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Article: Microbial colonization patterns predict the outcomes of surgical treatment of intrabony defects

TitleMicrobial colonization patterns predict the outcomes of surgical treatment of intrabony defects
Authors
Issue Date2006
PublisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CPE
Citation
Journal Of Clinical Periodontology, 2006, v. 33 n. 1, p. 62-68 How to Cite?
AbstractAim: To explore the impact of bacterial load and microbial colonization patterns on the clinical outcomes of periodontal surgery at deep intrabony defects. Materials and Methods: One hundred and twenty-two patients with advanced chronic periodontitis and at least one intrabony defect of >3 mm were recruited in 10 centres. Before recruitment, the infection control phase of periodontal therapy was completed. After surgical access and debridement, the regenerative material was applied in the test subjects, and omitted in the controls. At baseline and 1 year following the interventions, clinical attachment levels (CAL), pocket probing depths (PPD), recession (REC), full-mouth plaque scores and full-mouth bleeding scores were assessed. Microbial colonization of the defect-associated pocket was assessed using a DNA-DNA checkerboard analysis. Results: Total bacterial load and counts of red complex bacteria were negatively associated with CAL gains 1 year following treatment. The probability of achieving above median CAL gains (>3 mm) was significantly decreased by higher total bacterial counts, higher red complex and T. forsythensis counts immediately before surgery. Conclusions: Presence of high bacterial load and specific periodontal pathogen complexes in deep periodontal pockets associated with intrabony defects had a significant negative impact on the 1 year outcome of surgical/regenerative treatment. © 2006 Blackwell Munksgaard.
Persistent Identifierhttp://hdl.handle.net/10722/154393
ISSN
2015 Impact Factor: 3.915
2015 SCImago Journal Rankings: 1.848
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHeitzMayfield, Len_US
dc.contributor.authorTonetti, MSen_US
dc.contributor.authorCortellini, Pen_US
dc.contributor.authorLang, NPen_US
dc.date.accessioned2012-08-08T08:25:04Z-
dc.date.available2012-08-08T08:25:04Z-
dc.date.issued2006en_US
dc.identifier.citationJournal Of Clinical Periodontology, 2006, v. 33 n. 1, p. 62-68en_US
dc.identifier.issn0303-6979en_US
dc.identifier.urihttp://hdl.handle.net/10722/154393-
dc.description.abstractAim: To explore the impact of bacterial load and microbial colonization patterns on the clinical outcomes of periodontal surgery at deep intrabony defects. Materials and Methods: One hundred and twenty-two patients with advanced chronic periodontitis and at least one intrabony defect of >3 mm were recruited in 10 centres. Before recruitment, the infection control phase of periodontal therapy was completed. After surgical access and debridement, the regenerative material was applied in the test subjects, and omitted in the controls. At baseline and 1 year following the interventions, clinical attachment levels (CAL), pocket probing depths (PPD), recession (REC), full-mouth plaque scores and full-mouth bleeding scores were assessed. Microbial colonization of the defect-associated pocket was assessed using a DNA-DNA checkerboard analysis. Results: Total bacterial load and counts of red complex bacteria were negatively associated with CAL gains 1 year following treatment. The probability of achieving above median CAL gains (>3 mm) was significantly decreased by higher total bacterial counts, higher red complex and T. forsythensis counts immediately before surgery. Conclusions: Presence of high bacterial load and specific periodontal pathogen complexes in deep periodontal pockets associated with intrabony defects had a significant negative impact on the 1 year outcome of surgical/regenerative treatment. © 2006 Blackwell Munksgaard.en_US
dc.languageengen_US
dc.publisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CPEen_US
dc.relation.ispartofJournal of Clinical Periodontologyen_US
dc.subject.meshAlveolar Bone Loss - Surgeryen_US
dc.subject.meshBacteria, Anaerobic - Growth & Developmenten_US
dc.subject.meshColony Count, Microbialen_US
dc.subject.meshDna, Bacterial - Analysisen_US
dc.subject.meshFemaleen_US
dc.subject.meshGuided Tissue Regeneration, Periodontal - Methodsen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPeriodontal Pocket - Microbiologyen_US
dc.subject.meshPeriodontitis - Surgeryen_US
dc.subject.meshPrognosisen_US
dc.subject.meshRegression Analysisen_US
dc.subject.meshStatistics, Nonparametricen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleMicrobial colonization patterns predict the outcomes of surgical treatment of intrabony defectsen_US
dc.typeArticleen_US
dc.identifier.emailLang, NP:nplang@hkucc.hku.hken_US
dc.identifier.authorityLang, NP=rp00031en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1600-051X.2005.00872.xen_US
dc.identifier.pmid16367858-
dc.identifier.scopuseid_2-s2.0-33645072466en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33645072466&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume33en_US
dc.identifier.issue1en_US
dc.identifier.spage62en_US
dc.identifier.epage68en_US
dc.identifier.isiWOS:000233817700010-
dc.publisher.placeDenmarken_US
dc.identifier.scopusauthoridHeitzMayfield, L=6602309146en_US
dc.identifier.scopusauthoridTonetti, MS=35602248900en_US
dc.identifier.scopusauthoridCortellini, P=7004422576en_US
dc.identifier.scopusauthoridLang, NP=7201577367en_US
dc.identifier.citeulike434332-

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