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Article: Statin-induced osteogenesis uses in orthodontics: a scientific review.

TitleStatin-induced osteogenesis uses in orthodontics: a scientific review.
Authors
Issue Date2006
PublisherQuintessence Publishing Co, Inc.
Citation
World Journal Of Orthodontics., 2006, v. 7 n. 1, p. 35-40 How to Cite?
AbstractThis article summarizes the current research behind the use of statin to induce bone formation and relates that to potential uses in the field of orthodontics. It triggered BMP-2 expression in in vitro studies. In an in vivo study, the amount of new bone formed by statin mixed with a collagen carrier was quantitatively assessed and results showed that 308% more new bone was formed in defects grafted with statin than those grafted with the carrier alone. Immunolocalization studies on the early healing of the defects grafted with statin showed VEGF, BMP-2, Cbfa 1 expression, and new bone formation occurred 1 day earlier than those grafted with the carrier alone. Since statin is a commonly prescribed drug, it has great potential to be used routinely in bone grafting in the craniofacial region.
Persistent Identifierhttp://hdl.handle.net/10722/154398
ISSN
2013 SCImago Journal Rankings: 0.296

 

DC FieldValueLanguage
dc.contributor.authorWong, RWen_US
dc.contributor.authorRabie, ABen_US
dc.date.accessioned2012-08-08T08:25:05Z-
dc.date.available2012-08-08T08:25:05Z-
dc.date.issued2006en_US
dc.identifier.citationWorld Journal Of Orthodontics., 2006, v. 7 n. 1, p. 35-40en_US
dc.identifier.issn1530-5678en_US
dc.identifier.urihttp://hdl.handle.net/10722/154398-
dc.description.abstractThis article summarizes the current research behind the use of statin to induce bone formation and relates that to potential uses in the field of orthodontics. It triggered BMP-2 expression in in vitro studies. In an in vivo study, the amount of new bone formed by statin mixed with a collagen carrier was quantitatively assessed and results showed that 308% more new bone was formed in defects grafted with statin than those grafted with the carrier alone. Immunolocalization studies on the early healing of the defects grafted with statin showed VEGF, BMP-2, Cbfa 1 expression, and new bone formation occurred 1 day earlier than those grafted with the carrier alone. Since statin is a commonly prescribed drug, it has great potential to be used routinely in bone grafting in the craniofacial region.en_US
dc.languageengen_US
dc.publisherQuintessence Publishing Co, Inc.-
dc.relation.ispartofWorld journal of orthodontics.en_US
dc.subject.meshAnimalsen_US
dc.subject.meshBone Morphogenetic Protein 2en_US
dc.subject.meshBone Morphogenetic Proteins - Biosynthesis - Geneticsen_US
dc.subject.meshBone Transplantation - Physiologyen_US
dc.subject.meshDrug Carriersen_US
dc.subject.meshGene Expression Regulation, Developmental - Drug Effectsen_US
dc.subject.meshHumansen_US
dc.subject.meshHydroxymethylglutaryl-Coa Reductase Inhibitors - Pharmacologyen_US
dc.subject.meshOrthodontics - Methodsen_US
dc.subject.meshOsteogenesis - Drug Effectsen_US
dc.subject.meshPromoter Regions, Genetic - Drug Effectsen_US
dc.subject.meshSimvastatin - Pharmacologyen_US
dc.subject.meshTransforming Growth Factor Beta - Biosynthesis - Geneticsen_US
dc.titleStatin-induced osteogenesis uses in orthodontics: a scientific review.en_US
dc.typeArticleen_US
dc.identifier.emailWong, RW:fyoung@hkucc.hku.hken_US
dc.identifier.emailRabie, AB:rabie@hku.hken_US
dc.identifier.authorityWong, RW=rp00038en_US
dc.identifier.authorityRabie, AB=rp00029en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid16548304-
dc.identifier.scopuseid_2-s2.0-33645944965en_US
dc.identifier.hkuros115946-
dc.identifier.volume7en_US
dc.identifier.issue1en_US
dc.identifier.spage35en_US
dc.identifier.epage40en_US
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridWong, RW=7402127170en_US
dc.identifier.scopusauthoridRabie, AB=7007172734en_US

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