned2012-08-08T08:25:07Z-
dc.date.available2012-08-08T08:25:07Z-
dc.date.issued2006en_US
dc.identifier.citationClinical Oral Implants Research, 2006, v. 17 n. 3, p. 294-304en_US
dc.identifier.issn0905-7161en_US
dc.identifier.urihttp://hdl.handle.net/10722/154404-
dc.description.abstractObjectives: This experiment was performed to evaluate clinically and histologically the effect of mechanical therapy with or without antiseptic therapy on peri-implant mucositis lesions in nine cynomolgus monkeys. Material and methods: Two ITI titanium implants were inserted into each side of the mandibles. After 90 days of plaque control and soft tissue healing, a baseline clinical examination was completed. Peri-implant lesions were induced by placing silk ligatures and allowing plaque to accumulate for 6 weeks. The clinical examination was then repeated, and the monkeys were randomly assigned to three treatment groups: group A, mechanical cleansing only; group B, mechanical cleansing and local irrigation with 0.12% chlorhexidine (CHX) and application of 0.2% CHX gel; and group C, control, no treatment. The implants in treatment groups A and B were treated and maintained according to the assigned treatment for two additional months. At the end of the maintenance period, a final clinical examination was performed and the animals were sacrificed for biopsies. Results: The mean probing depths (PD) values at mucositis were: 3.5, 3.7, and 3.4 mm, and clinical attachment level (CAL)=3.8, 4.1, and 3.9 mm for treatment groups A, B and C, respectively. The corresponding values after treatment were: PD=1.7, 2.1, and 2.5 mm, and CAL=2.6, 2.6, and 3.1 mm. ANOVA of mean changes (Δ) in PD and CAL after treatment showed no statistical difference between the treatment groups. Comparison of the mean changes in PD and CAL after treatment yielded statistical differences between the control and treatment groups P<0.01. According to the t-test, no statistical difference was found between treatment groups A and B for the PD reduction but there was a significant difference for the CAL change, P<0.03. Group A had significantly more recession and less CAL gain than group B. Non-parametric tests yielded no significant differences in modified plaque index (mPlI) and gingival index (GI) after treatment between both treatment groups. Frequencies and percent distributions of the mPlI and GI scores changed considerably for both treatment groups when compared with the changes in the control group after treatment. With regard to the histological evaluation, no statistical differences existed between the treatments for any linear measurement. The proportion of inflammation found in the mucosal tissues of the control implants was greater than the one found for both treatment groups, P<0.01. More importantly, both treatment groups showed a similar low proportion of inflammation after 2 months of treatment. Conclusions: Within the limitations of this experiment, and considering the supportive plaque control rendered, it can be concluded that for pockets of 3-4 mm: (1) mechanical therapy alone or combined with CHX results in the clinical resolution of peri-implant mucositis lesions, (2) histologically, both treatments result in minimal inflammation compatible with health, and (3) the mechanical effect alone is sufficient to achieve clinical and histologic resolution of mucositis lesions. Copyright © Blackwell Munksgaard 2006.en_US
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CLRen_US
dc.relation.ispartofClinical Oral Implants Researchen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnti-Infective Agents, Local - Administration & Dosage - Therapeutic Useen_US
dc.subject.meshChlorhexidine - Administration & Dosage - Therapeutic Useen_US
dc.subject.meshDental Implants - Adverse Effectsen_US
dc.subject.meshDental Materials - Chemistryen_US
dc.subject.meshDental Plaque - Complicationsen_US
dc.subject.meshDental Plaque Indexen_US
dc.subject.meshDental Scalingen_US
dc.subject.meshGelsen_US
dc.subject.meshGingival Recession - Pathology - Prevention & Controlen_US
dc.subject.meshGingivitis - Pathology - Prevention & Controlen_US
dc.subject.meshMacaca Fascicularisen_US
dc.subject.meshMandible - Surgeryen_US
dc.subject.meshPeriodontal Attachment Loss - Pathology - Prevention & Controlen_US
dc.subject.meshPeriodontal Indexen_US
dc.subject.meshPeriodontal Pocket - Pathology - Prevention & Controlen_US
dc.subject.meshPeriodontitis - Pathology - Prevention & Controlen_US
dc.subject.meshRandom Allocationen_US
dc.subject.meshTherapeutic Irrigationen_US
dc.subject.meshTitanium - Chemistryen_US
dc.titleEffect of mechanical and antiseptic therapy on peri-implant mucositis: An experimental study in monkeysen_US
dc.typeArticleen_US
dc.identifier.emailLang, NP:nplang@hkucc.hku.hken_US
dc.identifier.authorityLang, NP=rp00031en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1600-0501.2005.01226.xen_US
dc.identifier.pmid16672025-
dc.identifier.scopuseid_2-s2.0-33646521917en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33646521917&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume17en_US
dc.identifier.issue3en_US
dc.identifier.spage294en_US
dc.identifier.epage304en_US
dc.identifier.isiWOS:000237259500009-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridTrejo, PM=6603490065en_US
dc.identifier.scopusauthoridBonaventura, G=6603784630en_US
dc.identifier.scopusauthoridWeng, D=13408388200en_US
dc.identifier.scopusauthoridCaffesse, RG=7005708068en_US
dc.identifier.scopusauthoridBragger, U=7005538598en_US
dc.identifier.scopusauthoridLang, NP=7201577367en_US
dc.identifier.citeulike613213-

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