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Article: Histologic and ultrastructural study on statin graft in rabbit skulls

TitleHistologic and ultrastructural study on statin graft in rabbit skulls
Authors
Issue Date2005
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/joms
Citation
Journal Of Oral And Maxillofacial Surgery, 2005, v. 63 n. 10, p. 1515-1521 How to Cite?
AbstractPurpose: To study the early healing pattern of statin-induced osteogenesis, we examined the early histologic and ultrastructural pictures of bone defect healing with and without statin. Materials and Methods: Twenty-eight bone defects were created in the parietal bone of 14 New Zealand White rabbits. In the Statin Group of 7 rabbits, the defects were grafted with collagen matrix carriers mixed with statin solution. In the Collagen Matrix Group of 7 rabbits, the defects were grafted with collagen matrix carriers mixed with water for injection. The Statin Group and the Collagen Matrix Group were killed on day 1, 2, 3, 4, 5, 6, or 14 after surgery. Bone defects with surrounding tissues were prepared for histologic assessment. Bone defects of day 14 were also prepared for ultrastructural assessment. Results: New bone was formed on day 5 in the defects grafted with statin. No cartilage intermediate stage was detected. This occurred 1 day earlier than for those grafted with the carrier alone. The bone defects of day 14 showed that an abundance of bone was formed in the Statin Group and osteocytes were identified ultrastructurally. Conclusions: This study supported statin-induced and accelerated bone formation locally. © 2005 American Association of Oral and Maxillofacial Surgeons.
Persistent Identifierhttp://hdl.handle.net/10722/154359
ISSN
2015 Impact Factor: 1.631
2015 SCImago Journal Rankings: 0.824
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, RWKen_US
dc.contributor.authorRabie, ABMen_US
dc.date.accessioned2012-08-08T08:24:52Z-
dc.date.available2012-08-08T08:24:52Z-
dc.date.issued2005en_US
dc.identifier.citationJournal Of Oral And Maxillofacial Surgery, 2005, v. 63 n. 10, p. 1515-1521en_US
dc.identifier.issn0278-2391en_US
dc.identifier.urihttp://hdl.handle.net/10722/154359-
dc.description.abstractPurpose: To study the early healing pattern of statin-induced osteogenesis, we examined the early histologic and ultrastructural pictures of bone defect healing with and without statin. Materials and Methods: Twenty-eight bone defects were created in the parietal bone of 14 New Zealand White rabbits. In the Statin Group of 7 rabbits, the defects were grafted with collagen matrix carriers mixed with statin solution. In the Collagen Matrix Group of 7 rabbits, the defects were grafted with collagen matrix carriers mixed with water for injection. The Statin Group and the Collagen Matrix Group were killed on day 1, 2, 3, 4, 5, 6, or 14 after surgery. Bone defects with surrounding tissues were prepared for histologic assessment. Bone defects of day 14 were also prepared for ultrastructural assessment. Results: New bone was formed on day 5 in the defects grafted with statin. No cartilage intermediate stage was detected. This occurred 1 day earlier than for those grafted with the carrier alone. The bone defects of day 14 showed that an abundance of bone was formed in the Statin Group and osteocytes were identified ultrastructurally. Conclusions: This study supported statin-induced and accelerated bone formation locally. © 2005 American Association of Oral and Maxillofacial Surgeons.en_US
dc.languageengen_US
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/jomsen_US
dc.relation.ispartofJournal of Oral and Maxillofacial Surgeryen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBone Regeneration - Drug Effectsen_US
dc.subject.meshBone And Bones - Ultrastructureen_US
dc.subject.meshCollagen - Pharmacologyen_US
dc.subject.meshDrug Carriersen_US
dc.subject.meshMicroscopy, Electron, Scanningen_US
dc.subject.meshRabbitsen_US
dc.subject.meshSimvastatin - Pharmacologyen_US
dc.subject.meshSkull - Surgeryen_US
dc.titleHistologic and ultrastructural study on statin graft in rabbit skullsen_US
dc.typeArticleen_US
dc.identifier.emailWong, RWK:fyoung@hkucc.hku.hken_US
dc.identifier.emailRabie, ABM:rabie@hku.hken_US
dc.identifier.authorityWong, RWK=rp00038en_US
dc.identifier.authorityRabie, ABM=rp00029en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.joms.2005.06.009en_US
dc.identifier.pmid16182921-
dc.identifier.scopuseid_2-s2.0-25144447797en_US
dc.identifier.hkuros108286-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-25144447797&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume63en_US
dc.identifier.issue10en_US
dc.identifier.spage1515en_US
dc.identifier.epage1521en_US
dc.identifier.isiWOS:000232289900017-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridWong, RWK=7402127170en_US
dc.identifier.scopusauthoridRabie, ABM=7007172734en_US

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