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Article: The effect of demineralized intramembranous bone matrix and basic fibroblast growth factor on the healing of allogeneic intramembranous bone grafts in the rabbit

TitleThe effect of demineralized intramembranous bone matrix and basic fibroblast growth factor on the healing of allogeneic intramembranous bone grafts in the rabbit
Authors
KeywordsAllogeneic bone
Autogenous bone
bFGF
Bone formation
DBM IM
Issue Date2002
PublisherAmerican Society of Animal Science. The Journal's web site is located at http://jas.fass.org
Citation
Journal Of Animal Science, 2002, v. 80 n. 1, p. 831-841 How to Cite?
AbstractThe aim here was to explore a new graft material that excludes the need to harvest autogenous bone from patients. Forty-two critical-size (10 x 15 mm) defects were created in rabbit mandibles bilaterally. Five groups of six defects each were grafted with autogenous endochondral (EC) bone, autogenous intramembranous (IM) bone, fresh-frozen allogeneic IM bone only, fresh-frozen allogeneic IM bone and demineralized bone matrix powder prepared from intramembranous bone (DBM IM) only, and fresh-frozen allogeneic IM bone and basic fibroblast growth factor (bFGF) mixed with DBM IM powder. The remaining defects were used as controls. Three weeks after surgery, the defects were retrieved for histological analysis. The amount of new bone formation was quantified by image analysis. No bone formed across the defect in the controls; 224% more new bone formed in defects grafted with composite allogeneic IM bone/DBM IM than in those grafted with allogeneic IM bone alone (p < 0.001); 550% more new bone was formed in defects grafted with composite allogeneic IM bone/DBM IM/bFGF than in those grafted with allogeneic IM bone alone (p < 0.001). The amount of new bone in the group receiving composite allogeneic IM bone/bFGF/DBM IM was more than that in autogenous EC bone group, and very close to that in autogenous IM group. The results show that a composite of fresh-frozen allogeneic IM bone and bFGF in DBM IM powder is a good graft material that warrants further clinical investigation. © 2002 Elsevier Science Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/154353
ISSN
2015 Impact Factor: 2.014
2015 SCImago Journal Rankings: 1.377
References

 

DC FieldValueLanguage
dc.contributor.authorLu, Men_HK
dc.contributor.authorRabie, ABMen_HK
dc.date.accessioned2012-08-08T08:24:50Z-
dc.date.available2012-08-08T08:24:50Z-
dc.date.issued2002en_HK
dc.identifier.citationJournal Of Animal Science, 2002, v. 80 n. 1, p. 831-841en_HK
dc.identifier.issn0021-8812en_HK
dc.identifier.urihttp://hdl.handle.net/10722/154353-
dc.description.abstractThe aim here was to explore a new graft material that excludes the need to harvest autogenous bone from patients. Forty-two critical-size (10 x 15 mm) defects were created in rabbit mandibles bilaterally. Five groups of six defects each were grafted with autogenous endochondral (EC) bone, autogenous intramembranous (IM) bone, fresh-frozen allogeneic IM bone only, fresh-frozen allogeneic IM bone and demineralized bone matrix powder prepared from intramembranous bone (DBM IM) only, and fresh-frozen allogeneic IM bone and basic fibroblast growth factor (bFGF) mixed with DBM IM powder. The remaining defects were used as controls. Three weeks after surgery, the defects were retrieved for histological analysis. The amount of new bone formation was quantified by image analysis. No bone formed across the defect in the controls; 224% more new bone formed in defects grafted with composite allogeneic IM bone/DBM IM than in those grafted with allogeneic IM bone alone (p < 0.001); 550% more new bone was formed in defects grafted with composite allogeneic IM bone/DBM IM/bFGF than in those grafted with allogeneic IM bone alone (p < 0.001). The amount of new bone in the group receiving composite allogeneic IM bone/bFGF/DBM IM was more than that in autogenous EC bone group, and very close to that in autogenous IM group. The results show that a composite of fresh-frozen allogeneic IM bone and bFGF in DBM IM powder is a good graft material that warrants further clinical investigation. © 2002 Elsevier Science Ltd. All rights reserved.en_HK
dc.languageengen_US
dc.publisherAmerican Society of Animal Science. The Journal's web site is located at http://jas.fass.orgen_HK
dc.relation.ispartofJournal of Animal Scienceen_HK
dc.subjectAllogeneic boneen_HK
dc.subjectAutogenous boneen_HK
dc.subjectbFGFen_HK
dc.subjectBone formationen_HK
dc.subjectDBM IMen_HK
dc.titleThe effect of demineralized intramembranous bone matrix and basic fibroblast growth factor on the healing of allogeneic intramembranous bone grafts in the rabbiten_HK
dc.typeArticleen_HK
dc.identifier.emailRabie, ABM: rabie@hku.hken_HK
dc.identifier.authorityRabie, ABM=rp00029en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-23744433395en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-23744433395&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume80en_HK
dc.identifier.issue1en_HK
dc.identifier.spage831en_HK
dc.identifier.epage841en_HK
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLu, M=7402821078en_HK
dc.identifier.scopusauthoridRabie, ABM=7007172734en_HK

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